"Tubulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A microtubule subunit protein found in large quantities in mammalian brain. It has also been isolated from SPERM FLAGELLUM; CILIA; and other sources. Structurally, the protein is a dimer with a molecular weight of approximately 120,000 and a sedimentation coefficient of 5.8S. It binds to COLCHICINE; VINCRISTINE; and VINBLASTINE.
| Descriptor ID |
D014404
|
| MeSH Number(s) |
D05.750.078.734.800 D12.776.220.600.800 D12.776.631.920
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Tubulin".
Below are MeSH descriptors whose meaning is more specific than "Tubulin".
This graph shows the total number of publications written about "Tubulin" by people in this website by year, and whether "Tubulin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1995 | 0 | 1 | 1 |
| 1997 | 1 | 0 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 3 | 2 | 5 |
| 2002 | 1 | 2 | 3 |
| 2003 | 3 | 6 | 9 |
| 2004 | 1 | 1 | 2 |
| 2005 | 1 | 4 | 5 |
| 2006 | 0 | 3 | 3 |
| 2007 | 1 | 1 | 2 |
| 2008 | 1 | 5 | 6 |
| 2009 | 2 | 5 | 7 |
| 2010 | 1 | 4 | 5 |
| 2011 | 2 | 3 | 5 |
| 2012 | 0 | 2 | 2 |
| 2013 | 1 | 2 | 3 |
| 2014 | 1 | 1 | 2 |
| 2015 | 1 | 4 | 5 |
| 2016 | 1 | 5 | 6 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 2 | 2 |
| 2020 | 0 | 3 | 3 |
| 2021 | 4 | 1 | 5 |
| 2022 | 1 | 1 | 2 |
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click here.
Below are the most recent publications written about "Tubulin" by people in Profiles.
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Bi-allelic CAMSAP1 variants cause a clinically recognizable neuronal migration disorder. Am J Hum Genet. 2022 11 03; 109(11):2068-2079.
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Cryo-ET of Toxoplasma parasites gives subnanometer insight into tubulin-based structures. Proc Natl Acad Sci U S A. 2022 02 08; 119(6).
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Exome sequencing of child-parent trios with bladder exstrophy: Findings in 26 children. Am J Med Genet A. 2021 10; 185(10):3028-3041.
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Phase 1 study of safety, pharmacokinetics, and pharmacodynamics of tivantinib in combination with bevacizumab in adult patients with advanced solid tumors. Cancer Chemother Pharmacol. 2021 10; 88(4):643-654.
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Molecular determinants for a-tubulin methylation by SETD2. J Biol Chem. 2021 07; 297(1):100898.
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Sperm-borne miR-202 targets SEPT7 and regulates first cleavage of bovine embryos via cytoskeletal remodeling. Development. 2021 03 05; 148(5).
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Pathogenic role of delta 2 tubulin in bortezomib-induced peripheral neuropathy. Proc Natl Acad Sci U S A. 2021 01 26; 118(4).
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Synthesis, biological evaluation, and molecular docking analysis of phenstatin based indole linked chalcones as anticancer agents and tubulin polymerization inhibitors. Bioorg Chem. 2020 12; 105:104447.
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Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia. J Nat Prod. 2020 04 24; 83(4):937-954.
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Endosomal Wnt signaling proteins control microtubule nucleation in dendrites. PLoS Biol. 2020 03; 18(3):e3000647.