"Synucleins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of homologous proteins of low MOLECULAR WEIGHT that are predominately expressed in the BRAIN and that have been implicated in a variety of human diseases. They were originally isolated from CHOLINERGIC FIBERS of TORPEDO.
| Descriptor ID |
D051843
|
| MeSH Number(s) |
D12.776.631.860
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Synucleins".
Below are MeSH descriptors whose meaning is more specific than "Synucleins".
This graph shows the total number of publications written about "Synucleins" by people in this website by year, and whether "Synucleins" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 3 | 3 |
| 2005 | 0 | 4 | 4 |
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Below are the most recent publications written about "Synucleins" by people in Profiles.
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APOE e4 increases risk for dementia in pure synucleinopathies. JAMA Neurol. 2013 Feb; 70(2):223-8.
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Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: additional evidence of different genetic pathways. Mod Pathol. 2005 Jun; 18(6):752-61.
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Whole-mount analysis reveals normal numbers of dopaminergic neurons following misexpression of alpha-Synuclein in Drosophila. Genesis. 2005 Apr; 41(4):154-9.
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Gene dosage and pathogenesis of Parkinson's disease. Trends Mol Med. 2005 Mar; 11(3):91-6.
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Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations. Proc Natl Acad Sci U S A. 2005 Feb 08; 102(6):2162-7.
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Abeta deposition is associated with enhanced cortical alpha-synuclein lesions in Lewy body diseases. Neurobiol Aging. 2005 Aug-Sep; 26(8):1183-92.
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Overexpression of synuclein-gamma in pancreatic adenocarcinoma. Cancer. 2004 Jul 01; 101(1):58-65.
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S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function. Science. 2004 May 28; 304(5675):1328-31.
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Caught in the act: alpha-synuclein is the culprit in Parkinson's disease. Neuron. 2003 Oct 30; 40(3):453-6.
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From fruit fly to bedside: translating lessons from Drosophila models of neurodegenerative disease. Curr Opin Neurol. 2003 Aug; 16(4):443-9.