Disks Large Homolog 4 Protein
"Disks Large Homolog 4 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A neuronal protein consisting of three PDZ DOMAINS, an SH3 DOMAIN, and a C-terminal guanylate kinase-like region (see MAGUK PROTEINS). It localizes to the POST-SYNAPTIC DENSITY and associates with the cytoplasmic tail of NMDA RECEPTORS and SHAKER POTASSIUM CHANNELS, playing a critical role in NMDA receptor-mediated SYNAPTIC PLASTICITY.
| Descriptor ID |
D000076122
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| MeSH Number(s) |
D08.811.913.696.650.450.750 D12.644.360.265 D12.776.476.265 D12.776.543.219 D12.776.631.224
|
| Concept/Terms |
Disks Large Homolog 4 Protein- Disks Large Homolog 4 Protein
- Postsynaptic Density Protein 95
- Discs Large Homolog 4 Protein
- SAP-90 Protein
- SAP 90 Protein
- PSD95 Protein
- PSD-95 Protein
- PSD 95 Protein
- Synapse-Associated Protein 90
- Synapse Associated Protein 90
- SAP90 Protein
|
Below are MeSH descriptors whose meaning is more general than "Disks Large Homolog 4 Protein".
Below are MeSH descriptors whose meaning is more specific than "Disks Large Homolog 4 Protein".
This graph shows the total number of publications written about "Disks Large Homolog 4 Protein" by people in this website by year, and whether "Disks Large Homolog 4 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 2 | 0 | 2 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Disks Large Homolog 4 Protein" by people in Profiles.
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Post-ischemic ubiquitination at the postsynaptic density reversibly influences the activity of ischemia-relevant kinases. Commun Biol. 2024 03 13; 7(1):321.
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Alterations in brain synaptic proteins and mRNAs in mood disorders: a systematic review and meta-analysis of postmortem brain studies. Mol Psychiatry. 2022 03; 27(3):1362-1372.
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HDAC6 inhibition reverses long-term doxorubicin-induced cognitive dysfunction by restoring microglia homeostasis and synaptic integrity. Theranostics. 2022; 12(2):603-619.
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Tau induces PSD95-neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration. Nat Neurosci. 2020 09; 23(9):1079-1089.
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Interaction Between CRIPT and PSD-95 Is Required for Proper Dendritic Arborization in Hippocampal Neurons. Mol Neurobiol. 2020 May; 57(5):2479-2493.
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Profile of cortical N-methyl-D-aspartate receptor subunit expression associates with inherent motor impulsivity in rats. Biochem Pharmacol. 2019 10; 168:204-213.
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Pharmacological inhibition of HDAC6 reverses cognitive impairment and tau pathology as a result of cisplatin treatment. Acta Neuropathol Commun. 2018 10 01; 6(1):103.
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Crucial role of calbindin-D28k in the pathogenesis of Alzheimer's disease mouse model. Cell Death Differ. 2014 Oct; 21(10):1575-87.
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Rapid hippocampal network adaptation to recurring synchronous activity--a role for calcineurin. Eur J Neurosci. 2013 Oct; 38(8):3115-27.
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The adhesion-GPCR BAI1 regulates synaptogenesis by controlling the recruitment of the Par3/Tiam1 polarity complex to synaptic sites. J Neurosci. 2013 Apr 17; 33(16):6964-78.