"Syk Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An SH2 domain-containing non-receptor tyrosine kinase that regulates signal transduction downstream of a variety of receptors including B-CELL ANTIGEN RECEPTORS. It functions in both INNATE IMMUNITY and ADAPTIVE IMMUNITY and also mediates signaling in CELL ADHESION; OSTEOGENESIS; PLATELET ACTIVATION; and vascular development.
| Descriptor ID |
D000072377
|
| MeSH Number(s) |
D08.811.913.696.620.682.725.650 D12.644.360.900 D12.776.476.913
|
| Concept/Terms |
Syk Kinase- Syk Kinase
- Kinase, Syk
- SYK Tyrosine Kinase
- Kinase, SYK Tyrosine
- Tyrosine Kinase, SYK
- Spleen Tyrosine Kinase
- Kinase, Spleen Tyrosine
- Tyrosine Kinase, Spleen
|
Below are MeSH descriptors whose meaning is more general than "Syk Kinase".
Below are MeSH descriptors whose meaning is more specific than "Syk Kinase".
This graph shows the total number of publications written about "Syk Kinase" by people in this website by year, and whether "Syk Kinase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 0 | 5 | 5 |
| 2017 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Syk Kinase" by people in Profiles.
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A phase I study of TAK-659 and paclitaxel in patients with taxane-refractory advanced solid tumors. ESMO Open. 2024 Jun; 9(6):103486.
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SYK is activated by mutated MYD88 and drives pro-survival signaling in MYD88 driven B-cell lymphomas. Blood Cancer J. 2020 01 31; 10(1):12.
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Spleen Tyrosine Kinase-Mediated Autophagy Is Required for Epithelial-Mesenchymal Plasticity and Metastasis in Breast Cancer. Cancer Res. 2019 Apr 15; 79(8):1831-1843.
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Efficacy and safety of the dual SYK/JAK inhibitor cerdulatinib in patients with relapsed or refractory B-cell malignancies: Results of a phase I study. Am J Hematol. 2019 04; 94(4):E90-E93.
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Linking inflammation and cancer: the unexpected SYK world. Neuro Oncol. 2018 04 09; 20(5):582-583.
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Aberrant SYK Kinase Signaling Is Essential for Tumorigenesis Induced by TSC2 Inactivation. Cancer Res. 2017 03 15; 77(6):1492-1502.
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The Dual Syk/JAK Inhibitor Cerdulatinib Antagonizes B-cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia. Clin Cancer Res. 2017 May 01; 23(9):2313-2324.
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Pre-BCR signaling in precursor B-cell acute lymphoblastic leukemia regulates PI3K/AKT, FOXO1 and MYC, and can be targeted by SYK inhibition. Leukemia. 2016 06; 30(6):1246-54.
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Spleen Tyrosine Kinase (Syk) Mediates IL-1? Induction by Primary Human Monocytes during Antibody-enhanced Dengue Virus Infection. J Biol Chem. 2015 Jul 10; 290(28):17306-20.
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Stromal CYR61 Confers Resistance to Mitoxantrone via Spleen Tyrosine Kinase Activation in Human Acute Myeloid Leukaemia. Br J Haematol. 2015 Sep; 170(5):704-18.