"Cyclin-Dependent Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic activity. Cyclin-dependent kinases are regulated by phosphorylation and dephosphorylation events.
| Descriptor ID |
D018844
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.646.500 D12.644.360.250 D12.776.167.200 D12.776.476.250
|
| Concept/Terms |
Cyclin-Dependent Kinases- Cyclin-Dependent Kinases
- Cyclin Dependent Kinases
- Cyclin-Dependent Protein Kinases
- Cyclin Dependent Protein Kinases
- cdk Proteins
|
Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinases".
Below are MeSH descriptors whose meaning is more specific than "Cyclin-Dependent Kinases".
This graph shows the total number of publications written about "Cyclin-Dependent Kinases" by people in this website by year, and whether "Cyclin-Dependent Kinases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 3 | 0 | 3 |
| 1998 | 2 | 3 | 5 |
| 1999 | 0 | 4 | 4 |
| 2000 | 0 | 4 | 4 |
| 2001 | 2 | 2 | 4 |
| 2002 | 1 | 3 | 4 |
| 2003 | 3 | 2 | 5 |
| 2004 | 1 | 2 | 3 |
| 2005 | 2 | 1 | 3 |
| 2007 | 2 | 1 | 3 |
| 2008 | 1 | 1 | 2 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2016 | 3 | 2 | 5 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2020 | 2 | 1 | 3 |
| 2023 | 1 | 1 | 2 |
| 2024 | 0 | 1 | 1 |
| 2025 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Cyclin-Dependent Kinases" by people in Profiles.
-
Preclinical efficacy of CDK7 inhibitor-based combinations against myeloproliferative neoplasms transformed to AML. Blood. 2025 02 06; 145(6):612-624.
-
Cdk8/CDK19 promotes mitochondrial fission through Drp1 phosphorylation and can phenotypically suppress pink1 deficiency in Drosophila. Nat Commun. 2024 Apr 18; 15(1):3326.
-
CDK regulators-Cell cycle progression or apoptosis-Scenarios in normal cells and cancerous cells. Adv Protein Chem Struct Biol. 2023; 135:125-177.
-
Genome-wide association study of early ischaemic stroke risk in Brazilian individuals with sickle cell disease implicates ADAMTS2 and CDK18 and uncovers novel loci. Br J Haematol. 2023 04; 201(2):343-352.
-
De Novo Variants in CDK19 Are Associated with a Syndrome Involving Intellectual Disability and Epileptic Encephalopathy. Am J Hum Genet. 2020 05 07; 106(5):717-725.
-
A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells. Nat Commun. 2020 02 06; 11(1):740.
-
Epigenetic Targeting of TERT-Associated Gene Expression Signature in Human Neuroblastoma with TERT Overexpression. Cancer Res. 2020 03 01; 80(5):1024-1035.
-
Roles of CDKs in RNA polymerase II transcription of the HIV-1 genome. Transcription. 2019 04; 10(2):111-117.
-
Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers. Nat Genet. 2017 Dec; 49(12):1693-1704.
-
MYC Mediates mRNA Cap Methylation of Canonical Wnt/?-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase. Mol Cancer Res. 2017 02; 15(2):213-224.