"Separase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Separase is a caspase-like cysteine protease, which plays a central role in triggering ANAPHASE by cleaving the SCC1/RAD21 subunit of the cohesin complex. Cohesin holds the sister CHROMATIDS together during METAPHASE and its cleavage results in chromosome segregation.
| Descriptor ID |
D064247
|
| MeSH Number(s) |
D08.811.277.656.262.500.792 D08.811.277.656.300.200.792 D12.776.167.552
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Separase".
Below are MeSH descriptors whose meaning is more specific than "Separase".
This graph shows the total number of publications written about "Separase" by people in this website by year, and whether "Separase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2008 | 0 | 3 | 3 |
| 2009 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 2 | 0 | 2 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Separase" by people in Profiles.
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Functional analysis of a novel de novo variant in PPP5C associated with microcephaly, seizures, and developmental delay. Mol Genet Metab. 2022 05; 136(1):65-73.
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Stability and pharmacokinetics of separase inhibitor-Sepin-1 in Sprague-Dawley rats. Biochem Pharmacol. 2020 04; 174:113808.
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Toxicity study of separase inhibitor-Sepin-1 in Sprague-Dawley rats. Pathol Res Pract. 2020 Jan; 216(1):152730.
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Biology and insights into the role of cohesin protease separase in human malignancies. Biol Rev Camb Philos Soc. 2017 Nov; 92(4):2070-2083.
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Synthesis and activity of benzimidazole-1,3-dioxide inhibitors of separase. Bioorg Med Chem Lett. 2016 09 15; 26(18):4446-4450.
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Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme. J Neurooncol. 2014 Aug; 119(1):27-35.
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Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy. J Biomol Screen. 2014 Jul; 19(6):878-89.
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MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ERa)-positive mammary adenocarcinomas. Oncogene. 2014 Nov 27; 33(48):5511-5522.
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Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice. PLoS One. 2011; 6(7):e22167.
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Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers. Clin Cancer Res. 2009 Apr 15; 15(8):2703-10.