"Cathepsin K" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cysteine protease that is highly expressed in OSTEOCLASTS and plays an essential role in BONE RESORPTION as a potent EXTRACELLULAR MATRIX-degrading enzyme.
| Descriptor ID |
D056657
|
| MeSH Number(s) |
D08.811.277.656.224.405 D08.811.277.656.262.500.156 D08.811.277.656.300.200.156
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cathepsin K".
Below are MeSH descriptors whose meaning is more specific than "Cathepsin K".
This graph shows the total number of publications written about "Cathepsin K" by people in this website by year, and whether "Cathepsin K" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cathepsin K" by people in Profiles.
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Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Immunohistochemistry Can Be a Useful Ancillary Tool to Identify Perivascular Epithelioid Cell Tumor. Mod Pathol. 2024 Mar; 37(3):100426.
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Myelofibrosis osteoclasts are clonal and functionally impaired. Blood. 2019 05 23; 133(21):2320-2324.
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Artemisinin inhibits breast cancer-induced osteolysis by inhibiting osteoclast formation and breast cancer cell proliferation. J Cell Physiol. 2019 08; 234(8):12663-12675.
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Intravital microscopy of osteolytic progression and therapy response of cancer lesions in the bone. Sci Transl Med. 2018 08 01; 10(452).
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A broad survey of cathepsin K immunoreactivity in human neoplasms. Am J Clin Pathol. 2013 Feb; 139(2):151-9.
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Cathepsin K-sensitive poly(ethylene glycol) hydrogels for degradation in response to bone resorption. J Biomed Mater Res A. 2011 Jul; 98(1):53-62.
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Future directions of bone-targeted therapy for metastatic breast cancer. Nat Rev Clin Oncol. 2010 Nov; 7(11):641-51.
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Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progression. Clin Cancer Res. 2008 Sep 01; 14(17):5357-67.
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Transgenic mice that express Cre recombinase in osteoclasts. Genesis. 2004 Jul; 39(3):178-85.
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Inhibition of the cysteine proteinases cathepsins K and L by the serpin headpin (SERPINB13): a kinetic analysis. Arch Biochem Biophys. 2003 Jan 15; 409(2):367-74.