"Calpain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.
| Descriptor ID |
D002154
|
| MeSH Number(s) |
D08.811.277.656.262.500.120 D08.811.277.656.300.200.120
|
| Concept/Terms |
Calpain- Calpain
- Calcium-Activated Protease
- Calcium Activated Protease
- Protease, Calcium-Activated
- Calcium-Dependent Neutral Proteinase
- Calcium Dependent Neutral Proteinase
- Neutral Proteinase, Calcium-Dependent
- Proteinase, Calcium-Dependent Neutral
- Calcium-Dependent Neutral Protease
- Calcium Dependent Neutral Protease
- Neutral Protease, Calcium-Dependent
- Protease, Calcium-Dependent Neutral
- Desminase
- Ca2+-Activated Protease
- Ca2+ Activated Protease
- Protease, Ca2+-Activated
- Calcium-Activated Neutral Proteinase
- Calcium Activated Neutral Proteinase
- Neutral Proteinase, Calcium-Activated
- Proteinase, Calcium-Activated Neutral
- Calcium-Activated Neutral Protease
- Calcium Activated Neutral Protease
- Neutral Protease, Calcium-Activated
- Protease, Calcium-Activated Neutral
|
Below are MeSH descriptors whose meaning is more general than "Calpain".
Below are MeSH descriptors whose meaning is more specific than "Calpain".
This graph shows the total number of publications written about "Calpain" by people in this website by year, and whether "Calpain" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 2000 | 1 | 0 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 3 | 3 |
| 2007 | 1 | 1 | 2 |
| 2009 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 1 | 2 |
| 2012 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 2 | 0 | 2 |
| 2016 | 1 | 1 | 2 |
| 2018 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Calpain" by people in Profiles.
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Targeting calpain-2-mediated junctophilin-2 cleavage delays heart failure progression following myocardial infarction. J Mol Cell Cardiol. 2024 Sep; 194:85-95.
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Characterization of Calpain and Caspase-6-Generated Glial Fibrillary Acidic Protein Breakdown Products Following Traumatic Brain Injury and Astroglial Cell Injury. Int J Mol Sci. 2022 Aug 11; 23(16).
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Calpain-2 regulates hypoxia/HIF-induced plasticity toward amoeboid cancer cell migration and metastasis. Curr Biol. 2022 01 24; 32(2):412-427.e8.
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Quantitative dissection of multilocus pathogenic variation in an Egyptian infant with severe neurodevelopmental disorder resulting from multiple molecular diagnoses. Am J Med Genet A. 2022 03; 188(3):735-750.
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Nuclear localization of a novel calpain-2 mediated junctophilin-2 C-terminal cleavage peptide promotes cardiomyocyte remodeling. Basic Res Cardiol. 2020 06 26; 115(4):49.
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Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury. J Mol Cell Cardiol. 2019 04; 129:236-246.
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Rbfox-Splicing Factors Maintain Skeletal Muscle Mass by Regulating Calpain3 and Proteostasis. Cell Rep. 2018 07 03; 24(1):197-208.
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Attenuation of Blood-Brain Barrier Breakdown and Hyperpermeability by Calpain Inhibition. J Biol Chem. 2016 12 30; 291(53):26958-26969.
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Dysfunction of the ?2-spectrin-based pathway in human heart failure. Am J Physiol Heart Circ Physiol. 2016 06 01; 310(11):H1583-91.
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aB-crystallin interacts with and prevents stress-activated proteolysis of focal adhesion kinase by calpain in cardiomyocytes. Nat Commun. 2014 Oct 16; 5:5159.