"Cathepsin B" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A lysosomal cysteine proteinase with a specificity similar to that of PAPAIN. The enzyme is present in a variety of tissues and is important in many physiological and pathological processes. In pathology, cathepsin B has been found to be involved in DEMYELINATION; EMPHYSEMA; RHEUMATOID ARTHRITIS, and NEOPLASM INVASIVENESS.
| Descriptor ID |
D002401
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| MeSH Number(s) |
D08.811.277.656.224.125 D08.811.277.656.262.500.133 D08.811.277.656.300.200.133
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cathepsin B".
Below are MeSH descriptors whose meaning is more specific than "Cathepsin B".
This graph shows the total number of publications written about "Cathepsin B" by people in this website by year, and whether "Cathepsin B" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2020 | 2 | 0 | 2 |
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Below are the most recent publications written about "Cathepsin B" by people in Profiles.
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Uncloaking cell-impermeant gold nanorods via tumor microenvironmental cathepsin B facilitates cancer cell penetration and potent radiosensitization. Biomaterials. 2022 12; 291:121887.
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Penetrating Traumatic Brain Injury Triggers Dysregulation of Cathepsin B Protein Levels Independent of Cysteine Protease Activity in Brain and Cerebral Spinal Fluid. J Neurotrauma. 2020 07 01; 37(13):1574-1586.
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Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia. Brain. 2020 01 01; 143(1):234-248.
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Cathepsin B-Mediated NLRP3 Inflammasome Formation and Activation in Angiotensin II -Induced Hypertensive Mice: Role of Macrophage Digestion Dysfunction. Cell Physiol Biochem. 2018; 50(4):1585-1600.
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Endothelial Nlrp3 inflammasome activation associated with lysosomal destabilization during coronary arteritis. Biochim Biophys Acta. 2015 Feb; 1853(2):396-408.
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Inflammasome activation by altered proteostasis. J Biol Chem. 2013 Dec 13; 288(50):35886-95.
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Photodynamic therapy using a protease-mediated theranostic agent reduces cathepsin-B activity in mouse atheromata in vivo. Arterioscler Thromb Vasc Biol. 2013 Jun; 33(6):1360-5.
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Small-molecule inhibitors of cathepsin L incorporating functionalized ring-fused molecular frameworks. Bioorg Med Chem Lett. 2013 May 01; 23(9):2801-7.
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Cellular and molecular evidence for malignancy-inhibitory functions of p15RS. Cell Cycle. 2012 May 15; 11(10):1988-98.
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Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18637-42.