"Caspases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
| Descriptor ID |
D020169
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| MeSH Number(s) |
D08.811.277.656.262.500.126 D08.811.277.656.300.200.126 D12.644.360.075.405 D12.776.476.075.405
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Caspases".
Below are MeSH descriptors whose meaning is more specific than "Caspases".
This graph shows the total number of publications written about "Caspases" by people in this website by year, and whether "Caspases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 4 | 1 | 5 |
| 1999 | 3 | 2 | 5 |
| 2000 | 5 | 5 | 10 |
| 2001 | 2 | 3 | 5 |
| 2002 | 6 | 4 | 10 |
| 2003 | 2 | 6 | 8 |
| 2004 | 3 | 11 | 14 |
| 2005 | 2 | 17 | 19 |
| 2006 | 2 | 7 | 9 |
| 2007 | 1 | 5 | 6 |
| 2008 | 1 | 1 | 2 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 3 | 4 |
| 2011 | 1 | 2 | 3 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 1 | 2 |
| 2015 | 5 | 2 | 7 |
| 2016 | 1 | 3 | 4 |
| 2017 | 1 | 1 | 2 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 1 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 3 | 1 | 4 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Caspases" by people in Profiles.
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Recurrent acquisition of nuclease-protease pairs in antiviral immunity. Science. 2026 Jan 08; 391(6781):195-201.
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The Effect of the Classical TSPO Ligand PK 11195 on In Vitro Cobalt Chloride Model of Hypoxia-like Condition in Lung and Brain Cell Lines. Biomolecules. 2022 Sep 29; 12(10).
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Lethal and Non-Lethal Functions of Caspases in the DNA Damage Response. Cells. 2022 06 10; 11(12).
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Visualization of Inflammatory Caspases Induced Proximity in Human Monocyte-Derived Macrophages. J Vis Exp. 2022 04 06; (182).
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Cellular autophagy, an unbidden effect of caspase inhibition by zVAD-fmk. FEBS J. 2022 06; 289(11):3097-3100.
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Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1? Release and Cell Death. J Immunol. 2021 04 15; 206(8):1878-1889.
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Targeting apoptotic caspases in cancer. Biochim Biophys Acta Mol Cell Res. 2020 06; 1867(6):118688.
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Inflammatory caspase regulation: maintaining balance between inflammation and cell death in health and disease. FEBS J. 2019 07; 286(14):2628-2644.
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Stem cell proliferation is induced by apoptotic bodies from dying cells during epithelial tissue maintenance. Nat Commun. 2019 03 05; 10(1):1044.
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Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation. J Vis Exp. 2018 03 05; (133).