Apoptosis Inducing Factor
"Apoptosis Inducing Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.
| Descriptor ID |
D051033
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| MeSH Number(s) |
D08.811.682.608.047 D12.644.360.075.311 D12.776.157.687.063 D12.776.331.161 D12.776.476.075.311 D12.776.660.720.063
|
| Concept/Terms |
Apoptosis Inducing Factor- Apoptosis Inducing Factor
- Apoptosis-Inducing Factor
- Mitochondrial Apoptosis-Inducing Factor
- Apoptosis-Inducing Factor, Mitochondrial
- Mitochondrial Apoptosis Inducing Factor
- AIF Apoptosis Regulatory Protein
|
Below are MeSH descriptors whose meaning is more general than "Apoptosis Inducing Factor".
Below are MeSH descriptors whose meaning is more specific than "Apoptosis Inducing Factor".
This graph shows the total number of publications written about "Apoptosis Inducing Factor" by people in this website by year, and whether "Apoptosis Inducing Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Apoptosis Inducing Factor" by people in Profiles.
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Chemical screening by time-resolved X-ray scattering to discover allosteric probes. Nat Chem Biol. 2024 Sep; 20(9):1199-1209.
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What Combined Measurements From Structures and Imaging Tell Us About DNA Damage Responses. Methods Enzymol. 2017; 592:417-455.
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Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor. Structure. 2016 12 06; 24(12):2067-2079.
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Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells. Apoptosis. 2014 Jan; 19(1):241-58.
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Apicularen A acetate induces cell death via AIF translocation and disrupts the microtubule network by down-regulating tubulin in HM7 human colon cancer cells. Biochem Biophys Res Commun. 2013 May 10; 434(3):634-40.
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Combination of atiprimod and the proteasome inhibitor bortezomib induces apoptosis of mantle cell lymphoma in vitro and in vivo. Leuk Res. 2012 Mar; 36(3):363-8.
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Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia. J Neurochem. 2010 May; 113(4):1012-22.
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Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells. Blood. 2008 Sep 01; 112(5):1971-80.
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The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces caspase-dependent and -independent apoptosis in acute myelogenous leukemia. Cancer Res. 2004 Nov 01; 64(21):7927-35.
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The mitochondrial apoptosis-inducing factor plays a role in E2F-1-induced apoptosis in human colon cancer cells. Ann Surg Oncol. 2003 Apr; 10(3):314-22.