Cytochrome-B(5) Reductase
"Cytochrome-B(5) Reductase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA.
| Descriptor ID |
D042966
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| MeSH Number(s) |
D08.811.682.608.191.237 D12.776.331.186
|
| Concept/Terms |
Cytochrome-B(5) Reductase- Cytochrome-B(5) Reductase
- NADH-Cytochrome B5 Reductase
- B5 Reductase, NADH-Cytochrome
- NADH Cytochrome B5 Reductase
Methemoglobin Reductase- Methemoglobin Reductase
- Reductase, Methemoglobin
- NADH-Ferrihemoglobin Reductase
- NADH Ferrihemoglobin Reductase
- Reductase, NADH-Ferrihemoglobin
- NADH Methemoglobin Reductase
- Methemoglobin Reductase, NADH
- Reductase, NADH Methemoglobin
|
Below are MeSH descriptors whose meaning is more general than "Cytochrome-B(5) Reductase".
Below are MeSH descriptors whose meaning is more specific than "Cytochrome-B(5) Reductase".
This graph shows the total number of publications written about "Cytochrome-B(5) Reductase" by people in this website by year, and whether "Cytochrome-B(5) Reductase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cytochrome-B(5) Reductase" by people in Profiles.
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Cytochrome P450 reductase (POR) as a ferroptosis fuel. Protein Cell. 2021 09; 12(9):675-679.
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Structure and Mechanism of a Unique Diiron Center in Mammalian Stearoyl-CoA Desaturase. J Mol Biol. 2020 08 21; 432(18):5152-5161.
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P450 redox enzymes in the white rot fungus Phanerochaete chrysosporium: gene transcription, heterologous expression, and activity analysis on the purified proteins. Curr Microbiol. 2010 Oct; 61(4):306-14.
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Methemoglobinemia in a young man. Tex Heart Inst J. 2008; 35(1):76-7.
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A novel mutation of the cytochrome-b5 reductase gene in an Indian patient: the molecular basis of type I methemoglobinemia. Haematologica. 2006 Nov; 91(11):1542-5.
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NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum. J Biol Chem. 2004 Jul 16; 279(29):30316-25.