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AMOS GAIKWAD

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Stevens AM, Terrell M, Rashid R, Fisher KE, Marcogliese AN, Gaikwad A, Rao P, Vrana C, Krueger M, Loken M, Menssen AJ, Cook JA, Keogh N, Alozie M, Oviedo H, Gonzalez AK, Ilangovan T, Kim J, Sandhu S, Redell MS. Addressing a Pre-Clinical Pipeline Gap: Development of the Pediatric Acute Myeloid Leukemia Patient-Derived Xenograft Program at Texas Children's Hospital at Baylor College of Medicine. Biomedicines. 2024 Feb 08; 12(2). PMID: 38397996; PMCID: PMC10886789.
      Citations:    
    2. Thapa S, Shankar N, Shrestha AK, Civunigunta M, Gaikwad AS, Shivanna B. Amphiregulin Exerts Proangiogenic Effects in Developing Murine Lungs. Antioxidants (Basel). 2024 Jan 08; 13(1). PMID: 38247502; PMCID: PMC10812697.
      Citations:    
    3. Chen Wongworawat Y, Eskandari G, Gaikwad A, Marcogliese AN, Ferguson LS, Brackett J, Punia JN, Elghetany MT, Kulkarni R, Rao PH, Ringrose J, Lopez-Terrada DH, Roy A, Curry CV, Fisher KE. Frequent detection of CBFA2T3::GLIS2 fusion and RAM-phenotype in pediatric non-Down syndrome acute megakaryoblastic leukemia: a possible novel relationship with aberrant cytoplasmic CD3 expression. Leuk Lymphoma. 2023 02; 64(2):462-467. PMID: 36346368.
      Citations: 1     Fields:    Translation:Humans
    4. Tovy A, Rosas C, Gaikwad AS, Medrano G, Zhang L, Reyes JM, Huang YH, Arakawa T, Kurtz K, Conneely SE, Guzman AG, Aguilar R, Gao A, Chen CW, Kim JJ, Carter MT, Lasa-Aranzasti A, Valenzuela I, Brunetti L, Hicks MJ, Marcogliese AN, Goodell MA, Rau RE, Van Maldergem L. Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome. Haematologica. 2022 04 01; 107(4):887-898. PMID: 34092059; PMCID: PMC8968878.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    5. Man TK, Aubert G, Richard MA, LeJeune W, Hariri E, Goltsova T, Gaikwad A, Chen Y, Whitton J, Leisenring WM, Arnold MA, Neglia JP, Yasui Y, Robison LL, Armstrong GT, Bhatia S, Gramatges MM. Short NK- and Na?ve T-Cell Telomere Length Is Associated with Thyroid Cancer in Childhood Cancer Survivors: A Report from the Childhood Cancer Survivor Study. Cancer Epidemiol Biomarkers Prev. 2022 02; 31(2):453-460. PMID: 34782395; PMCID: PMC8825729.
      Citations:    Fields:    Translation:HumansCells
    6. Yost CM, Gaikwad AS, Parsons DW, Rabin KR, Gant VU, Fisher KE, Marcogliese AN, Schafer ES. Aberrant leukemia-associated immunophenotype as potential harbinger of lineage switch in KMT2A-rearranged leukemia: a case series. Leuk Lymphoma. 2020 12; 61(14):3515-3518. PMID: 32876512.
      Citations:    Fields:    Translation:Humans
    7. Stevens AM, Xiang M, Heppler LN, Jiang K, Munoz JO, Gaikwad AS, Horton TM, Long X, Narayanan P, Seashore EL, Terrell MC, Rashid R, Krueger MJ, Mangubat-Medina AE, Ball ZT, Sumazin P, Walker SR, Hamada Y, Oyadomari S, Redell MS, Frank DA, To?ic I. Atovaquone is active against AML by upregulating the integrated stress pathway and suppressing oxidative phosphorylation. Blood Adv. 2019 12 23; 3(24):4215-4227. PMID: 31856268; PMCID: PMC6929386.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    8. Hashmi SK, Punia JN, Marcogliese AN, Gaikwad AS, Fisher KE, Roy A, Rao P, Lopez-Terrada DH, Ringrose J, Loh ML, Niemeyer CM, Rau RE. Sustained remission with azacitidine monotherapy and an aberrant precursor B-lymphoblast population in juvenile myelomonocytic leukemia. Pediatr Blood Cancer. 2019 10; 66(10):e27905. PMID: 31250550; PMCID: PMC7328527.
      Citations: 3     Fields:    Translation:HumansCells
    9. Coffey AM, Lewis A, Marcogliese AN, Elghetany MT, Punia JN, Chang CC, Allen CE, McClain KL, Gaikwad AS, El-Mallawany NK, Curry CV. A clinicopathologic study of the spectrum of systemic forms of EBV-associated T-cell lymphoproliferative disorders of childhood: A single tertiary care pediatric institution experience in North America. Pediatr Blood Cancer. 2019 08; 66(8):e27798. PMID: 31099136.
      Citations: 3     Fields:    Translation:HumansCellsCTClinical Trials
    10. Namazzi R, Gaikwad A, Wasswa P, Cubbage M, Kambugu JB, Kasirye P, Geriga F, Allen C, Lubega J. Improving diagnosis and treatment of acute childhood leukemia in Uganda: impact of flow cytometry. Blood Adv. 2018 11 30; 2(Suppl 1):21-23. PMID: 30504192; PMCID: PMC6438277.
      Citations: 1     Fields:    Translation:Humans
    11. Long DJ, Gaikwad A, Multani A, Pathak S, Montgomery CA, Gonzalez FJ, Jaiswal AK. Retraction: Disruption of the NAD(P)H:Quinone Oxidoreductase 1 (NQO1) Gene in Mice Causes Myelogenous Hyperplasia. Cancer Res. 2018 Nov 15; 78(22):6526. PMID: 30442815.
      Citations:    Fields:    
    12. Arasaratnam RJ, Tzannou I, Gray T, Aguayo-Hiraldo PI, Kuvalekar M, Naik S, Gaikwad A, Liu H, Miloh T, Vera JF, Himes RW, Munoz FM, Leen AM. Dynamics of virus-specific T cell immunity in pediatric liver transplant recipients. Am J Transplant. 2018 09; 18(9):2238-2249. PMID: 29900673; PMCID: PMC6117219.
      Citations: 2     Fields:    Translation:HumansCellsCTClinical Trials
    13. Punia JN, Gaikwad A, Hampton OA, Heczey A, Whittle SB, L?pez-Terrada D. Therapy-related Acute Leukemia With Mixed Phenotype and Novel t(1: 6)(q25;p23) After Treatment for High-risk Neuroblastoma. J Pediatr Hematol Oncol. 2017 11; 39(8):e486-e488. PMID: 28902076.
      Citations:    Fields:    Translation:HumansCells
    14. Stevens AM, Miller JM, Munoz JO, Gaikwad AS, Redell MS. Interleukin-6 levels predict event-free survival in pediatric AML and suggest a mechanism of chemotherapy resistance. Blood Adv. 2017 Aug 08; 1(18):1387-1397. PMID: 29296780; PMCID: PMC5727855.
      Citations: 22     Fields:    
    15. Bonifant CL, Szoor A, Torres D, Joseph N, Velasquez MP, Iwahori K, Gaikwad A, Nguyen P, Arber C, Song XT, Redell M, Gottschalk S. CD123-Engager T Cells as a Novel Immunotherapeutic for Acute Myeloid Leukemia. Mol Ther. 2016 09 29; 24(9):1615-26. PMID: 27401038; PMCID: PMC5113097.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    16. Gaikwad A, Bonifant CL, Cubbage M, Goltsova T, Mudannayake M, Ringrose J, Punia J, Lopez-Terrada D, Sheehan AM. Detection of lymphoid and myeloid lineages in infantile B-cell acute lymphoblastic leukemia with mixed-lineage leukemia rearrangement by use of flow cytometry and cytogenetic analysis. Clin Lymphoma Myeloma Leuk. 2014 Sep; 14 Suppl:S2-5. PMID: 25486951.
      Citations:    Fields:    Translation:HumansCells
    17. Gaikwad AS, Donohue RE, Elghetany MT, Sheehan AM, Lu XY, Gramatges MM, McClain KL, Mistretta TA, Punia JN, Moore TJ, Goltsova T, Cubbage M, Curry CV. Expression of CD25 is a specific and relatively sensitive marker for the Philadelphia chromosome (BCR-ABL1) translocation in pediatric B acute lymphoblastic leukemia. Int J Clin Exp Pathol. 2014; 7(9):6225-30. PMID: 25337274; PMCID: PMC4203245.
      Citations: 4     Fields:    Translation:HumansCells
    18. Manshouri T, Estrov Z, Harris D, Zhang Y, Gaikwad A, Kantarjian HM, Verstovsek S, Quint?s-Cardama A. Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor. Invest New Drugs. 2011 Oct; 29(5):818-26. PMID: 20372971; PMCID: PMC4170651.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    19. Allen CE, Li L, Peters TL, Leung HC, Yu A, Man TK, Gurusiddappa S, Phillips MT, Hicks MJ, Gaikwad A, Merad M, McClain KL. Cell-specific gene expression in Langerhans cell histiocytosis lesions reveals a distinct profile compared with epidermal Langerhans cells. J Immunol. 2010 Apr 15; 184(8):4557-67. PMID: 20220088; PMCID: PMC3142675.
      Citations: 98     Fields:    Translation:HumansCells
    20. Gaikwad A, Rye CL, Devidas M, Heerema NA, Carroll AJ, Izraeli S, Plon SE, Basso G, Pession A, Rabin KR. Prevalence and clinical correlates of JAK2 mutations in Down syndrome acute lymphoblastic leukaemia. Br J Haematol. 2009 Mar; 144(6):930-2. PMID: 19120350; PMCID: PMC2724897.
      Citations: 37     Fields:    Translation:HumansCells
    21. Manshouri T, Nussenzveig RH, Gaikwad A, Estrov Z, Prchal J, Cortes JE, Kantarjian HM, Verstovsek S, Quint?s-Cardama A. The JAK kinase inhibitor CP-690,550 suppresses the growth of human polycythemia vera cells carrying the JAK2V617F mutation. Cancer Sci. 2008 Jun; 99(6):1265-73. PMID: 18482053; PMCID: PMC4829954.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    22. Zhang C, Li B, Gaikwad AS, Haridas V, Xu Z, Gutterman JU, Duvic M. Avicin D selectively induces apoptosis and downregulates p-STAT-3, bcl-2, and survivin in cutaneous T-cell lymphoma cells. J Invest Dermatol. 2008 Nov; 128(11):2728-2735. PMID: 18496567.
      Citations: 18     Fields:    Translation:HumansCells
    23. Agarwal N, Kutlar F, Mojica-Henshaw MP, Ou CN, Gaikwad A, Reading NS, Bailey L, Kutlar A, Prchal JT. Missense mutation of the last nucleotide of exon 1 (G->C) of beta globin gene not only leads to undetectable mutant peptide and transcript but also interferes with the expression of wild allele. Haematologica. 2007 Dec; 92(12):1715-6. PMID: 18056002.
      Citations: 3     Fields:    Translation:HumansCells
    24. Gaikwad A, Prchal JT. Study of two tyrosine kinase inhibitors on growth and signal transduction in polycythemia vera. Exp Hematol. 2007 Nov; 35(11):1647-56. PMID: 17976517; PMCID: PMC2206678.
      Citations: 2     Fields:    Translation:HumansCells
    25. Xu ZX, Liang J, Haridas V, Gaikwad A, Connolly FP, Mills GB, Gutterman JU. A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase. Cell Death Differ. 2007 Nov; 14(11):1948-57. PMID: 17690712.
      Citations: 36     Fields:    Translation:HumansCells
    26. Gaikwad A, Verstovsek S, Yoon D, Chang KT, Manshouri T, Nussenzveig R, Cortes J, Vainchenker W, Prchal JT. Imatinib effect on growth and signal transduction in polycythemia vera. Exp Hematol. 2007 Jun; 35(6):931-8. PMID: 17533047.
      Citations: 11     Fields:    Translation:HumansCells
    27. Gaikwad A, Nussenzveig R, Liu E, Gottshalk S, Chang K, Prchal JT. In vitro expansion of erythroid progenitors from polycythemia vera patients leads to decrease in JAK2 V617F allele. Exp Hematol. 2007 Apr; 35(4):587-95. PMID: 17379069; PMCID: PMC1931508.
      Citations: 19     Fields:    Translation:HumansCells
    28. Nussenzveig RH, Swierczek SI, Jelinek J, Gaikwad A, Liu E, Verstovsek S, Prchal JF, Prchal JT. Polycythemia vera is not initiated by JAK2V617F mutation. Exp Hematol. 2007 Jan; 35(1):32-8. PMID: 17198871.
      Citations: 85     Fields:    Translation:HumansCells
    29. Nussenzveig RH, Lingam HB, Gaikwad A, Zhu Q, Jing N, Prchal JT. A novel mutation of the cytochrome-b5 reductase gene in an Indian patient: the molecular basis of type I methemoglobinemia. Haematologica. 2006 Nov; 91(11):1542-5. PMID: 17082011.
      Citations: 3     Fields:    Translation:Humans
    30. Gutterman JU, Lai HT, Yang P, Haridas V, Gaikwad A, Marcus S. Effects of the tumor inhibitory triterpenoid avicin G on cell integrity, cytokinesis, and protein ubiquitination in fission yeast. Proc Natl Acad Sci U S A. 2005 Sep 06; 102(36):12771-6. PMID: 16118282; PMCID: PMC1200287.
      Citations: 6     Fields:    Translation:AnimalsCells
    31. Iskander K, Gaikwad A, Paquet M, Long DJ, Brayton C, Barrios R, Jaiswal AK. Lower induction of p53 and decreased apoptosis in NQO1-null mice lead to increased sensitivity to chemical-induced skin carcinogenesis. Cancer Res. 2005 Mar 15; 65(6):2054-8. PMID: 15781611.
      Citations: 36     Fields:    Translation:AnimalsCells
    32. Gaikwad A, Poblenz A, Haridas V, Zhang C, Duvic M, Gutterman J. Triterpenoid electrophiles (avicins) suppress heat shock protein-70 and x-linked inhibitor of apoptosis proteins in malignant cells by activation of ubiquitin machinery: implications for proapoptotic activity. Clin Cancer Res. 2005 Mar 01; 11(5):1953-62. PMID: 15756021.
      Citations: 16     Fields:    Translation:HumansCells
    33. Stringer JL, Gaikwad A, Gonzales BN, Long DJ, Marks LM, Jaiswal AK. Presence and induction of the enzyme NAD(P)H: quinone oxidoreductase 1 in the central nervous system. J Comp Neurol. 2004 Apr 05; 471(3):289-97. PMID: 14991562.
      Citations: 13     Fields:    Translation:Animals
    34. Haridas V, Hanausek M, Nishimura G, Soehnge H, Gaikwad A, Narog M, Spears E, Zoltaszek R, Walaszek Z, Gutterman JU. Triterpenoid electrophiles (avicins) activate the innate stress response by redox regulation of a gene battery. J Clin Invest. 2004 Jan; 113(1):65-73. PMID: 14702110; PMCID: PMC300766.
      Citations: 25     Fields:    Translation:HumansCells
    35. Long DJ, Iskander K, Gaikwad A, Arin M, Roop DR, Knox R, Barrios R, Jaiswal AK. Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity. J Biol Chem. 2002 Nov 29; 277(48):46131-9. PMID: 12351651.
      Citations: 31     Fields:    Translation:AnimalsCells
    36. Gaikwad A, Hop DV, Mukherjee SK. A 70-kDa chloroplast DNA polymerase from pea ( Pisum sativum) that shows high processivity and displays moderate fidelity. Mol Genet Genomics. 2002 Mar; 267(1):45-56. PMID: 11919714.
      Citations: 3     Fields:    Translation:AnimalsCells
    37. Gaikwad A, Long DJ, Stringer JL, Jaiswal AK. In vivo role of NAD(P)H:quinone oxidoreductase 1 (NQO1) in the regulation of intracellular redox state and accumulation of abdominal adipose tissue. J Biol Chem. 2001 Jun 22; 276(25):22559-64. PMID: 11309386.
      Citations: 73     Fields:    Translation:AnimalsCells
    38. Gaikwad A, Van Hop D, Mukherjee SK. Carboxy terminal region of a chloroplast DNA polymerase accessory factor stimulates DNA polymerase activity. Indian J Biochem Biophys. 2000 Dec; 37(6):424-32. PMID: 11355629.
      Citations: 1     Fields:    Translation:Cells
    39. Gaikwad A, Babbarwal V, Pant V, Mukherjee SK. Pea chloroplast FtsZ can form multimers and correct the thermosensitive defect of an Escherichia coli ftsZ mutant. Mol Gen Genet. 2000 Mar; 263(2):213-21. PMID: 10778739.
      Citations: 11     Fields:    Translation:AnimalsCells
    40. Ehtesham NZ, Phan TN, Gaikwad A, Sopory SK, Tuteja N. Calnexin from Pisum sativum: cloning of the cDNA and characterization of the encoded protein. DNA Cell Biol. 1999 Nov; 18(11):853-62. PMID: 10595399.
      Citations: 7     Fields:    Translation:AnimalsCells
    41. Gaikwad A, Tewari KK, Kumar D, Chen W, Mukherjee SK. Isolation and characterisation of the cDNA encoding a glycosylated accessory protein of pea chloroplast DNA polymerase. Nucleic Acids Res. 1999 Aug 01; 27(15):3120-9. PMID: 10454608; PMCID: PMC148538.
      Citations: 7     Fields:    Translation:AnimalsCells
    42. Gaikwad A, Yadav BS, Reddy MK, Sopory S, Mukherjee SK. Suppression of pea nuclear topoisomerase I enzyme activity by pea PCNA. Plant J. 1999 Jul; 19(2):153-162. PMID: 10476062.
      Citations: 1     Fields:    
    43. Chen W, Gaikwad A, Mukherjee SK, Choudhary NR, Kumar D, Tewari KK. A 43 kDa DNA binding protein from the pea chloroplast interacts with and stimulates the cognate DNA polymerase. Nucleic Acids Res. 1996 Oct 15; 24(20):3953-61. PMID: 8918797; PMCID: PMC146191.
      Citations: 4     Fields:    Translation:AnimalsCells
    44. Omkumar RV, Gaikwad AS, Ramasarma T. Feedback-type inhibition of activity of 3-hydroxy-3-methylglutaryl coenzyme a reductase by ubiquinone. Biochem Biophys Res Commun. 1992 May 15; 184(3):1280-7. PMID: 1590790.
      Citations: 2     Fields:    Translation:AnimalsCells
    45. Ramasarma T, Rasheed BK, Vijaya S, Puranam RS, Shivaswamy V, Gaikwad AS, Kurup CK. Functions of cytochrome c in regulation of electron transfer and protein folding. Indian J Biochem Biophys. 1992 Apr; 29(2):173-8. PMID: 1328035.
      Citations:    Fields:    Translation:AnimalsCells
    46. Gaikwad AS, Ramasarma T, Ramakrishna Kurup CK. Brown adipose tissue mitochondria are cytochrome c-subsaturated. Mol Cell Biochem. 1991 Jul 10; 105(2):119-25. PMID: 1656204.
      Citations: 2     Fields:    Translation:AnimalsCells
    47. Gaikwad A, Ramasarma T, Kurup CK. Regulation of respiratory activity of brown adipose tissue mitochondria through changes in cytochromes. Biotechnol Appl Biochem. 1990 Oct; 12(5):562-6. PMID: 2288713.
      Citations:    Fields:    Translation:AnimalsCells
    48. Gaikwad AS, Ramasarma T, Kurup CK. Decrease of oxidative activities in brown adipose tissue mitochondria of cold acclimated rats on short term exposure to heat stress. Biochim Biophys Acta. 1990 Jun 26; 1017(3):242-50. PMID: 2372558.
      Citations: 1     Fields:    Translation:AnimalsCells
    49. Gaikwad AS, Ramasarma T, Kurup CK. Changes in thyroid hormone and insulin status of the brown adipose tissue of cold acclimated rats on short term exposure to heat. Indian J Biochem Biophys. 1990 Jun; 27(3):167-71. PMID: 2201623.
      Citations:    Fields:    Translation:Animals
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