"NADPH Oxidases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of membrane-associated flavoprotein NADPH-dependent oxidoreductases that catalyze the univalent reduction of OXYGEN to create SUPEROXIDES. Structurally, they are characterized by six N-terminal transmembrane ALPHA-HELICES, a FLAVIN-ADENINE DINUCLEOTIDE (FAD)-binding region, and a C-terminal NADPH-binding region. They are expressed primarily by EPITHELIAL CELLS in gut, kidney, colon, and smooth muscle tissues, as well as GRANULOCYTES and function to transfer electrons across membranes to molecular oxygen. Defects in the production of superoxide ions by some NADPH oxidases result in GRANULOMATOUS DISEASE, CHRONIC.
| Descriptor ID |
D019255
|
| MeSH Number(s) |
D08.811.682.608.575 D12.776.331.894 D12.776.543.653
|
| Concept/Terms |
NADPH Oxidases- NADPH Oxidases
- Oxidases, NADPH
- NAD(P)H oxidase
- NADPH Oxidase
- Oxidase, NADPH
- Nox Proteins
- NAD(P)H Oxidases
|
Below are MeSH descriptors whose meaning is more general than "NADPH Oxidases".
Below are MeSH descriptors whose meaning is more specific than "NADPH Oxidases".
This graph shows the total number of publications written about "NADPH Oxidases" by people in this website by year, and whether "NADPH Oxidases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 1 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 4 | 2 | 6 |
| 2007 | 0 | 3 | 3 |
| 2008 | 1 | 5 | 6 |
| 2009 | 5 | 3 | 8 |
| 2010 | 5 | 5 | 10 |
| 2011 | 3 | 7 | 10 |
| 2012 | 6 | 6 | 12 |
| 2013 | 2 | 6 | 8 |
| 2014 | 1 | 3 | 4 |
| 2015 | 1 | 1 | 2 |
| 2016 | 3 | 1 | 4 |
| 2017 | 0 | 2 | 2 |
| 2018 | 0 | 1 | 1 |
| 2020 | 0 | 3 | 3 |
| 2021 | 0 | 2 | 2 |
| 2022 | 1 | 1 | 2 |
| 2023 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "NADPH Oxidases" by people in Profiles.
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NADPH oxidase overexpression and mitochondrial OxPhos impairment are more profound in human hearts donated after circulatory death than brain death. Am J Physiol Heart Circ Physiol. 2024 Mar 01; 326(3):H548-H562.
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Contribution of membrane raft redox signalling to visfatin-induced inflammasome activation and podocyte injury. Aging (Albany NY). 2023 11 17; 15(22):12738-12748.
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BMAL1 modulates ROS generation and insulin secretion in pancreatic ?-cells: An effect possibly mediated via NOX2. Mol Cell Endocrinol. 2022 09 15; 555:111725.
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Chronic Granulomatous Disease-Like Presentation of a Child with Autosomal Recessive PKCd Deficiency. J Clin Immunol. 2022 08; 42(6):1244-1253.
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Imaging of innate immunity activation in vivo with a redox-tuned PET reporter. Nat Biotechnol. 2022 06; 40(6):965-973.
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The genetic underpinnings of anthracycline-induced cardiomyopathy predisposition. Clin Genet. 2021 08; 100(2):132-143.
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Listeria monocytogenes upregulates mitochondrial calcium signalling to inhibit LC3-associated phagocytosis as a survival strategy. Nat Microbiol. 2021 03; 6(3):366-379.
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Nox4 - RyR1 - Nox2: Regulators of micro-domain signaling in skeletal muscle. Redox Biol. 2020 09; 36:101557.
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Sorting nexin 1 loss results in increased oxidative stress and hypertension. FASEB J. 2020 06; 34(6):7941-7957.
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Roscovitine enhances All-trans retinoic acid (ATRA)-induced leukemia cell differentiation: Novel effects on signaling molecules for a putative Cdk2 inhibitor. Cell Signal. 2020 07; 71:109555.