Electron Transport Complex I
"Electron Transport Complex I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A flavoprotein and iron sulfur-containing oxidoreductase complex that catalyzes the conversion of UBIQUINONE to ubiquinol. In MITOCHONDRIA the complex also couples its reaction to the transport of PROTONS across the internal mitochondrial membrane. The NADH DEHYDROGENASE component of the complex can be isolated and is listed as EC 1.6.99.3.
| Descriptor ID |
D042967
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| MeSH Number(s) |
D05.500.562.249 D08.811.600.250.500.500 D08.811.682.608.504 D12.776.157.427.374.375.863 D12.776.157.530.450.250.875.300 D12.776.331.199.500 D12.776.543.277.500.500 D12.776.543.585.450.250.875.437 D12.776.556.579.374.375.140
|
| Concept/Terms |
NADH Dehydrogenase (Ubiquinone)- NADH Dehydrogenase (Ubiquinone)
- NADH Dehydrogenase Complex 1
- NADH Dehydrogenase I
- NADH DH I
- Ubiquinone Reductase
- NADH-Coenzyme Q Reductase
- NADH Coenzyme Q Reductase
- NADH-CoQ Reductase
- NADH CoQ Reductase
- NADH-Ubiquinone Oxidoreductase
- NADH Ubiquinone Oxidoreductase
- Oxidoreductase, NADH-Ubiquinone
- NADH-Ubiquinone Reductase
- NADH Ubiquinone Reductase
- Reductase, NADH-Ubiquinone
- Rotenone-Sensitive Mitochondrial NADH-Ubiquinone Oxidoreductase
- Rotenone Sensitive Mitochondrial NADH Ubiquinone Oxidoreductase
- Complex I Dehydrogenase
- Dehydrogenase, Complex I
- NADH Q1 Oxidoreductase
- Oxidoreductase, NADH Q1
|
Below are MeSH descriptors whose meaning is more general than "Electron Transport Complex I".
Below are MeSH descriptors whose meaning is more specific than "Electron Transport Complex I".
This graph shows the total number of publications written about "Electron Transport Complex I" by people in this website by year, and whether "Electron Transport Complex I" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 2 | 2 | 4 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 1 | 1 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Electron Transport Complex I" by people in Profiles.
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Mitochondrial reprogramming by activating OXPHOS via glutamine metabolism in African American patients with bladder cancer. JCI Insight. 2024 Sep 10; 9(17).
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Mitochondrial complex I promotes kidney cancer metastasis. Nature. 2024 Sep; 633(8031):923-931.
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Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers. Mol Cell. 2024 May 16; 84(10):1964-1979.e6.
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NDUFS4 regulates cristae remodeling in diabetic kidney disease. Nat Commun. 2024 Mar 04; 15(1):1965.
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Enhanced Succinate Oxidation with Mitochondrial Complex II Reactive Oxygen Species Generation in Human Prostate Cancer. Int J Mol Sci. 2022 Oct 12; 23(20).
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Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia. Nat Commun. 2022 05 19; 13(1):2801.
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Patient-derived iPSCs link elevated mitochondrial respiratory complex I function to osteosarcoma in Rothmund-Thomson syndrome. PLoS Genet. 2021 12; 17(12):e1009971.
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First-in-human evaluation of the novel mitochondrial complex I inhibitor ASP4132 for treatment of cancer. Invest New Drugs. 2021 10; 39(5):1348-1356.
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Tead1 is essential for mitochondrial function in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2020 07 01; 319(1):H89-H99.
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Validation of a mitochondrial RNA therapeutic strategy using fibroblasts from a Leigh syndrome patient with a mutation in the mitochondrial ND3 gene. Sci Rep. 2020 05 05; 10(1):7511.