"Ferrochelatase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitochondrial enzyme found in a wide variety of cells and tissues. It is the final enzyme in the 8-enzyme biosynthetic pathway of HEME. Ferrochelatase catalyzes ferrous insertion into protoporphyrin IX to form protoheme or heme. Deficiency in this enzyme results in ERYTHROPOIETIC PROTOPORPHYRIA.
| Descriptor ID |
D005294
|
| MeSH Number(s) |
D08.811.520.500 D12.776.157.427.374.375.957 D12.776.556.579.374.375.617 D12.776.575.562
|
| Concept/Terms |
Ferrochelatase- Ferrochelatase
- Protoheme Ferro-Lyase
- Ferro-Lyase, Protoheme
- Protoheme Ferro Lyase
- Heme Synthetase
- Synthetase, Heme
- Porphyrin-Metal Chelatase
- Chelatase, Porphyrin-Metal
- Porphyrin Metal Chelatase
|
Below are MeSH descriptors whose meaning is more general than "Ferrochelatase".
Below are MeSH descriptors whose meaning is more specific than "Ferrochelatase".
This graph shows the total number of publications written about "Ferrochelatase" by people in this website by year, and whether "Ferrochelatase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ferrochelatase" by people in Profiles.
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Admixture mapping identifies novel loci for obstructive sleep apnea in Hispanic/Latino Americans. Hum Mol Genet. 2019 02 15; 28(4):675-687.
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Identification and characterization of haemofungin, a novel antifungal compound that inhibits the final step of haem biosynthesis. J Antimicrob Chemother. 2016 Apr; 71(4):946-52.
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Interdomain lateral gene transfer of an essential ferrochelatase gene in human parasitic nematodes. Proc Natl Acad Sci U S A. 2013 May 07; 110(19):7748-53.
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Identification of histidine-60 interaction with copper in activation of Chironomidae ferrochelatase. Protein Pept Lett. 2006; 13(5):443-6.
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Cloning and characterization of chironomidae ferrochelatase: copper activation of the purified ferrochelatase. Mol Cell Biochem. 2004 Jul; 262(1-2):225-31.