"DNA Polymerase gamma" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA-directed DNA polymerase that functions in the replication of MITOCHONDRIAL DNA. Mutations in the gene that encodes this enzyme (POLG) are associated with some forms of OPHTHALMOPLEGIA, CHRONIC EXTERNAL PROGRESSIVE.
| Descriptor ID |
D000074002
|
| MeSH Number(s) |
D08.811.913.696.445.308.300.169 D12.776.575.280
|
| Concept/Terms |
DNA Polymerase gamma- DNA Polymerase gamma
- Polymerase gamma, DNA
- Mitochondrial DNA Polymerase
- DNA Polymerase, Mitochondrial
- Polymerase, Mitochondrial DNA
|
Below are MeSH descriptors whose meaning is more general than "DNA Polymerase gamma".
Below are MeSH descriptors whose meaning is more specific than "DNA Polymerase gamma".
This graph shows the total number of publications written about "DNA Polymerase gamma" by people in this website by year, and whether "DNA Polymerase gamma" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 2 | 2 |
| 2017 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "DNA Polymerase gamma" by people in Profiles.
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Pol? coordinates DNA synthesis and proofreading to ensure mitochondrial genome integrity. Nat Struct Mol Biol. 2023 06; 30(6):812-823.
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Poly(ADP-ribose) polymerase 1 regulates mitochondrial DNA repair in an NAD-dependent manner. J Biol Chem. 2021 Jan-Jun; 296:100309.
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Oxidative damage diminishes mitochondrial DNA polymerase replication fidelity. Nucleic Acids Res. 2020 01 24; 48(2):817-829.
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Whole-exome sequencing as a powerful tool for identifying genetic causes in a patient with POLG-related disorders and phenylketonuria. J Int Med Res. 2019 Mar; 47(3):1387-1394.
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Speech and swallowing abnormalities in adults with POLG associated ataxia (POLG-A). Mitochondrion. 2017 11; 37:1-7.
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Mitochondrial syndromes with leukoencephalopathies. Semin Neurol. 2012 Feb; 32(1):55-61.
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POLG mutation in a patient with cataracts, early-onset distal muscle weakness and atrophy, ovarian dysgenesis and 3-methylglutaconic aciduria. Gene. 2012 May 10; 499(1):209-12.
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Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat Genet. 2012 Jan 22; 44(3):260-8.
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POLG-related disorders: defects of the nuclear and mitochondrial genome interaction. Neurology. 2011 Nov 15; 77(20):1847-52.
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Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)-like phenotype: an expanded clinical spectrum of POLG1 mutations. J Neurol. 2012 May; 259(5):862-8.