"DNA Polymerase I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA-dependent DNA polymerase characterized in prokaryotes and may be present in higher organisms. It has both 3'-5' and 5'-3' exonuclease activity, but cannot use native double-stranded DNA as template-primer. It is not inhibited by sulfhydryl reagents and is active in both DNA synthesis and repair. EC 2.7.7.7.
Descriptor ID |
D004256
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MeSH Number(s) |
D08.811.913.696.445.308.300.225
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Concept/Terms |
DNA Polymerase I- DNA Polymerase I
- Polymerase I, DNA
- Klenow Fragment
- DNA-Dependent DNA Polymerase I
- DNA Dependent DNA Polymerase I
- DNA Pol I
- DNA Polymerase alpha
- Polymerase alpha, DNA
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Below are MeSH descriptors whose meaning is more general than "DNA Polymerase I".
Below are MeSH descriptors whose meaning is more specific than "DNA Polymerase I".
This graph shows the total number of publications written about "DNA Polymerase I" by people in this website by year, and whether "DNA Polymerase I" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1994 | 1 | 0 | 1 |
1995 | 0 | 1 | 1 |
1996 | 0 | 2 | 2 |
1997 | 1 | 0 | 1 |
1998 | 0 | 1 | 1 |
2000 | 0 | 1 | 1 |
2001 | 1 | 0 | 1 |
2002 | 0 | 1 | 1 |
2003 | 2 | 0 | 2 |
2004 | 0 | 1 | 1 |
2005 | 1 | 0 | 1 |
2006 | 1 | 0 | 1 |
2010 | 0 | 1 | 1 |
2011 | 0 | 1 | 1 |
2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA Polymerase I" by people in Profiles.
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RNase HIII Is Important for Okazaki Fragment Processing in Bacillus subtilis. J Bacteriol. 2019 04 01; 201(7).
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Comparative Molecular Dynamics Studies of Human DNA Polymerase ?. J Chem Inf Model. 2015 Dec 28; 55(12):2672-81.
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In situ ligation: a decade and a half of experience. Methods Mol Biol. 2011; 682:49-63.
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Competition of Escherichia coli DNA polymerases I, II and III with DNA Pol IV in stressed cells. PLoS One. 2010 May 27; 5(5):e10862.
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Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol. J Biol Chem. 2006 Aug 18; 281(33):23445-55.
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The evolutionary origin of a complex scrambled gene. Proc Natl Acad Sci U S A. 2005 Oct 18; 102(42):15149-54.
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Adaptive amplification and point mutation are independent mechanisms: evidence for various stress-inducible mutation mechanisms. PLoS Biol. 2004 Dec; 2(12):e399.
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POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308. J Biol Chem. 2003 Aug 22; 278(34):32014-9.
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Effects of 8-chlorodeoxyadenosine on DNA synthesis by the Klenow fragment of DNA polymerase I. Bioorg Med Chem Lett. 2003 May 05; 13(9):1509-12.
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Action of (E)-2'-deoxy-2'-(fluoromethylene)cytidine on DNA metabolism: incorporation, excision, and cellular response. Mol Pharmacol. 2002 Jan; 61(1):222-9.