"DNA Polymerase II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms. It may be present in higher organisms and has an intrinsic molecular activity only 5% of that of DNA Polymerase I. This polymerase has 3'-5' exonuclease activity, is effective only on duplex DNA with gaps or single-strand ends of less than 100 nucleotides as template, and is inhibited by sulfhydryl reagents. EC 2.7.7.7.
| Descriptor ID |
D004257
|
| MeSH Number(s) |
D08.811.913.696.445.308.300.230
|
| Concept/Terms |
DNA Polymerase II- DNA Polymerase II
- DNA Polymerase epsilon
- DNA-Dependent DNA Polymerase II
- DNA Dependent DNA Polymerase II
- DNA Pol II
|
Below are MeSH descriptors whose meaning is more general than "DNA Polymerase II".
Below are MeSH descriptors whose meaning is more specific than "DNA Polymerase II".
This graph shows the total number of publications written about "DNA Polymerase II" by people in this website by year, and whether "DNA Polymerase II" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2010 | 1 | 1 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "DNA Polymerase II" by people in Profiles.
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Germline POLE mutation in a child with hypermutated medulloblastoma and features of constitutional mismatch repair deficiency. Cold Spring Harb Mol Case Stud. 2019 10; 5(5).
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Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas. Cancer Cell. 2018 04 09; 33(4):721-735.e8.
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Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis. Neuro Oncol. 2015 Oct; 17(10):1356-64.
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Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication. Genome Res. 2014 Nov; 24(11):1740-50.
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Integrated genomic characterization of endometrial carcinoma. Nature. 2013 May 02; 497(7447):67-73.
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Separate DNA Pol II- and Pol IV-dependent pathways of stress-induced mutation during double-strand-break repair in Escherichia coli are controlled by RpoS. J Bacteriol. 2010 Sep; 192(18):4694-700.
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Competition of Escherichia coli DNA polymerases I, II and III with DNA Pol IV in stressed cells. PLoS One. 2010 May 27; 5(5):e10862.
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Effects of base excision repair gene polymorphisms on pancreatic cancer survival. Int J Cancer. 2007 Apr 15; 120(8):1748-54.
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Characterization of a second proliferating cell nuclear antigen (PCNA2) from Drosophila melanogaster. FEBS J. 2006 Nov; 273(22):5062-73.
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Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly. J Biol Chem. 2006 Jun 02; 281(22):15172-81.