DNA Breaks, Double-Stranded
"DNA Breaks, Double-Stranded" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Interruptions in the sugar-phosphate backbone of DNA, across both strands adjacently.
| Descriptor ID |
D053903
|
| MeSH Number(s) |
G05.200.210.220
|
| Concept/Terms |
DNA Breaks, Double-Stranded- DNA Breaks, Double-Stranded
- Break, Double-Stranded DNA
- Breaks, Double-Stranded DNA
- DNA Break, Double-Stranded
- DNA Breaks, Double Stranded
- Double-Stranded DNA Break
- Double Stranded DNA Break
- Double-Strand DNA Breaks
- Break, Double-Strand DNA
- Breaks, Double-Strand DNA
- DNA Break, Double-Strand
- DNA Breaks, Double-Strand
- Double Strand DNA Breaks
- Double-Strand DNA Break
- Double-Stranded DNA Breaks
- Double Stranded DNA Breaks
|
Below are MeSH descriptors whose meaning is more general than "DNA Breaks, Double-Stranded".
Below are MeSH descriptors whose meaning is more specific than "DNA Breaks, Double-Stranded".
This graph shows the total number of publications written about "DNA Breaks, Double-Stranded" by people in this website by year, and whether "DNA Breaks, Double-Stranded" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 1 | 2 |
| 2008 | 1 | 2 | 3 |
| 2009 | 0 | 3 | 3 |
| 2010 | 7 | 4 | 11 |
| 2011 | 4 | 3 | 7 |
| 2012 | 4 | 2 | 6 |
| 2013 | 2 | 2 | 4 |
| 2014 | 3 | 4 | 7 |
| 2015 | 4 | 1 | 5 |
| 2016 | 4 | 4 | 8 |
| 2017 | 2 | 6 | 8 |
| 2018 | 3 | 4 | 7 |
| 2019 | 2 | 4 | 6 |
| 2020 | 1 | 2 | 3 |
| 2021 | 3 | 3 | 6 |
| 2022 | 2 | 3 | 5 |
| 2023 | 1 | 2 | 3 |
| 2024 | 0 | 1 | 1 |
| 2025 | 1 | 2 | 3 |
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Below are the most recent publications written about "DNA Breaks, Double-Stranded" by people in Profiles.
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DNA double-stranded breaks, a hallmark of aging, defined at the nucleotide resolution, are increased and associated with transcription in the cardiac myocytes in LMNA-cardiomyopathy. Cardiovasc Res. 2025 Aug 28; 121(10):1582-1593.
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PARP inhibitor response is enhanced in prostate cancer when XRCC1 expression is reduced. NAR Cancer. 2025 Jun; 7(2):zcaf015.
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Endogenous DNA damage at sites of terminated transcripts. Nature. 2025 Apr; 640(8057):240-248.
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RPA and Rad27 limit templated and inverted insertions at DNA breaks. Nucleic Acids Res. 2025 Jan 07; 53(1).
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Direct and Indirect Effects for Radiosensitization of Gold Nanoparticles in Proton Therapy. Radiat Res. 2024 11 01; 202(5):795-806.
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Yeast EndoG prevents genome instability by degrading extranuclear DNA species. Nat Commun. 2024 09 03; 15(1):7653.
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Ubiquitin-induced RNF168 condensation promotes DNA double-strand break repair. Proc Natl Acad Sci U S A. 2024 Jul 09; 121(28):e2322972121.
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ATM inhibition exploits checkpoint defects and ATM-dependent double strand break repair in TP53-mutant glioblastoma. Nat Commun. 2024 Jun 21; 15(1):5294.
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REV7-p53 interaction inhibits ATM-mediated DNA damage signaling. Cell Cycle. 2024 Feb; 23(4):339-352.
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Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration. Cell. 2023 09 28; 186(20):4404-4421.e20.