"Chromosome Breakage" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A type of chromosomal aberration involving DNA BREAKS. Chromosome breakage can result in CHROMOSOMAL TRANSLOCATION; CHROMOSOME INVERSION; or SEQUENCE DELETION.
| Descriptor ID |
D019457
|
| MeSH Number(s) |
C23.550.210.170 G05.200.210.170 G05.365.590.175.175
|
| Concept/Terms |
Chromosome Breakage- Chromosome Breakage
- Breakage, Chromosome
- Breakages, Chromosome
- Chromosome Breakages
- Chromosomal Breakage
- Breakage, Chromosomal
- Breakages, Chromosomal
- Chromosomal Breakages
Chromosome Breaks- Chromosome Breaks
- Break, Chromosome
- Breaks, Chromosome
- Chromosome Break
- Chromosomal Breaks
- Break, Chromosomal
- Breaks, Chromosomal
- Chromosomal Break
|
Below are MeSH descriptors whose meaning is more general than "Chromosome Breakage".
Below are MeSH descriptors whose meaning is more specific than "Chromosome Breakage".
This graph shows the total number of publications written about "Chromosome Breakage" by people in this website by year, and whether "Chromosome Breakage" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 2 | 3 |
| 1997 | 0 | 1 | 1 |
| 1998 | 4 | 2 | 6 |
| 1999 | 1 | 0 | 1 |
| 2000 | 2 | 1 | 3 |
| 2001 | 3 | 3 | 6 |
| 2002 | 1 | 6 | 7 |
| 2003 | 6 | 6 | 12 |
| 2004 | 0 | 5 | 5 |
| 2005 | 3 | 5 | 8 |
| 2006 | 1 | 10 | 11 |
| 2007 | 1 | 3 | 4 |
| 2008 | 3 | 6 | 9 |
| 2009 | 2 | 6 | 8 |
| 2010 | 0 | 3 | 3 |
| 2011 | 0 | 5 | 5 |
| 2012 | 1 | 0 | 1 |
| 2013 | 4 | 1 | 5 |
| 2014 | 1 | 1 | 2 |
| 2016 | 1 | 2 | 3 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Chromosome Breakage" by people in Profiles.
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A familial deletion of 10p12.1 associated with thrombocytopenia. Am J Med Genet A. 2024 01; 194(1):77-81.
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Dna2 nuclease deficiency results in large and complex DNA insertions at chromosomal breaks. Nature. 2018 12; 564(7735):287-290.
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Expanding the FANCO/RAD51C associated phenotype: Cleft lip and palate and lobar holoprosencephaly, two rare findings in Fanconi anemia. Eur J Med Genet. 2018 May; 61(5):257-261.
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Whole-Genome Sequencing of Cytogenetically Balanced Chromosome Translocations Identifies Potentially Pathological Gene Disruptions and Highlights the Importance of Microhomology in the Mechanism of Formation. Hum Mutat. 2017 02; 38(2):180-192.
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Metformin improves defective hematopoiesis and delays tumor formation in Fanconi anemia mice. Blood. 2016 12 15; 128(24):2774-2784.
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Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease. J Clin Invest. 2016 08 01; 126(8):2881-92.
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Passage number is a major contributor to genomic structural variations in mouse iPSCs. Stem Cells. 2014 Oct; 32(10):2657-67.
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Loeys-Dietz syndrome type 4, caused by chromothripsis, involving the TGFB2 gene. Gene. 2014 Mar 15; 538(1):69-73.
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Molecular and phenotypic characterization of atypical Williams-Beuren syndrome. Clin Genet. 2014 Nov; 86(5):487-91.
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Intragenic breakpoint: a marker of genome instability in glioblastoma. Cell Cycle. 2013 Dec 15; 12(24):3705-6.