"Protein Deglycase DJ-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, releasing repaired proteins and lactate or glycolate. It deglycates CYSTEINE, ARGININE and LYSINE residues to reactivate proteins by reversing glycation and prevent the formation of ADVANCED GLYCATION END PRODUCTS. It protects cells against OXIDATIVE STRESS and CELL DEATH by functioning as an oxidative stress sensor and redox-sensitive MOLECULAR CHAPERONE and PROTEASE. Mutations in the PARK7 gene are associated with autosomal-recessive, early-onset PARKINSON DISEASE.
| Descriptor ID |
D000071617
|
| MeSH Number(s) |
D08.811.277.785 D12.776.637.875
|
| Concept/Terms |
Protein Deglycase DJ-1- Protein Deglycase DJ-1
- DJ-1, Protein Deglycase
- DJ-1-PARK7 Protein
- DJ 1 PARK7 Protein
- DJ-1 Protein
- DJ 1 Protein
- Parkinson Protein 7
- DJ1 Protein
- PARK7 Protein
- Parkinsonism Associated Deglycase
- Deglycase, Parkinsonism Associated
|
Below are MeSH descriptors whose meaning is more general than "Protein Deglycase DJ-1".
Below are MeSH descriptors whose meaning is more specific than "Protein Deglycase DJ-1".
This graph shows the total number of publications written about "Protein Deglycase DJ-1" by people in this website by year, and whether "Protein Deglycase DJ-1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protein Deglycase DJ-1" by people in Profiles.
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Parkinson's disease variant detection and disclosure: PD GENEration, a North American study. Brain. 2024 Aug 01; 147(8):2668-2679.
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GATD3A, a mitochondrial deglycase with evolutionary origins from gammaproteobacteria, restricts the formation of advanced glycation end products. BMC Biol. 2022 03 21; 20(1):68.
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Autophagy inhibition rescues structural and functional defects caused by the loss of mitochondrial chaperone Hsc70-5 in Drosophila. Autophagy. 2021 10; 17(10):3160-3174.
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Juvenile parkinsonism: Differential diagnosis, genetics, and treatment. Parkinsonism Relat Disord. 2019 10; 67:74-89.
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DJ-1 modulates the unfolded protein response and cell death via upregulation of ATF4 following ER stress. Cell Death Dis. 2019 02 12; 10(2):135.
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Unaltered striatal dopamine release levels in young Parkin knockout, Pink1 knockout, DJ-1 knockout and LRRK2 R1441G transgenic mice. PLoS One. 2014; 9(4):e94826.
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Minireview: nuclear receptor and coregulator proteomics--2012 and beyond. Mol Endocrinol. 2012 Oct; 26(10):1646-50.
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Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression. Ann Neurol. 2011 Mar; 69(3):570-80.
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Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease. Neurosci Lett. 2010 Aug 09; 480(1):78-82.
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DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease. Brain. 2010 Mar; 133(Pt 3):713-26.