Pyruvate Dehydrogenase Complex
"Pyruvate Dehydrogenase Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phosphorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
Descriptor ID |
D011768
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MeSH Number(s) |
D05.500.562.625 D08.811.600.741
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Pyruvate Dehydrogenase Complex".
Below are MeSH descriptors whose meaning is more specific than "Pyruvate Dehydrogenase Complex".
This graph shows the total number of publications written about "Pyruvate Dehydrogenase Complex" by people in this website by year, and whether "Pyruvate Dehydrogenase Complex" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1996 | 2 | 1 | 3 |
1998 | 0 | 1 | 1 |
2006 | 0 | 1 | 1 |
2013 | 1 | 0 | 1 |
2015 | 0 | 3 | 3 |
2016 | 2 | 1 | 3 |
2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Pyruvate Dehydrogenase Complex" by people in Profiles.
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Suppression of PDHX by microRNA-27b deregulates cell metabolism and promotes growth in breast cancer. Mol Cancer. 2018 07 16; 17(1):100.
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Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase. J Biol Chem. 2016 Nov 04; 291(45):23490-23505.
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Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis. Mol Cell. 2016 Mar 03; 61(5):705-719.
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Pyruvate Dehydrogenase Activity Is Decreased in Emergency Department Patients With Diabetic Ketoacidosis. Acad Emerg Med. 2016 06; 23(6):685-9.
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Acute Treatment of Resveratrol Alleviates Doxorubicin-Induced Myotoxicity in Aged Skeletal Muscle Through SIRT1-Dependent Mechanisms. J Gerontol A Biol Sci Med Sci. 2016 06; 71(6):730-9.
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Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress. PLoS Biol. 2015 Jul; 13(7):e1002197.
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Effects of long-term resveratrol-induced SIRT1 activation on insulin and apoptotic signalling in aged skeletal muscle. Acta Diabetol. 2015 Dec; 52(6):1063-75.
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HIV-1 Vpr enhances PPAR?/d-mediated transcription, increases PDK4 expression, and reduces PDC activity. Mol Endocrinol. 2013 Sep; 27(9):1564-76.
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Structures of the human pyruvate dehydrogenase complex cores: a highly conserved catalytic center with flexible N-terminal domains. Structure. 2008 Jan; 16(1):104-14.
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Proteomic analysis of mice hippocampus in simulated microgravity environment. J Proteome Res. 2006 Mar; 5(3):548-53.