Pyruvate Dehydrogenase Complex
"Pyruvate Dehydrogenase Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
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A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phosphorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
| Descriptor ID |
D011768
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| MeSH Number(s) |
D05.500.562.625 D08.811.600.741
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Pyruvate Dehydrogenase Complex".
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This graph shows the total number of publications written about "Pyruvate Dehydrogenase Complex" by people in this website by year, and whether "Pyruvate Dehydrogenase Complex" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 1 | 2 |
| 1998 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 2 | 0 | 2 |
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Below are the most recent publications written about "Pyruvate Dehydrogenase Complex" by people in Profiles.
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Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase. J Biol Chem. 2016 Nov 04; 291(45):23490-23505.
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Pyruvate Dehydrogenase Activity Is Decreased in Emergency Department Patients With Diabetic Ketoacidosis. Acad Emerg Med. 2016 06; 23(6):685-9.
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Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress. PLoS Biol. 2015 Jul; 13(7):e1002197.
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HIV-1 Vpr enhances PPAR?/d-mediated transcription, increases PDK4 expression, and reduces PDC activity. Mol Endocrinol. 2013 Sep; 27(9):1564-76.
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Proteomic analysis of mice hippocampus in simulated microgravity environment. J Proteome Res. 2006 Mar; 5(3):548-53.
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Gluconeogenesis measured with [U-13C]glucose and mass isotopomer analysis of apoB-100 amino acids in pigs. Am J Physiol. 1998 02; 274(2):E365-76.
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Pyruvate dehydrogenase inactivity is not responsible for sepsis-induced insulin resistance. Crit Care Med. 1996 Apr; 24(4):566-74.
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Leigh disease with deficiency of lipoamide dehydrogenase: treatment failure with dichloroacetate. Pediatr Neurol. 1996 Jan; 14(1):69-71.
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Isotopic evaluation of the metabolism of pyruvate and related substrates in normal adult volunteers and severely burned children: effect of dichloroacetate and glucose infusion. Surgery. 1991 Jul; 110(1):54-67.