Proteasome Endopeptidase Complex
"Proteasome Endopeptidase Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.
Descriptor ID |
D046988
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MeSH Number(s) |
D05.500.562.500 D08.811.277.656.918 D08.811.600.730
|
Concept/Terms |
Proteasome Endopeptidase Complex- Proteasome Endopeptidase Complex
- Complex, Proteasome Endopeptidase
- Endopeptidase Complex, Proteasome
- Macropain
- Macroxyproteinase
- Multicatalytic Proteinase
- Proteinase, Multicatalytic
- Prosome
- Proteasome
- 20S Proteasome
- Proteasome, 20S
- Multicatalytic Endopeptidase Complex
- Complex, Multicatalytic Endopeptidase
- Endopeptidase Complex, Multicatalytic
|
Below are MeSH descriptors whose meaning is more general than "Proteasome Endopeptidase Complex".
Below are MeSH descriptors whose meaning is more specific than "Proteasome Endopeptidase Complex".
This graph shows the total number of publications written about "Proteasome Endopeptidase Complex" by people in this website by year, and whether "Proteasome Endopeptidase Complex" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 0 | 1 | 1 |
1995 | 0 | 3 | 3 |
1996 | 0 | 1 | 1 |
1997 | 0 | 3 | 3 |
1998 | 1 | 4 | 5 |
1999 | 0 | 10 | 10 |
2000 | 1 | 1 | 2 |
2001 | 0 | 6 | 6 |
2002 | 1 | 15 | 16 |
2003 | 4 | 14 | 18 |
2004 | 4 | 22 | 26 |
2005 | 10 | 17 | 27 |
2006 | 10 | 15 | 25 |
2007 | 7 | 20 | 27 |
2008 | 3 | 14 | 17 |
2009 | 10 | 19 | 29 |
2010 | 11 | 14 | 25 |
2011 | 2 | 14 | 16 |
2012 | 3 | 12 | 15 |
2013 | 12 | 6 | 18 |
2014 | 5 | 8 | 13 |
2015 | 8 | 2 | 10 |
2016 | 5 | 7 | 12 |
2017 | 5 | 4 | 9 |
2018 | 1 | 5 | 6 |
2019 | 4 | 6 | 10 |
2020 | 5 | 4 | 9 |
2021 | 5 | 4 | 9 |
2022 | 4 | 2 | 6 |
2023 | 0 | 1 | 1 |
2024 | 1 | 1 | 2 |
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Below are the most recent publications written about "Proteasome Endopeptidase Complex" by people in Profiles.
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Proteasome inhibition for glioblastoma: Lessons learned and new opportunities. Neuro Oncol. 2024 Sep 05; 26(9):1683-1684.
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PSMD11 loss-of-function variants correlate with a neurobehavioral phenotype, obesity, and increased interferon response. Am J Hum Genet. 2024 07 11; 111(7):1352-1369.
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Ubiquitin-proteasome system regulation of a key gene regulatory factor, Paf1C. Gene. 2024 Feb 05; 894:148004.
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A novel ubiquitin-proteasome system regulation of Sgf73/ataxin-7 that maintains the integrity of the coactivator SAGA in orchestrating transcription. Genetics. 2023 07 06; 224(3).
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Proteasome inhibition in combination with immunotherapies: State-of-the-Art in multiple myeloma. Blood Rev. 2023 09; 61:101100.
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Proteasome Inhibitors Silence Oncogenes in Multiple Myeloma through Localized Histone Deacetylase 3 (HDAC3) Stabilization and Chromatin Condensation. Cancer Res Commun. 2022 12; 2(12):1693-1710.
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The role of E3 ubiquitin ligase in multiple myeloma: potential for cereblon E3 ligase modulators in the treatment of relapsed/refractory disease. Expert Rev Proteomics. 2022 Apr-Jun; 19(4-6):235-246.
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Aging-associated REG? proteasome decline predisposes to tauopathy. J Biol Chem. 2022 11; 298(11):102571.
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Targeted Protein Degradation via Lysosomes. Biochemistry. 2023 02 07; 62(3):564-579.
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Nucleoporins are degraded via upregulation of ESCRT-III/Vps4 complex in Drosophila models of C9-ALS/FTD. Cell Rep. 2022 09 20; 40(12):111379.