Proteasome Endopeptidase Complex
"Proteasome Endopeptidase Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.
| Descriptor ID |
D046988
|
| MeSH Number(s) |
D05.500.562.500 D08.811.277.656.918 D08.811.600.730
|
| Concept/Terms |
Proteasome Endopeptidase Complex- Proteasome Endopeptidase Complex
- Complex, Proteasome Endopeptidase
- Endopeptidase Complex, Proteasome
- Macropain
- Macroxyproteinase
- Multicatalytic Proteinase
- Proteinase, Multicatalytic
- Prosome
- Proteasome
- 20S Proteasome
- Proteasome, 20S
- Multicatalytic Endopeptidase Complex
- Complex, Multicatalytic Endopeptidase
- Endopeptidase Complex, Multicatalytic
|
Below are MeSH descriptors whose meaning is more general than "Proteasome Endopeptidase Complex".
Below are MeSH descriptors whose meaning is more specific than "Proteasome Endopeptidase Complex".
This graph shows the total number of publications written about "Proteasome Endopeptidase Complex" by people in this website by year, and whether "Proteasome Endopeptidase Complex" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 6 | 6 |
| 2000 | 1 | 1 | 2 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 4 | 4 |
| 2003 | 1 | 4 | 5 |
| 2004 | 1 | 8 | 9 |
| 2005 | 5 | 6 | 11 |
| 2006 | 5 | 5 | 10 |
| 2007 | 3 | 8 | 11 |
| 2008 | 1 | 7 | 8 |
| 2009 | 6 | 6 | 12 |
| 2010 | 7 | 6 | 13 |
| 2011 | 2 | 6 | 8 |
| 2012 | 1 | 6 | 7 |
| 2013 | 7 | 5 | 12 |
| 2014 | 1 | 4 | 5 |
| 2015 | 2 | 0 | 2 |
| 2016 | 3 | 4 | 7 |
| 2017 | 3 | 3 | 6 |
| 2018 | 0 | 3 | 3 |
| 2019 | 2 | 4 | 6 |
| 2020 | 2 | 3 | 5 |
| 2021 | 2 | 2 | 4 |
| 2022 | 1 | 3 | 4 |
| 2024 | 1 | 0 | 1 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Proteasome Endopeptidase Complex" by people in Profiles.
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MYC-Targeting PROTACs Lead to Bimodal Degradation and N-Terminal Truncation. ACS Chem Biol. 2025 Apr 18; 20(4):896-906.
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PSMD11 loss-of-function variants correlate with a neurobehavioral phenotype, obesity, and increased interferon response. Am J Hum Genet. 2024 07 11; 111(7):1352-1369.
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Proteasome Inhibitors Silence Oncogenes in Multiple Myeloma through Localized Histone Deacetylase 3 (HDAC3) Stabilization and Chromatin Condensation. Cancer Res Commun. 2022 12; 2(12):1693-1710.
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Nucleoporins are degraded via upregulation of ESCRT-III/Vps4 complex in Drosophila models of C9-ALS/FTD. Cell Rep. 2022 09 20; 40(12):111379.
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Identification of PSMB5 as a genetic modifier of fragile X-associated tremor/ataxia syndrome. Proc Natl Acad Sci U S A. 2022 05 31; 119(22):e2118124119.
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Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy. Cancer Res. 2022 04 01; 82(7):1234-1250.
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A model of the aged lung epithelium in idiopathic pulmonary fibrosis. Aging (Albany NY). 2021 07 08; 13(13):16922-16937.
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Modulation of proteasome activity by curcumin and didemethylcurcumin. J Biomol Struct Dyn. 2022 11; 40(18):8332-8339.
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Cycad Genotoxin Methylazoxymethanol Disrupts the Brain Ubiquitin-Proteasome Pathway, Tau and a-Synuclein, as Reported in ALS-PDC. J Neuropathol Exp Neurol. 2021 02 22; 80(3):286-288.
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Dihydroquinazolines enhance 20S proteasome activity and induce degradation of a-synuclein, an intrinsically disordered protein associated with neurodegeneration. Bioorg Med Chem Lett. 2021 03 15; 36:127821.