"Proprotein Convertases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Proteolytic enzymes that are involved in the conversion of protein precursors such as peptide prohormones into PEPTIDE HORMONES. Some are ENDOPEPTIDASES, some are EXOPEPTIDASES.
| Descriptor ID |
D043484
|
| MeSH Number(s) |
D08.811.277.656.837
|
| Concept/Terms |
Proprotein Convertases- Proprotein Convertases
- Convertases, Proprotein
- Proprotein Convertase
- Convertase, Proprotein
Prohormone Convertases- Prohormone Convertases
- Convertases, Prohormone
- Prohormone Convertase
- Convertase, Prohormone
Subtilisin-Like Proprotein Convertases- Subtilisin-Like Proprotein Convertases
- Convertases, Subtilisin-Like Proprotein
- Proprotein Convertases, Subtilisin-Like
- Subtilisin Like Proprotein Convertases
Pro-Opiomelanocortin Converting Enzyme- Pro-Opiomelanocortin Converting Enzyme
- Converting Enzyme, Pro-Opiomelanocortin
- Pro Opiomelanocortin Converting Enzyme
- POMC Enzyme
- POMC-Converting Enzyme
- POMC Converting Enzyme
- Pro-Opiocortin Converting Protease
- Converting Protease, Pro-Opiocortin
- Pro Opiocortin Converting Protease
- Proopiomelanocortin Convertase
- Convertase, Proopiomelanocortin
- POMC Convertase
- Convertase, POMC
- Pro-Opiocortin Converting Enzyme
- Converting Enzyme, Pro-Opiocortin
- Pro Opiocortin Converting Enzyme
|
Below are MeSH descriptors whose meaning is more general than "Proprotein Convertases".
Below are MeSH descriptors whose meaning is more specific than "Proprotein Convertases".
This graph shows the total number of publications written about "Proprotein Convertases" by people in this website by year, and whether "Proprotein Convertases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 2 | 3 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 3 | 3 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 2 | 1 | 3 |
| 2014 | 2 | 1 | 3 |
| 2015 | 2 | 0 | 2 |
| 2023 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Proprotein Convertases" by people in Profiles.
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Dominant missense variants in SREBF2 are associated with complex dermatological, neurological, and skeletal abnormalities. Genet Med. 2024 Sep; 26(9):101174.
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Phase 2b Randomized Trial of the Oral PCSK9 Inhibitor MK-0616. J Am Coll Cardiol. 2023 04 25; 81(16):1553-1564.
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The promise of proprotein convertase subtilisin/kexin 9 inhibitors for the treatment of familial hypercholesterolemia. Curr Atheroscler Rep. 2015 May; 17(5):508.
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Genetics of familial hypercholesterolemia. Curr Atheroscler Rep. 2015 Apr; 17(4):491.
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Results of bococizumab, a monoclonal antibody against proprotein convertase subtilisin/kexin type 9, from a randomized, placebo-controlled, dose-ranging study in statin-treated subjects with hypercholesterolemia. Am J Cardiol. 2015 May 01; 115(9):1212-21.
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Lipid lowering with PCSK9 inhibitors. Nat Rev Cardiol. 2014 Oct; 11(10):563-75.
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A 52-week placebo-controlled trial of evolocumab in hyperlipidemia. N Engl J Med. 2014 May 08; 370(19):1809-19.
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Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. Am J Hum Genet. 2014 Feb 06; 94(2):233-45.
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FoxO3 transcription factor and Sirt6 deacetylase regulate low density lipoprotein (LDL)-cholesterol homeostasis via control of the proprotein convertase subtilisin/kexin type 9 (Pcsk9) gene expression. J Biol Chem. 2013 Oct 11; 288(41):29252-9.
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Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained. PLoS Genet. 2013 Mar; 9(3):e1003379.