"Quinone Reductases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
NAD(P)H:(quinone acceptor) oxidoreductases. A family that includes three enzymes which are distinguished by their sensitivity to various inhibitors. EC 1.6.99.2 (NAD(P)H DEHYDROGENASE (QUINONE);) is a flavoprotein which reduces various quinones in the presence of NADH or NADPH and is inhibited by dicoumarol. EC 1.6.99.5 (NADH dehydrogenase (quinone)) requires NADH, is inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivatives. EC 1.6.99.6 (NADPH dehydrogenase (quinone)) requires NADPH and is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol.
| Descriptor ID |
D011808
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| MeSH Number(s) |
D08.811.682.608.800
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Quinone Reductases".
Below are MeSH descriptors whose meaning is more specific than "Quinone Reductases".
This graph shows the total number of publications written about "Quinone Reductases" by people in this website by year, and whether "Quinone Reductases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
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Below are the most recent publications written about "Quinone Reductases" by people in Profiles.
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Association of NRH:quinone oxidoreductase 2 gene promoter polymorphism with higher gene expression and increased susceptibility to Parkinson's disease. J Gerontol A Biol Sci Med Sci. 2008 Feb; 63(2):127-34.
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NQO1 and NQO2 regulation of humoral immunity and autoimmunity. J Biol Chem. 2006 Oct 13; 281(41):30917-24.
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BALT development and augmentation of hyperoxic lung injury in mice deficient in NQO1 and NQO2. Free Radic Biol Med. 2006 May 15; 40(10):1843-56.
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Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity. J Biol Chem. 2002 Nov 29; 277(48):46131-9.
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Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy. Br J Cancer. 1997; 76(7):852-4.
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Murine mdr-1, mdr-2, and mdr-3 gene expression: no coinduction with the Cyp1a-1 and Nmo-1 genes in liver by 2,3,7,8-tetrachlorodibenzo-p-dioxin. DNA Cell Biol. 1991 Jul-Aug; 10(6):433-41.
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Rapid, quantitative microassay for the monokine respiration inhibitory factor. J Immunol Methods. 1987 Jul 16; 101(1):97-108.