"Spectrin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A high molecular weight (220-250 kDa) water-soluble protein which can be extracted from erythrocyte ghosts in low ionic strength buffers. The protein contains no lipids or carbohydrates, is the predominant species of peripheral erythrocyte membrane proteins, and exists as a fibrous coating on the inner, cytoplasmic surface of the membrane.
| Descriptor ID |
D013049
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| MeSH Number(s) |
D12.776.220.980 D12.776.543.850
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Spectrin".
Below are MeSH descriptors whose meaning is more specific than "Spectrin".
This graph shows the total number of publications written about "Spectrin" by people in this website by year, and whether "Spectrin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2004 | 2 | 0 | 2 |
| 2006 | 1 | 0 | 1 |
| 2007 | 3 | 1 | 4 |
| 2008 | 1 | 1 | 2 |
| 2009 | 2 | 0 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 1 | 2 |
| 2012 | 0 | 2 | 2 |
| 2013 | 1 | 1 | 2 |
| 2014 | 2 | 0 | 2 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 2 | 3 |
| 2017 | 2 | 0 | 2 |
| 2018 | 5 | 0 | 5 |
| 2019 | 2 | 0 | 2 |
| 2020 | 2 | 1 | 3 |
| 2021 | 3 | 1 | 4 |
| 2022 | 1 | 1 | 2 |
| 2023 | 3 | 0 | 3 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Spectrin" by people in Profiles.
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Detection of alpha II-spectrin breakdown products in the serum of neonates with congenital heart disease*. Pediatr Crit Care Med. 2014 Mar; 15(3):229-35.
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Novel 9q34.11 gene deletions encompassing combinations of four Mendelian disease genes: STXBP1, SPTAN1, ENG, and TOR1A. Genet Med. 2012 Oct; 14(10):868-76.
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Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting. Nature. 2012 Feb 08; 482(7385):400-4.
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Loss of transforming growth factor ? adaptor protein ?-2 spectrin leads to delayed liver regeneration in mice. Hepatology. 2011 May; 53(5):1641-50.
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Disruption of transforming growth factor-beta signaling through beta-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation. Oncogene. 2007 Nov 01; 26(50):7103-10.
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Critical interactions between TGF-beta signaling/ELF, and E-cadherin/beta-catenin mediated tumor suppression. Oncogene. 2006 Mar 23; 25(13):1871-86.
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Headpiece domain of dematin is required for the stability of the erythrocyte membrane. Proc Natl Acad Sci U S A. 2002 May 14; 99(10):6637-42.
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Temporospatial sequence of cellular events associated with etoposide-induced neuronal cell death: role of antiapoptotic protein Bcl-X(L). J Neurosci Res. 2001 Dec 15; 66(6):1074-82.
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Purification and biochemical characterization of a protein-palmitoyl acyltransferase from human erythrocytes. J Biol Chem. 1997 Apr 25; 272(17):11021-5.
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Mutually exclusive distribution of the focal adhesion associated proteins and the erythrocyte membrane skeleton proteins in the human fibroblast plasma membrane undercoat. Cell Struct Funct. 1996 Feb; 21(1):27-39.