"Plakophilins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Members of the armadillo family of proteins that are found in DESMOSOMES and interact with various proteins including desmocadherins; DESMOPLAKIN; ACTIN FILAMENTS; and KERATINS.
| Descriptor ID |
D051191
|
| MeSH Number(s) |
D12.776.091.750 D12.776.220.885
|
| Concept/Terms |
Plakophilin 1- Plakophilin 1
- Band 6 Protein, Desmosomal
- Desmosome Band 6 Polypeptide
- Desmosome Band 6 Protein
|
Below are MeSH descriptors whose meaning is more general than "Plakophilins".
Below are MeSH descriptors whose meaning is more specific than "Plakophilins".
This graph shows the total number of publications written about "Plakophilins" by people in this website by year, and whether "Plakophilins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2012 | 2 | 0 | 2 |
| 2014 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Plakophilins" by people in Profiles.
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Plakophilin 1 in carcinogenesis. Mol Carcinog. 2024 Oct; 63(10):1855-1865.
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A catenin of the plakophilin-subfamily, Pkp3, responds to canonical-Wnt pathway components and signals. Biochem Biophys Res Commun. 2021 07 23; 563:31-39.
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Knock Down of Plakophillin 2 Dysregulates Adhesion Pathway through Upregulation of miR200b and Alters the Mechanical Properties in Cardiac Cells. Cells. 2019 12 14; 8(12).
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Incidentally identified genetic variants in arrhythmogenic right ventricular cardiomyopathy-associated genes among children undergoing exome sequencing reflect healthy population variation. Mol Genet Genomic Med. 2019 06; 7(6):e593.
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Plakophilin3 increases desmosome assembly, size and stability by increasing expression of desmocollin2. Biochem Biophys Res Commun. 2018 01 01; 495(1):768-774.
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Identification of established arrhythmogenic right ventricular cardiomyopathy mutation in a patient with the contrasting phenotype of hypertrophic cardiomyopathy. BMC Med Genet. 2017 Mar 03; 18(1):24.
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Knockdown of Plakophilin 2 Downregulates miR-184 Through CpG Hypermethylation and Suppression of the E2F1 Pathway and Leads to Enhanced Adipogenesis In Vitro. Circ Res. 2016 Sep 02; 119(6):731-50.
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Plakophilin-3 catenin associates with the ETV1/ER81 transcription factor to positively modulate gene activity. PLoS One. 2014; 9(1):e86784.
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Plakophilin3 loss leads to an increase in PRL3 levels promoting K8 dephosphorylation, which is required for transformation and metastasis. PLoS One. 2012; 7(6):e38561.
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Plakophilin-3 is required for late embryonic amphibian development, exhibiting roles in ectodermal and neural tissues. PLoS One. 2012; 7(4):e34342.