"Perforin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell.
| Descriptor ID |
D054353
|
| MeSH Number(s) |
D12.776.543.695.875
|
| Concept/Terms |
Perforin- Perforin
- Lymphocyte Pore-Forming Protein
- Lymphocyte Pore Forming Protein
- Pore-Forming Protein, Lymphocyte
- Perforin 1
- Cytolysin
|
Below are MeSH descriptors whose meaning is more general than "Perforin".
Below are MeSH descriptors whose meaning is more specific than "Perforin".
This graph shows the total number of publications written about "Perforin" by people in this website by year, and whether "Perforin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 4 | 4 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 2 | 2 |
| 2015 | 1 | 1 | 2 |
| 2017 | 0 | 2 | 2 |
| 2020 | 0 | 1 | 1 |
| 2021 | 2 | 1 | 3 |
| 2022 | 0 | 2 | 2 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Perforin" by people in Profiles.
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Harnessing the Power of CAR-NK Cells: A Promising Off-the-Shelf Therapeutic Strategy for CD38-Positive Malignancies. Iran J Immunol. 2023 12 31; 20(4):410-426.
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Vaccine-linked chemotherapy with a low dose of benznidazole plus a bivalent recombinant protein vaccine prevents the development of cardiac fibrosis caused by Trypanosoma cruzi in chronically-infected BALB/c mice. PLoS Negl Trop Dis. 2022 09; 16(9):e0010258.
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T cell-mediated additive cytotoxicity - death by multiple bullets. Trends Cancer. 2022 12; 8(12):980-987.
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Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity. Nat Commun. 2021 09 01; 12(1):5217.
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Post-transplantation donor-derived Sezary syndrome in a patient with A91V PRF1 variant hemophagocytic lymphohistiocytosis. Am J Hematol. 2021 09 01; 96(9):E350-E353.
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Haemophagocytic lymphohistiocytosis and Epstein-Barr virus: a complex relationship with diverse origins, expression and outcomes. Br J Haematol. 2022 01; 196(1):31-44.
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JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation. Blood. 2020 08 06; 136(6):657-668.
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Effects of transportation, relocation, and acclimation on phenotypes and functional characteristics of peripheral blood lymphocytes in rhesus monkeys (Macaca mulatta). PLoS One. 2017; 12(12):e0188694.
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Recycling endosomes in human cytotoxic T lymphocytes constitute an auxiliary intracellular trafficking pathway for newly synthesized perforin. Immunol Res. 2017 10; 65(5):1031-1045.
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Phenotypic and Functional Characterization of Peripheral Blood Lymphocytes from Various Age- and Sex-Specific Groups of Owl Monkeys (Aotus nancymaae). Comp Med. 2017 02 01; 67(1):67-78.