Pore Forming Cytotoxic Proteins
"Pore Forming Cytotoxic Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Proteins secreted from an organism which form membrane-spanning pores in target cells to destroy them. This is in contrast to PORINS and MEMBRANE TRANSPORT PROTEINS that function within the synthesizing organism and COMPLEMENT immune proteins. These pore forming cytotoxic proteins are a form of primitive cellular defense which are also found in human LYMPHOCYTES.
| Descriptor ID |
D052899
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| MeSH Number(s) |
D12.776.543.695
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Pore Forming Cytotoxic Proteins".
Below are MeSH descriptors whose meaning is more specific than "Pore Forming Cytotoxic Proteins".
This graph shows the total number of publications written about "Pore Forming Cytotoxic Proteins" by people in this website by year, and whether "Pore Forming Cytotoxic Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 3 | 3 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Pore Forming Cytotoxic Proteins" by people in Profiles.
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GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis. Cell. 2022 01 20; 185(2):283-298.e17.
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Paneth cells promote angiogenesis and regulate portal hypertension?in response to microbial signals. J Hepatol. 2020 09; 73(3):628-639.
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fHLH: becoming a blended family. Blood. 2014 Aug 21; 124(8):1210-1.
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Antigen-specific clonal expansion and cytolytic effector function of CD8+ T lymphocytes depend on the transcription factor Bcl11b. J Exp Med. 2010 Aug 02; 207(8):1687-99.
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Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control. PLoS Pathog. 2010 May 27; 6(5):e1000917.
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Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells. PLoS Pathog. 2010 Mar 05; 6(3):e1000798.
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CD8+ T cells require perforin to clear West Nile virus from infected neurons. J Virol. 2006 Jan; 80(1):119-29.
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Targeting heat shock proteins for immunotherapy in multiple myeloma: generation of myeloma-specific CTLs using dendritic cells pulsed with tumor-derived gp96. Clin Cancer Res. 2005 Dec 15; 11(24 Pt 1):8808-15.
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Differential regulation of granzyme and perforin in effector and memory T cells following smallpox immunization. J Immunol. 2005 Mar 15; 174(6):3757-64.
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Expression of CD1d by myelomonocytic leukemias provides a target for cytotoxic NKT cells. Leukemia. 2003 Jun; 17(6):1068-77.