Histiocytosis, Langerhans-Cell
"Histiocytosis, Langerhans-Cell" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of disorders resulting from the abnormal proliferation of and tissue infiltration by LANGERHANS CELLS which can be detected by their characteristic Birbeck granules (X bodies), or by monoclonal antibody staining for their surface CD1 ANTIGENS. Langerhans-cell granulomatosis can involve a single organ, or can be a systemic disorder.
| Descriptor ID |
D006646
|
| MeSH Number(s) |
C08.381.483.375 C15.604.250.400
|
| Concept/Terms |
Histiocytosis, Langerhans-Cell- Histiocytosis, Langerhans-Cell
- Histiocytosis, Langerhans Cell
- Hand-Schueller-Christian Syndrome
- Hand Schueller Christian Syndrome
- Syndrome, Hand-Schueller-Christian
- Hand-Schüller-Christian Disease
- Disease, Hand-Schüller-Christian
- Hand Schüller Christian Disease
- Hand-Schüller-Christian Syndrome
- Hand Schüller Christian Syndrome
- Syndrome, Hand-Schüller-Christian
- Histiocytosis X
- Histiocytosis, Generalized
- Generalized Histiocytoses
- Generalized Histiocytosis
- Histiocytoses, Generalized
- Histiocytosis-X
- Langerhans Cell Histiocytosis
- Cell Histiocytoses, Langerhans
- Cell Histiocytosis, Langerhans
- Histiocytoses, Langerhans Cell
- Langerhans Cell Histiocytoses
- Langerhans-Cell Granulomatosis
- Granulomatosis, Langerhans-Cell
- Langerhans-Cell Histiocytosis
- Letterer-Siwe Disease
- Disease, Letterer-Siwe
- Letterer Siwe Disease
- Non-Lipid Reticuloendotheliosis
- Non Lipid Reticuloendotheliosis
- Non-Lipid Reticuloendothelioses
- Reticuloendothelioses, Non-Lipid
- Reticuloendotheliosis, Non-Lipid
- Schueller-Christian Disease
- Disease, Schueller-Christian
- Schueller Christian Disease
- Systemic Aleukemic Reticuloendotheliosis
- Aleukemic Reticuloendothelioses, Systemic
- Aleukemic Reticuloendotheliosis, Systemic
- Reticuloendothelioses, Systemic Aleukemic
- Reticuloendotheliosis, Systemic Aleukemic
- Systemic Aleukemic Reticuloendothelioses
- Type 2 Histiocytosis
- Histiocytoses, Type 2
- Histiocytosis, Type 2
- Type 2 Histiocytoses
- Langerhans Cell Granulomatosis
- Cell Granulomatoses, Langerhans
- Cell Granulomatosis, Langerhans
- Granulomatoses, Langerhans Cell
- Granulomatosis, Langerhans Cell
- Langerhans Cell Granulomatoses
- Hand-Schueller-Christian Disease
- Disease, Hand-Schueller-Christian
- Hand Schueller Christian Disease
Pulmonary Histiocytosis X- Pulmonary Histiocytosis X
- Histiocytosis X, Pulmonary
- Pulmonary Langerhans Cell Granulomatosis
- Langerhans Cell Granulomatosis, Pulmonary
|
Below are MeSH descriptors whose meaning is more general than "Histiocytosis, Langerhans-Cell".
Below are MeSH descriptors whose meaning is more specific than "Histiocytosis, Langerhans-Cell".
This graph shows the total number of publications written about "Histiocytosis, Langerhans-Cell" by people in this website by year, and whether "Histiocytosis, Langerhans-Cell" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 1998 | 2 | 0 | 2 |
| 2000 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 4 | 0 | 4 |
| 2004 | 4 | 0 | 4 |
| 2005 | 4 | 0 | 4 |
| 2007 | 4 | 0 | 4 |
| 2008 | 2 | 0 | 2 |
| 2009 | 3 | 1 | 4 |
| 2010 | 4 | 0 | 4 |
| 2011 | 2 | 0 | 2 |
| 2012 | 2 | 0 | 2 |
| 2013 | 5 | 0 | 5 |
| 2014 | 8 | 0 | 8 |
| 2015 | 8 | 0 | 8 |
| 2016 | 6 | 0 | 6 |
| 2017 | 7 | 0 | 7 |
| 2018 | 6 | 0 | 6 |
| 2019 | 3 | 1 | 4 |
| 2020 | 5 | 1 | 6 |
| 2021 | 7 | 0 | 7 |
| 2022 | 5 | 0 | 5 |
| 2023 | 6 | 0 | 6 |
| 2024 | 5 | 1 | 6 |
| 2025 | 4 | 0 | 4 |
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click here.
Below are the most recent publications written about "Histiocytosis, Langerhans-Cell" by people in Profiles.
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Histiocyte Society blueprint for Langerhans cell histiocytosis research: from cell-of-origin to a more comprehensive cure. Haematologica. 2025 Nov 01; 110(11):2588-2602.
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BRAF V600E-positive mononuclear cells in blood at diagnosis portend treatment failure and neurodegeneration in pediatric LCH. Blood. 2025 Jul 10; 146(2):206-218.
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Langerhans cell histiocytosis: NACHO update on progress, chaos, and opportunity on the path to rational cures. Cancer. 2024 Jul 15; 130(14):2416-2439.
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Clofarabine monotherapy in aggressive, relapsed and refractory Langerhans cell histiocytosis. Br J Haematol. 2024 May; 204(5):1888-1893.
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Langerhans cell histiocytosis: Version 2021. Hematol Oncol. 2021 Jun; 39 Suppl 1:15-23.
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The global challenge of treating disseminated LCH. Pediatr Hematol Oncol. 2020 Nov; 37(8):653-655.
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Circulating CD1c+ myeloid dendritic cells are potential precursors to LCH lesion CD1a+CD207+ cells. Blood Adv. 2020 01 14; 4(1):87-99.
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Clinical responses and persistent BRAF V600E+ blood cells in children with LCH treated with MAPK pathway inhibition. Blood. 2019 04 11; 133(15):1691-1694.
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Rituximab therapy for patients with Langerhans cell histiocytosis-associated neurologic dysfunction. Pediatr Hematol Oncol. 2018 Oct - Nov; 35(7-8):427-433.
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Anti TNF-a therapy in patients with relapsed and refractory Langerhans cell histiocytosis: a phase II study. Pediatr Hematol Oncol. 2018 Aug - Sep; 35(5-6):362-368.