"Presenilins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Integral membrane proteins and essential components of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. Mutations of presenilins lead to presenile ALZHEIMER DISEASE with onset before age 65 years.
| Descriptor ID |
D053763
|
| MeSH Number(s) |
D12.776.543.696
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| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Presenilins".
Below are MeSH descriptors whose meaning is more specific than "Presenilins".
This graph shows the total number of publications written about "Presenilins" by people in this website by year, and whether "Presenilins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 1 | 1 | 2 |
| 2009 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Presenilins" by people in Profiles.
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Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency. Cell Rep. 2016 Mar 08; 14(9):2166-2179.
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Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of A? and tau. PLoS One. 2013; 8(11):e80706.
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Antioxidant proteins TSA and PAG interact synergistically with Presenilin to modulate Notch signaling in Drosophila. Protein Cell. 2011 Jul; 2(7):554-63.
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Modulation of gamma-secretase specificity using small molecule allosteric inhibitors. Proc Natl Acad Sci U S A. 2009 Dec 01; 106(48):20228-33.
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Genetic dissection of gamma-secretase-dependent and -independent functions of presenilin in regulating neuronal cell cycle and cell death. J Neurosci. 2008 Oct 29; 28(44):11421-31.
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Dimorphic effects of Notch signaling in bone homeostasis. Nat Med. 2008 Mar; 14(3):299-305.