"Presenilin-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN2 mutations cause ALZHEIMER DISEASE type 4.
| Descriptor ID |
D053766
|
| MeSH Number(s) |
D12.776.543.696.750
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Presenilin-2".
Below are MeSH descriptors whose meaning is more specific than "Presenilin-2".
This graph shows the total number of publications written about "Presenilin-2" by people in this website by year, and whether "Presenilin-2" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 3 | 3 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Presenilin-2" by people in Profiles.
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Plasma amyloid ? levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants. Alzheimers Dement. 2021 10; 17(10):1663-1674.
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Angiotensin converting enzyme 2 is a novel target of the ?-secretase complex. Sci Rep. 2021 05 07; 11(1):9803.
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The impact of the availability of prevention studies on the desire to undergo predictive testing in persons at risk for autosomal dominant Alzheimer's disease. Contemp Clin Trials. 2013 Sep; 36(1):256-62.
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Propositional density and apolipoprotein E genotype among persons at risk for familial Alzheimer's disease. Dement Geriatr Cogn Disord. 2011; 32(3):188-92.
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Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes. J Biol Chem. 2009 Jan 30; 284(5):2967-2977.
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The genetics of very early onset Alzheimer disease. Cogn Behav Neurol. 2007 Sep; 20(3):149-56.
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Functional characterization of novel presenilin-2 variants identified in human breast cancers. Oncogene. 2006 Jun 15; 25(25):3557-64.
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Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation. Proc Natl Acad Sci U S A. 2006 Jan 10; 103(2):353-8.
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A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage. J Neurochem. 2006 Jan; 96(1):118-25.
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Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling. FASEB J. 2005 Dec; 19(14):2069-71.