"Axon Initial Segment" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
First segment of axon that connects distal axon segments to the neuronal CELL BODY at the axon hillock region. The axon initial segment is not protected by the MYELIN SHEATH and has properties critical for axonal growth. The axon initial segment and the axon hillock form an axonal trigger zone.
| Descriptor ID |
D000071040
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| MeSH Number(s) |
A08.675.542.145.250 A11.284.180.075.125 A11.671.137.170 A11.671.501.145.250
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Axon Initial Segment".
Below are MeSH descriptors whose meaning is more specific than "Axon Initial Segment".
This graph shows the total number of publications written about "Axon Initial Segment" by people in this website by year, and whether "Axon Initial Segment" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 3 | 0 | 3 |
| 2018 | 1 | 0 | 1 |
| 2020 | 4 | 0 | 4 |
| 2021 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
| 2023 | 2 | 0 | 2 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Axon Initial Segment" by people in Profiles.
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TRIM46 Is Required for Microtubule Fasciculation In Vivo But Not Axon Specification or Axon Initial Segment Formation. J Neurosci. 2024 Oct 16; 44(42).
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Immunoproximity biotinylation reveals the axon initial segment proteome. Nat Commun. 2023 Dec 11; 14(1):8201.
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Antibody-directed extracellular proximity biotinylation reveals that Contactin-1 regulates axo-axonic innervation of axon initial segments. Nat Commun. 2023 10 26; 14(1):6797.
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Axon Initial Segments Are Required for Efficient Motor Neuron Axon Regeneration and Functional Recovery of Synapses. J Neurosci. 2022 10 26; 42(43):8054-8065.
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Endogenously expressed Ranbp2 is not at the axon initial segment. J Cell Sci. 2021 03 11; 134(6).
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Drosophila Voltage-Gated Sodium Channels Are Only Expressed in Active Neurons and Are Localized to Distal Axonal Initial Segment-like Domains. J Neurosci. 2020 10 14; 40(42):7999-8024.
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? spectrin-dependent and domain specific mechanisms for Na+ channel clustering. Elife. 2020 05 19; 9.
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NuMA1 promotes axon initial segment assembly through inhibition of endocytosis. J Cell Biol. 2020 02 03; 219(2).
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Mapping axon initial segment structure and function by multiplexed proximity biotinylation. Nat Commun. 2020 01 03; 11(1):100.
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Axon initial segments: structure, function, and disease. Ann N Y Acad Sci. 2018 05; 1420(1):46-61.