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LOUISE HECKER

TitleClinical Associate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
Address1840 Dynamic Way
ORCID ORCID Icon0000-0002-5025-5437 Additional info
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tang H, Gupta A, Morrisroe SA, Bao C, Schwantes-An TH, Gupta G, Liang S, Sun Y, Chu A, Luo A, Ramamoorthi Elangovan V, Sangam S, Shi Y, Naidu SR, Jheng JR, Ciftci-Yilmaz S, Warfel NA, Hecker L, Mitra S, Coleman AW, Lutz KA, Pauciulo MW, Lai YC, Javaheri A, Dharmakumar R, Wu WH, Flaherty DP, Karnes JH, Breuils-Bonnet S, Boucherat O, Bonnet S, Yuan JX, Jacobson JR, Duarte JD, Nichols WC, Garcia JGN, Desai AA, Wu WH, Breuils-Bonnet S, Boucherat O, Bonnet S. Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension. Circulation. 2024 Jul 23; 150(4):302-316. PMID: 38695173; PMCID: PMC11262989.
      Citations:    
    2. Vukmirovic M, Benam KH, Rose JJ, Turner S, Magin CM, Lagares D, Cohen AH, Kaminski N, Hirota JA, Maher TM, Konigshoff M, Mallampalli RK, Sheppard D, Tarran R, Gomer RH, Kenyon NJ, Morris D, Hobbie S, Raju SV, Petrache I, Watkins T, Kumar R, Lam WA, Sherer T, Hecker L. Challenges and Opportunities for Commercializing Technologies in the Pulmonary Arena: An Official American Thoracic Society Report. Ann Am Thorac Soc. 2024 Jan; 21(1):1-11. PMID: 37903340; PMCID: PMC10867911.
      Citations:    
    3. Sharma NS, Patel K, Sari E, Shankar S, Gastanadui MG, Moncada-Giraldo D, Soto-Vazquez Y, Stacks D, Hecker L, Dsouza K, Banday M, O'Neill E, Benson P, Payne G, Margaroli C, Gaggar A. Active transcription in the vascular bed characterizes rapid progression in idiopathic pulmonary fibrosis. J Clin Invest. 2023 08 15; 133(16). PMID: 37384419; PMCID: PMC10425209.
      Citations:    
    4. HECKER L, Kato K, Griendling K. NADPH Oxidases Revisited: From Function to Structure. Nox4: From Discovery to Pathophysiology. 2023; 179-214.
    5. Robinson S, Parigoris E, Chang J, Hecker L, Takayama S. Contracting scars from fibrin drops. Integr Biol (Camb). 2022 03 21; 14(1):1-12. PMID: 35184163; PMCID: PMC8934703.
      Citations:    
    6. Kato K, Papageorgiou I, Shin YJ, Kleinhenz JM, Palumbo S, Hahn S, Irish JD, Rounseville SP, Knox KS, Hecker L. Lung-Targeted Delivery of Dimethyl Fumarate Promotes the Reversal of Age-Dependent Established Lung Fibrosis. Antioxidants (Basel). 2022 Feb 28; 11(3). PMID: 35326142; PMCID: PMC8944574.
      Citations:    
    7. Kato K, Shin YJ, Palumbo S, Papageorgiou I, Hahn S, Irish JD, Rounseville SP, Krafty RT, Wollin L, Sauler M, Hecker L. Leveraging ageing models of pulmonary fibrosis: the efficacy of nintedanib in ageing. Eur Respir J. 2021 11; 58(5). PMID: 34531276; PMCID: PMC8613836.
      Citations:    
    8. Robinson S, Chang J, Parigoris E, Hecker L, Takayama S. Aqueous two-phase deposition and fibrinolysis of fibroblast-laden fibrin micro-scaffolds. Biofabrication. 2021 04 07; 13(3). PMID: 33440354; PMCID: PMC8282251.
      Citations:    
    9. Kato K, Chang EH, Chen Y, Lu W, Kim MM, Niihori M, Hecker L, Kim KC. MUC1 contributes to goblet cell metaplasia and MUC5AC expression in response to cigarette smoke in vivo. Am J Physiol Lung Cell Mol Physiol. 2020 07 01; 319(1):L82-L90. PMID: 32401676; PMCID: PMC7468848.
      Citations:    
    10. Kato K, Logsdon NJ, Shin YJ, Palumbo S, Knox A, Irish JD, Rounseville SP, Rummel SR, Mohamed M, Ahmad K, Trinh JM, Kurundkar D, Knox KS, Thannickal VJ, Hecker L. Impaired Myofibroblast Dedifferentiation Contributes to Nonresolving Fibrosis in Aging. Am J Respir Cell Mol Biol. 2020 05; 62(5):633-644. PMID: 31962055; PMCID: PMC7193787.
      Citations:    
    11. Kato K, Hecker L. NADPH oxidases: Pathophysiology and therapeutic potential in age-associated pulmonary fibrosis. Redox Biol. 2020 06; 33:101541. PMID: 32360174; PMCID: PMC7251244.
      Citations:    
    12. Viola H, Chang J, Grunwell JR, Hecker L, Tirouvanziam R, Grotberg JB, Takayama S. Microphysiological systems modeling acute respiratory distress syndrome that capture mechanical force-induced injury-inflammation-repair. APL Bioeng. 2019 Dec; 3(4):041503. PMID: 31768486; PMCID: PMC6874511.
      Citations:    
    13. Hecker L. Mechanisms and consequences of oxidative stress in lung disease: therapeutic implications for an aging populace. Am J Physiol Lung Cell Mol Physiol. 2018 04 01; 314(4):L642-L653. PMID: 29351446; PMCID: PMC5966777.
      Citations:    
    14. Ding Q, Subramanian I, Luckhardt TR, Che P, Waghray M, Zhao XK, Bone N, Kurundkar AR, Hecker L, Hu M, Zhou Y, Horowitz JC, Vittal R, Thannickal VJ. Focal adhesion kinase signaling determines the fate of lung epithelial cells in response to TGF-?. Am J Physiol Lung Cell Mol Physiol. 2017 06 01; 312(6):L926-L935. PMID: 28360109; PMCID: PMC5495945.
      Citations:    
    15. Palumbo S, Shin YJ, Ahmad K, Desai AA, Quijada H, Mohamed M, Knox A, Sammani S, Colson BA, Wang T, Garcia JG, Hecker L. Dysregulated Nox4 ubiquitination contributes to redox imbalance and age-related severity of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2017 Mar 01; 312(3):L297-L308. PMID: 28062482; PMCID: PMC5374302.
      Citations:    
    16. Wang T, Mathew B, Wu X, Shimizu Y, Rizzo AN, Dudek SM, Weichselbaum RR, Jacobson JR, Hecker L, Garcia JG. Nonmuscle myosin light chain kinase activity modulates radiation-induced lung injury. Pulm Circ. 2016 Jun; 6(2):234-9. PMID: 27252850; PMCID: PMC4869928.
      Citations:    
    17. Bime C, Zhou T, Wang T, Slepian MJ, Garcia JG, Hecker L. Reactive oxygen species-associated molecular signature predicts survival in patients with sepsis. Pulm Circ. 2016 Jun; 6(2):196-201. PMID: 27252846; PMCID: PMC4869924.
      Citations:    
    18. Hecker L, Thannickal VJ. Getting to the core of fibrosis: targeting redox imbalance in aging. Ann Transl Med. 2016 Mar; 4(5):93. PMID: 27047952; PMCID: PMC4791330.
      Citations:    
    19. Joseph B, Khalil M, Hashmi A, Hecker L, Kulvatunyou N, Tang A, Friese RS, Rhee P. Survival benefits of remote ischemic conditioning in sepsis. J Surg Res. 2017 06 01; 213:131-137. PMID: 28601305.
      Citations:    
    20. Casanova NG, Navarrete JR, Quijada H, HECKER L, Garcia JG. Health Disparities in Respiratory Medicine. Health Disparities in ARDS. 2016; 135-146.
    21. Bime C, Gurguis C, HECKER L, Wang T, Desai A, & Garcia, JGN. Translating MicroRNAs to the clinic. MicroRNAs in inflammatory lung diseases. 2016; 135-177.
    22. HECKER L. Convergence: Transdisciplinary Knowledge and Approaches to Education and Public Health. Transdisciplinary Approaches in the Development of Novel Therapies for the Treatment of Fibrotic Diseases. 2016; 135-142.
    23. Qian Z, Zhou T, Gurguis CI, Xu X, Wen Q, Lv J, Fang F, Hecker L, Cress AE, Natarajan V, Jacobson JR, Zhang DD, Garcia JG, Wang T. Nuclear factor, erythroid 2-like 2-associated molecular signature predicts lung cancer survival. Sci Rep. 2015 Nov 24; 5:16889. PMID: 26596768; PMCID: PMC4657037.
      Citations:    
    24. Hecker L, Logsdon NJ, Kurundkar D, Kurundkar A, Bernard K, Hock T, Meldrum E, Sanders YY, Thannickal VJ. Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance. Sci Transl Med. 2014 Apr 09; 6(231):231ra47. PMID: 24718857; PMCID: PMC4545252.
      Citations:    
    25. Bernard K, Hecker L, Luckhardt TR, Cheng G, Thannickal VJ. NADPH oxidases in lung health and disease. Antioxid Redox Signal. 2014 Jun 10; 20(17):2838-53. PMID: 24093231; PMCID: PMC4026303.
      Citations:    
    26. Murphy, K, Logsdon, N, Sessions, S, HECKER L. Secreted Factor(s) from Young Cells Restores Susceptibility to Cell Death in Senescent Myofibroblasts. BIOS. 2014; 4(85):218-223.
    27. Zhou Y, Huang X, Hecker L, Kurundkar D, Kurundkar A, Liu H, Jin TH, Desai L, Bernard K, Thannickal VJ. Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis. J Clin Invest. 2013 Mar; 123(3):1096-108. PMID: 23434591; PMCID: PMC3582144.
      Citations:    
    28. Sanders YY, Liu H, Zhang X, Hecker L, Bernard K, Desai L, Liu G, Thannickal VJ. Histone modifications in senescence-associated resistance to apoptosis by oxidative stress. Redox Biol. 2013; 1:8-16. PMID: 24024133; PMCID: PMC3757696.
      Citations:    
    29. Hecker L, Cheng J, Thannickal VJ. Targeting NOX enzymes in pulmonary fibrosis. Cell Mol Life Sci. 2012 Jul; 69(14):2365-71. PMID: 22618245; PMCID: PMC3710124.
      Citations:    
    30. Hecker L, Thannickal VJ. Nonresolving fibrotic disorders: idiopathic pulmonary fibrosis as a paradigm of impaired tissue regeneration. Am J Med Sci. 2011 Jun; 341(6):431-4. PMID: 21613929.
      Citations:    
    31. Ding Q, Luckhardt T, Hecker L, Zhou Y, Liu G, Antony VB, deAndrade J, Thannickal VJ. New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis. Drugs. 2011 May 28; 71(8):981-1001. PMID: 21668038; PMCID: PMC3955181.
      Citations:    
    32. Hecker L, Jagirdar R, Jin T, Thannickal VJ. Reversible differentiation of myofibroblasts by MyoD. Exp Cell Res. 2011 Aug 01; 317(13):1914-21. PMID: 21440539; PMCID: PMC3123424.
      Citations:    
    33. HECKER L, Crowe DR, and Thannickal VJ. Reply to: “NOX-4 is expressed in thickened pulmonary arteries in idiopathic pulmonary fibrosis.”. Nature Medicine. 2011; 1(17):32-33.
    34. Pennathur S, HECKER L, Thannickal, VJ. Studies on Cardiovascular Disorders – Oxidative Stress in Applied Basic Science and Clinical Practice. Oxidative Stress and Cardiovascular Fibrosis. 2010; 425-441.
    35. Griffith B, Pendyala S, Hecker L, Lee PJ, Natarajan V, Thannickal VJ. NOX enzymes and pulmonary disease. Antioxid Redox Signal. 2009 Oct; 11(10):2505-16. PMID: 19331546; PMCID: PMC2821137.
      Citations:    
    36. Hecker L, Vittal R, Jones T, Jagirdar R, Luckhardt TR, Horowitz JC, Pennathur S, Martinez FJ, Thannickal VJ. NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury. Nat Med. 2009 Sep; 15(9):1077-81. PMID: 19701206; PMCID: PMC2743335.
      Citations: 387     Fields:    Translation:HumansAnimalsCells
    37. Hecker L, Khait L, Radnoti D, Birla R. Novel bench-top perfusion system improves functional performance of bioengineered heart muscle. J Biosci Bioeng. 2009 Feb; 107(2):183-90. PMID: 19217558.
      Citations:    Fields:    Translation:Animals
    38. HECKER L, Thannickal VJ, Phan SH. Basic concepts of molecular pathology. Stem Cells. 2009; 147-151.
    39. Hecker L, Khait L, Sessions SK, Birla RK. Functional evaluation of isolated zebrafish hearts. Zebrafish. 2008 Dec; 5(4):319-22. PMID: 19133830.
      Citations: 11     Fields:    Translation:Animals
    40. Hecker L, Birla RK. The value of integrating policy people and space in research. J Cardiovasc Transl Res. 2009 Mar; 2(1):93-9. PMID: 20559972.
      Citations:    Fields:    Translation:Humans
    41. Hecker L, Khait L, Welsh MJ, Birla R. Bioengineering functional human aortic vascular smooth-muscle strips in vitro. Biotechnol Appl Biochem. 2008 Jul; 50(Pt 3):155-63. PMID: 18052932.
      Citations: 3     Fields:    Translation:HumansCells
    42. Hecker L, Khait L, Radnoti D, Birla R. Development of a microperfusion system for the culture of bioengineered heart muscle. ASAIO J. 2008 May-Jun; 54(3):284-94. PMID: 18496279.
      Citations: 4     Fields:    Translation:AnimalsCells
    43. Khait L, Hecker L, Radnoti D, Birla RK. Micro-perfusion for cardiac tissue engineering: development of a bench-top system for the culture of primary cardiac cells. Ann Biomed Eng. 2008 May; 36(5):713-25. PMID: 18274906.
      Citations: 4     Fields:    Translation:AnimalsCells
    44. Hecker L, Birla RK. Intangible factors leading to success in research: strategy, innovation and leadership. J Cardiovasc Transl Res. 2008 Mar; 1(1):85-92. PMID: 20559961.
      Citations: 2     Fields:    Translation:Humans
    45. Khait L, Hecker L, Blan NR, Coyan G, Migneco F, Huang YC, Birla RK. Getting to the heart of tissue engineering. J Cardiovasc Transl Res. 2008 Mar; 1(1):71-84. PMID: 20559960.
      Citations: 5     Fields:    Translation:Humans
    46. Hecker L, Birla RK. Engineering the heart piece by piece: state of the art in cardiac tissue engineering. Regen Med. 2007 Mar; 2(2):125-44. PMID: 17465746.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    47. Hecker L, Baar K, Dennis RG, Bitar KN. Development of a three-dimensional physiological model of the internal anal sphincter bioengineered in vitro from isolated smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2005 Aug; 289(2):G188-96. PMID: 15774939.
      Citations:    
    48. HECKER L, Madison DM, Dapson RW, Holzherr V. Presence of modified serous glands in the caudal integument of the red-backed salamander (Plethodon cinereus). Journal of Herpetology. 2003; (37):732-736.
    49. Stopper GF, Hecker L, Franssen RA, Sessions SK. How trematodes cause limb deformities in amphibians. J Exp Zool. 2002 Oct 15; 294(3):252-63. PMID: 12362431.
      Citations: 8     Fields:    Translation:Animals
    50. HECKER L. Majoring in Biology Just Isn’t Enough. Bios. 2002; 2(73):66-67.
    51. Sessions SK, Franssen A, Horner V, HECKER L, Stopper G. Update on deformed amphibian research at Hartwick College. Catskill Ecosystem Health. 2001.
    52. HECKER L, Sessions SK. Development analysis of limb deformities in amphibians. BIOS. 2001; 1(72):9-13.
    53. Schlossmacher MG, Ostaszewski BL, Hecker LI, Celi A, Haass C, Chin D, Lieberburg I, Furie BC, Furie B, Selkoe DJ. Detection of distinct isoform patterns of the beta-amyloid precursor protein in human platelets and lymphocytes. Neurobiol Aging. 1992 May-Jun; 13(3):421-34. PMID: 1625772.
      Citations: 8     Fields:    Translation:HumansCells
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