X-ray Repair Cross Complementing Protein 1
"X-ray Repair Cross Complementing Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A poly(ADP)-ribose-binding protein that functions in the rejoining of DNA single-strand breaks that arise following treatment with alkylating agents or ionizing radiation. It interacts with DNA LIGASE III and POLY ADP RIBOSE POLYMERASE in BASE EXCISION REPAIR, and may also function in DNA processing and chromosome recombination in GERM CELLS.
| Descriptor ID |
D000076105
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| MeSH Number(s) |
D12.776.157.687.813 D12.776.260.963 D12.776.660.720.813
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "X-ray Repair Cross Complementing Protein 1".
Below are MeSH descriptors whose meaning is more specific than "X-ray Repair Cross Complementing Protein 1".
This graph shows the total number of publications written about "X-ray Repair Cross Complementing Protein 1" by people in this website by year, and whether "X-ray Repair Cross Complementing Protein 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 5 | 5 |
| 2009 | 0 | 2 | 2 |
| 2011 | 0 | 2 | 2 |
| 2013 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 2 | 1 | 3 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "X-ray Repair Cross Complementing Protein 1" by people in Profiles.
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Genetic predictors of neurocognitive outcomes in survivors of pediatric brain tumors. J Neurooncol. 2023 Oct; 165(1):161-169.
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Proteogenomic Markers of Chemotherapy Resistance and Response in Triple-Negative Breast Cancer. Cancer Discov. 2022 11 02; 12(11):2586-2605.
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On the interplay between dosiomics and genomics in radiation-induced lymphopenia of lung cancer patients. Radiother Oncol. 2022 02; 167:219-225.
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Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus. J Biol Chem. 2021 Aug; 297(2):100921.
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An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIa within a flexible DNA repair complex. Nucleic Acids Res. 2021 01 11; 49(1):306-321.
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Radiation-induced lymphopenia during chemoradiation therapy for non-small cell lung cancer is linked with age, lung V5, and XRCC1 rs25487 genotypes in lymphocytes. Radiother Oncol. 2021 01; 154:187-193.
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Identification of an XRCC1 DNA binding activity essential for retention at sites of DNA damage. Sci Rep. 2019 02 28; 9(1):3095.
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Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex. Nucleic Acids Res. 2017 03 17; 45(5):2585-2599.
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Identification of biomarkers for pseudo and true progression of GBM based on radiogenomics study. Oncotarget. 2016 Aug 23; 7(34):55377-55394.
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Polymorphisms in the XRCC1 gene modify survival of bladder cancer patients treated with chemotherapy. Int J Cancer. 2013 Oct 15; 133(8):2004-9.