"T-Box Domain Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Proteins containing a region of conserved sequence, about 200 amino acids long, which encodes a particular sequence specific DNA binding domain (the T-box domain). These proteins are transcription factors that control developmental pathways. The prototype of this family is the mouse Brachyury (or T) gene product.
| Descriptor ID |
D020825
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| MeSH Number(s) |
D12.776.260.725 D12.776.930.850
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "T-Box Domain Proteins".
Below are MeSH descriptors whose meaning is more specific than "T-Box Domain Proteins".
This graph shows the total number of publications written about "T-Box Domain Proteins" by people in this website by year, and whether "T-Box Domain Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 2 | 0 | 2 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 1 | 1 | 2 |
| 2006 | 1 | 1 | 2 |
| 2007 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 2 | 3 |
| 2013 | 3 | 3 | 6 |
| 2014 | 2 | 1 | 3 |
| 2015 | 1 | 3 | 4 |
| 2016 | 2 | 3 | 5 |
| 2017 | 0 | 2 | 2 |
| 2018 | 2 | 0 | 2 |
| 2019 | 8 | 2 | 10 |
| 2020 | 1 | 3 | 4 |
| 2021 | 1 | 1 | 2 |
| 2022 | 1 | 4 | 5 |
| 2023 | 3 | 0 | 3 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "T-Box Domain Proteins" by people in Profiles.
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Highly Variable Expressivity of a CNV Deletion Involving TBX4 in Three Deceased Siblings With Lung Developmental Disorder and Their Mildly Affected Mother and Grandfather. Clin Genet. 2026 Jan; 109(1):161-166.
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Diminished TMEM100 Expression in a Newborn With Acinar Dysplasia and a Novel TBX4 Variant: A Case Report. Pediatr Dev Pathol. 2024 May-Jun; 27(3):255-259.
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Lymphatic endothelial transcription factor Tbx1 promotes an immunosuppressive microenvironment to facilitate post-myocardial infarction repair. Immunity. 2023 Oct 10; 56(10):2342-2357.e10.
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Molecular Function and Contribution of TBX4 in Development and Disease. Am J Respir Crit Care Med. 2023 04 01; 207(7):855-864.
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Failure of human rhombic lip differentiation underlies medulloblastoma formation. Nature. 2022 09; 609(7929):1021-1028.
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Functional characteristics of a broad spectrum of TBX6?variants in Mayer-Rokitansky-K?ster-Hauser syndrome. Genet Med. 2022 11; 24(11):2262-2273.
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p63 silencing induces epigenetic modulation to enhance human cardiac fibroblast to cardiomyocyte-like differentiation. Sci Rep. 2022 07 06; 12(1):11416.
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Transcriptome and Immunohistochemical Analyses in TBX4- and FGF10-Deficient Lungs Imply TMEM100 as a Mediator of Human Lung Development. Am J Respir Cell Mol Biol. 2022 06; 66(6):694-697.
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Exacerbation of mild lung disorders to lethal pulmonary hypoplasia by a noncoding hypomorphic SNV in a lung-specific enhancer in trans to the frameshifting TBX4 variant. Am J Med Genet A. 2022 05; 188(5):1420-1425.
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Perturbations of genes essential for M?llerian duct and W?lffian duct development in Mayer-Rokitansky-K?ster-Hauser syndrome. Am J Hum Genet. 2021 02 04; 108(2):337-345.