"T-Box Domain Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Proteins containing a region of conserved sequence, about 200 amino acids long, which encodes a particular sequence specific DNA binding domain (the T-box domain). These proteins are transcription factors that control developmental pathways. The prototype of this family is the mouse Brachyury (or T) gene product.
| Descriptor ID |
D020825
|
| MeSH Number(s) |
D12.776.260.725 D12.776.930.850
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "T-Box Domain Proteins".
Below are MeSH descriptors whose meaning is more specific than "T-Box Domain Proteins".
This graph shows the total number of publications written about "T-Box Domain Proteins" by people in this website by year, and whether "T-Box Domain Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 2 | 0 | 2 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 1 | 2 |
| 2006 | 1 | 1 | 2 |
| 2007 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 1 | 2 |
| 2010 | 0 | 2 | 2 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 1 | 2 |
| 2013 | 2 | 2 | 4 |
| 2014 | 3 | 2 | 5 |
| 2015 | 2 | 2 | 4 |
| 2016 | 4 | 3 | 7 |
| 2017 | 0 | 1 | 1 |
| 2018 | 3 | 0 | 3 |
| 2019 | 8 | 2 | 10 |
| 2020 | 2 | 3 | 5 |
| 2021 | 2 | 1 | 3 |
| 2022 | 2 | 4 | 6 |
| 2023 | 2 | 0 | 2 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "T-Box Domain Proteins" by people in Profiles.
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The Glu86 Residue in TBX4 Proves Critical for Human Lung Development. Am J Med Genet A. 2025 Mar; 197(3):e63936.
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Epigenomic and Transcriptomic Profiling of Solitary Fibrous Tumors Identifies Site-Specific Patterns and Candidate Genes Regulated by DNA Methylation. Lab Invest. 2024 Nov; 104(11):102146.
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HIF-2a-dependent induction of miR-29a restrains TH1 activity during T cell dependent colitis. Nat Commun. 2024 Sep 14; 15(1):8042.
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T-bet suppresses proliferation of malignant B cells in chronic lymphocytic leukemia. Blood. 2024 08 01; 144(5):510-524.
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A phase 2 study of a brachyury-targeting vaccine in combination with radiation therapy for the treatment of advanced chordoma. Cancer. 2024 Nov 15; 130(22):3845-3854.
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Diminished TMEM100 Expression in a Newborn With Acinar Dysplasia and a Novel TBX4 Variant: A Case Report. Pediatr Dev Pathol. 2024 May-Jun; 27(3):255-259.
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Molecular Function and Contribution of TBX4 in Development and Disease. Am J Respir Crit Care Med. 2023 04 01; 207(7):855-864.
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Failure of human rhombic lip differentiation underlies medulloblastoma formation. Nature. 2022 09; 609(7929):1021-1028.
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Functional characteristics of a broad spectrum of TBX6?variants in Mayer-Rokitansky-K?ster-Hauser syndrome. Genet Med. 2022 11; 24(11):2262-2273.
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p63 silencing induces epigenetic modulation to enhance human cardiac fibroblast to cardiomyocyte-like differentiation. Sci Rep. 2022 07 06; 12(1):11416.