"T-Box Domain Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Proteins containing a region of conserved sequence, about 200 amino acids long, which encodes a particular sequence specific DNA binding domain (the T-box domain). These proteins are transcription factors that control developmental pathways. The prototype of this family is the mouse Brachyury (or T) gene product.
Descriptor ID |
D020825
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MeSH Number(s) |
D12.776.260.725 D12.776.930.850
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "T-Box Domain Proteins".
Below are MeSH descriptors whose meaning is more specific than "T-Box Domain Proteins".
This graph shows the total number of publications written about "T-Box Domain Proteins" by people in this website by year, and whether "T-Box Domain Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1995 | 1 | 0 | 1 |
1999 | 3 | 0 | 3 |
2000 | 1 | 0 | 1 |
2001 | 0 | 1 | 1 |
2002 | 0 | 1 | 1 |
2003 | 0 | 1 | 1 |
2004 | 2 | 2 | 4 |
2005 | 1 | 1 | 2 |
2006 | 2 | 1 | 3 |
2007 | 2 | 0 | 2 |
2008 | 1 | 1 | 2 |
2009 | 2 | 2 | 4 |
2010 | 1 | 3 | 4 |
2011 | 3 | 1 | 4 |
2012 | 2 | 1 | 3 |
2013 | 5 | 4 | 9 |
2014 | 5 | 3 | 8 |
2015 | 4 | 3 | 7 |
2016 | 4 | 2 | 6 |
2017 | 1 | 3 | 4 |
2018 | 3 | 2 | 5 |
2019 | 8 | 3 | 11 |
2020 | 2 | 3 | 5 |
2021 | 2 | 1 | 3 |
2022 | 2 | 4 | 6 |
2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "T-Box Domain Proteins" by people in Profiles.
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Molecular Function and Contribution of TBX4 in Development and Disease. Am J Respir Crit Care Med. 2023 04 01; 207(7):855-864.
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Failure of human rhombic lip differentiation underlies medulloblastoma formation. Nature. 2022 09; 609(7929):1021-1028.
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Functional characteristics of a broad spectrum of TBX6?variants in Mayer-Rokitansky-K?ster-Hauser syndrome. Genet Med. 2022 11; 24(11):2262-2273.
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p63 silencing induces epigenetic modulation to enhance human cardiac fibroblast to cardiomyocyte-like differentiation. Sci Rep. 2022 07 06; 12(1):11416.
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Transcriptome and Immunohistochemical Analyses in TBX4- and FGF10-Deficient Lungs Imply TMEM100 as a Mediator of Human Lung Development. Am J Respir Cell Mol Biol. 2022 06; 66(6):694-697.
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TBX5 variant with the novel phenotype of mixed-type total anomalous pulmonary venous return in Holt-Oram Syndrome and variable intrafamilial heart defects. Mol Med Rep. 2022 06; 25(6).
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Exacerbation of mild lung disorders to lethal pulmonary hypoplasia by a noncoding hypomorphic SNV in a lung-specific enhancer in trans to the frameshifting TBX4 variant. Am J Med Genet A. 2022 05; 188(5):1420-1425.
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Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development. Elife. 2021 10 13; 10.
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Perturbations of genes essential for M?llerian duct and W?lffian duct development in Mayer-Rokitansky-K?ster-Hauser syndrome. Am J Hum Genet. 2021 02 04; 108(2):337-345.
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Potential interactions between the TBX4-FGF10 and SHH-FOXF1 signaling during human lung development revealed using ChIP-seq. Respir Res. 2021 Jan 21; 22(1):26.