p300-CBP Transcription Factors
"p300-CBP Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of histone acetyltransferases that is structurally-related to CREB-BINDING PROTEIN and to E1A-ASSOCIATED P300 PROTEIN. They function as transcriptional coactivators by bridging between DNA-binding TRANSCRIPTION FACTORS and the basal transcription machinery. They also modify transcription factors and CHROMATIN through ACETYLATION.
| Descriptor ID |
D050880
|
| MeSH Number(s) |
D08.811.913.050.134.415.500.575 D12.776.930.680
|
| Concept/Terms |
p300-CBP Transcription Factors- p300-CBP Transcription Factors
- Transcription Factors, p300-CBP
- p300 CBP Transcription Factors
- p300-CBP Coactivator
- Coactivator, p300-CBP
- p300 CBP Coactivator
- p300-CBP Protein
- p300 CBP Protein
|
Below are MeSH descriptors whose meaning is more general than "p300-CBP Transcription Factors".
Below are MeSH descriptors whose meaning is more specific than "p300-CBP Transcription Factors".
This graph shows the total number of publications written about "p300-CBP Transcription Factors" by people in this website by year, and whether "p300-CBP Transcription Factors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2006 | 2 | 0 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 3 | 4 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 2 | 0 | 2 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "p300-CBP Transcription Factors" by people in Profiles.
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KAT tales: Functions of Gcn5 and PCAF lysine acetyltransferases in SAGA and ATAC. J Biol Chem. 2024 Oct; 300(10):107744.
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Supercharging BRD4 with NUT in carcinoma. Oncogene. 2021 02; 40(8):1396-1408.
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Transcriptional Activation of MYC-Induced Genes by GCN5 Promotes B-cell Lymphomagenesis. Cancer Res. 2020 12 15; 80(24):5543-5553.
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The E2F1 transcription factor and RB tumor suppressor moonlight as DNA repair factors. Cell Cycle. 2020 09; 19(18):2260-2269.
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Complex functions of Gcn5 and Pcaf in development and disease. Biochim Biophys Acta Gene Regul Mech. 2021 02; 1864(2):194609.
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Discovery, Structure-Activity Relationship, and Biological Activity of Histone-Competitive Inhibitors of Histone Acetyltransferases P300/CBP. J Med Chem. 2020 05 14; 63(9):4716-4731.
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Inhibition of histone acetyltransferase GCN5 extends lifespan in both yeast and human cell lines. Aging Cell. 2020 04; 19(4):e13129.
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Targeting the SAGA and ATAC Transcriptional Coactivator Complexes in MYC-Driven Cancers. Cancer Res. 2020 05 15; 80(10):1905-1911.
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E2F1 acetylation directs p300/CBP-mediated histone acetylation at DNA double-strand breaks to facilitate repair. Nat Commun. 2019 10 30; 10(1):4951.
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Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence. Mol Cell. 2019 02 21; 73(4):684-698.e8.