Histone Acetyltransferases
"Histone Acetyltransferases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Enzymes that catalyze acyl group transfer from ACETYL-CoA to HISTONES forming CoA and acetyl-histones.
| Descriptor ID |
D051548
|
| MeSH Number(s) |
D08.811.913.050.134.415.500
|
| Concept/Terms |
Histone Acetyltransferases- Histone Acetyltransferases
- Acetyltransferases, Histone
- Histone Acetylase
- Acetylase, Histone
- Histone Acetyltransferase
- Acetyltransferase, Histone
|
Below are MeSH descriptors whose meaning is more general than "Histone Acetyltransferases".
Below are MeSH descriptors whose meaning is more specific than "Histone Acetyltransferases".
This graph shows the total number of publications written about "Histone Acetyltransferases" by people in this website by year, and whether "Histone Acetyltransferases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 4 | 4 |
| 1998 | 0 | 4 | 4 |
| 1999 | 0 | 8 | 8 |
| 2000 | 0 | 5 | 5 |
| 2001 | 0 | 4 | 4 |
| 2002 | 0 | 10 | 10 |
| 2003 | 0 | 13 | 13 |
| 2004 | 0 | 9 | 9 |
| 2005 | 0 | 14 | 14 |
| 2006 | 6 | 6 | 12 |
| 2007 | 6 | 4 | 10 |
| 2008 | 10 | 2 | 12 |
| 2009 | 7 | 3 | 10 |
| 2010 | 0 | 1 | 1 |
| 2011 | 2 | 0 | 2 |
| 2012 | 2 | 0 | 2 |
| 2014 | 0 | 2 | 2 |
| 2015 | 3 | 2 | 5 |
| 2016 | 1 | 3 | 4 |
| 2018 | 1 | 2 | 3 |
| 2019 | 1 | 0 | 1 |
| 2020 | 3 | 2 | 5 |
| 2021 | 3 | 0 | 3 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Histone Acetyltransferases" by people in Profiles.
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High Clinical Exome Sequencing Diagnostic Rates and Novel Phenotypic Expansions for Nonisolated Microphthalmia, Anophthalmia, and Coloboma. Invest Ophthalmol Vis Sci. 2024 Mar 05; 65(3):25.
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KAT6A mutations in Arboleda-Tham syndrome drive epigenetic regulation of posterior HOXC cluster. Hum Genet. 2023 Dec; 142(12):1705-1720.
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Structure-activity relationship and antitumor activity of 1,4-pyrazine-containing inhibitors of histone acetyltransferases P300/CBP. Eur J Med Chem. 2022 Jul 05; 237:114407.
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Epilepsy in KAT6A syndrome: Description of two individuals and revision of the literature. Eur J Med Genet. 2022 Jan; 65(1):104380.
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Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function. Nat Commun. 2021 11 03; 12(1):6340.
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Novel variants in KAT6B spectrum of disorders expand our knowledge of clinical manifestations and molecular mechanisms. Mol Genet Genomic Med. 2021 10; 9(10):e1809.
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CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas. Leukemia. 2020 12; 34(12):3269-3285.
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Further delineation of the clinical spectrum of KAT6B disorders and allelic series of pathogenic variants. Genet Med. 2020 08; 22(8):1338-1347.
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Inhibition of histone acetyltransferase GCN5 extends lifespan in both yeast and human cell lines. Aging Cell. 2020 04; 19(4):e13129.
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Estrogen-induced transcription at individual alleles is independent of receptor level and active conformation but can be modulated by coactivators activity. Nucleic Acids Res. 2020 02 28; 48(4):1800-1810.