Lysine Acetyltransferase 5
"Lysine Acetyltransferase 5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A catalytic subunit of the NuA4 histone acetyltransferase complex that functions in transcriptional activation of genes by acetylation of nucleosomal HISTONES H4 and H2A, altering nucleosome-DNA interactions and interaction of the modified histones with other activating transcription factors. It may control gene expression changes associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest; CELL AGING; APOPTOSIS; and DNA REPAIR. It is polyubiquitinated and degraded during HIV-1 infection through its interaction with the viral TAT PROTEIN.
| Descriptor ID |
D000074443
|
| MeSH Number(s) |
D08.811.913.050.134.415.500.062
|
| Concept/Terms |
Lysine Acetyltransferase 5- Lysine Acetyltransferase 5
- KAT5 (TIP60) Protein
- HIV-1-Tat Interactive Protein Tip60
- HIV 1 Tat Interactive Protein Tip60
- HTATIP
|
Below are MeSH descriptors whose meaning is more general than "Lysine Acetyltransferase 5".
Below are MeSH descriptors whose meaning is more specific than "Lysine Acetyltransferase 5".
This graph shows the total number of publications written about "Lysine Acetyltransferase 5" by people in this website by year, and whether "Lysine Acetyltransferase 5" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Lysine Acetyltransferase 5" by people in Profiles.
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ACTL6A promotes repair of cisplatin-induced DNA damage, a new mechanism of platinum resistance in cancer. Proc Natl Acad Sci U S A. 2021 01 19; 118(3).
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Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer. Cancer Cell. 2014 Feb 10; 25(2):210-25.
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Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency. Immunity. 2012 May 25; 36(5):717-30.
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Partial loss of Tip60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model. Hum Mol Genet. 2011 Jun 01; 20(11):2204-12.
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SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60. J Biol Chem. 2010 Apr 09; 285(15):11458-64.
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Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. Cell. 2009 Mar 20; 136(6):1073-84.
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Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Cell. 2000 Aug 18; 102(4):463-73.