Transcriptional Elongation Factors
"Transcriptional Elongation Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Transcription factors whose primary function is to regulate the rate in which RNA is transcribed.
| Descriptor ID |
D035602
|
| MeSH Number(s) |
D12.776.930.955
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Transcriptional Elongation Factors".
Below are MeSH descriptors whose meaning is more specific than "Transcriptional Elongation Factors".
This graph shows the total number of publications written about "Transcriptional Elongation Factors" by people in this website by year, and whether "Transcriptional Elongation Factors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 1 | 2 |
| 2021 | 1 | 2 | 3 |
| 2022 | 0 | 1 | 1 |
| 2023 | 1 | 0 | 1 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Transcriptional Elongation Factors" by people in Profiles.
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Synthesis, Structure-Activity Relationships, and Antitumor Activities of Quinoxiline-Containing Inhibitors of the Protein-Protein Interactions between Transcription Coactivator AF9/ENL and DOT1L/AF4. J Med Chem. 2025 Sep 25; 68(18):19396-19414.
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The TFIIS N-terminal domain (TND): a transcription assembly module at the interface of order and disorder. Biochem Soc Trans. 2023 02 27; 51(1):125-135.
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A proteolysis-targeting chimera molecule selectively degrades ENL and inhibits malignant gene expression and tumor growth. J Hematol Oncol. 2022 04 08; 15(1):41.
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A ubiquitous disordered protein interaction module orchestrates transcription elongation. Science. 2021 Nov 26; 374(6571):1113-1121.
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Small-molecule inhibitor of AF9/ENL-DOT1L/AF4/AFF4 interactions suppresses malignant gene expression and tumor growth. Theranostics. 2021; 11(17):8172-8184.
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Variants in the degron of AFF3 are associated with intellectual disability, mesomelic dysplasia, horseshoe kidney, and epileptic encephalopathy. Am J Hum Genet. 2021 05 06; 108(5):857-873.
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Acetylation of histone H3K27 signals the transcriptional elongation for estrogen receptor alpha. Commun Biol. 2020 04 07; 3(1):165.
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Germline Elongator mutations in Sonic Hedgehog medulloblastoma. Nature. 2020 04; 580(7803):396-401.
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The capping enzyme facilitates promoter escape and assembly of a follow-on preinitiation complex for reinitiation. Proc Natl Acad Sci U S A. 2019 11 05; 116(45):22573-22582.
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Transcription infidelity and genome integrity: the parallax view. Transcription. 2018; 9(5):315-320.