"Enzyme Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
| Descriptor ID |
D004791
|
| MeSH Number(s) |
D27.505.519.389
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Enzyme Inhibitors".
Below are MeSH descriptors whose meaning is more specific than "Enzyme Inhibitors".
This graph shows the total number of publications written about "Enzyme Inhibitors" by people in this website by year, and whether "Enzyme Inhibitors" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 4 | 9 | 13 |
| 1997 | 6 | 12 | 18 |
| 1998 | 4 | 9 | 13 |
| 1999 | 9 | 16 | 25 |
| 2000 | 6 | 12 | 18 |
| 2001 | 9 | 15 | 24 |
| 2002 | 6 | 28 | 34 |
| 2003 | 9 | 20 | 29 |
| 2004 | 4 | 19 | 23 |
| 2005 | 7 | 18 | 25 |
| 2006 | 9 | 11 | 20 |
| 2007 | 10 | 12 | 22 |
| 2008 | 4 | 15 | 19 |
| 2009 | 5 | 14 | 19 |
| 2010 | 5 | 9 | 14 |
| 2011 | 4 | 1 | 5 |
| 2012 | 6 | 11 | 17 |
| 2013 | 6 | 4 | 10 |
| 2014 | 8 | 7 | 15 |
| 2015 | 11 | 8 | 19 |
| 2016 | 10 | 6 | 16 |
| 2017 | 11 | 7 | 18 |
| 2018 | 3 | 5 | 8 |
| 2019 | 4 | 4 | 8 |
| 2020 | 6 | 3 | 9 |
| 2021 | 7 | 4 | 11 |
| 2022 | 1 | 5 | 6 |
| 2023 | 2 | 3 | 5 |
| 2025 | 3 | 0 | 3 |
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Below are the most recent publications written about "Enzyme Inhibitors" by people in Profiles.
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Discovery of Bis-Acyl Hydrazides as Potent and Bioavailable MTA-Cooperative PRMT5 Inhibitors: A Case Study of Leveraging the Deuterium Kinetic Isotope Effect. J Med Chem. 2026 Jan 08; 69(1):289-304.
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Chemotype- and Target-Driven Genome Mining for a New Natural Product Inhibitor of Bacterial Peptide Deformylase. J Am Chem Soc. 2025 Jun 25; 147(25):21400-21407.
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Role of the Mobile Active Site Flap in IMP Dehydrogenase Inhibitor Binding. ACS Infect Dis. 2025 Feb 14; 11(2):442-452.
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Targeting glutamine dependence with DRP-104 inhibits proliferation and tumor growth of castration-resistant prostate cancer. Prostate. 2024 Mar; 84(4):349-357.
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Modulation of the proteostasis network promotes tumor resistance to oncogenic KRAS inhibitors. Science. 2023 09 08; 381(6662):eabn4180.
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A novel small molecule inhibitor of p38? MAP kinase augments cardiomyocyte cell cycle entry in response to direct cell cycle stimulation. Br J Pharmacol. 2023 12; 180(24):3271-3289.
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Nonresponse to Heart?Failure?Therapy: An Important Trajectory. JACC Heart Fail. 2023 06; 11(6):729-732.
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Targeting tumor endothelial cells with methyltransferase inhibitors: Mechanisms of action and the potential of combination therapy. Pharmacol Ther. 2023 07; 247:108434.
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Therapeutic Response in Pediatric Neuromyelitis Optica Spectrum Disorder. Neurology. 2023 02 28; 100(9):e985-e994.
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IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia. EMBO Mol Med. 2023 01 11; 15(1):e15631.