"IMP Dehydrogenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the dehydrogenation of inosine 5'-phosphate to xanthosine 5'-phosphate in the presence of NAD. EC 1.1.1.205.
| Descriptor ID |
D007168
|
| MeSH Number(s) |
D08.811.682.047.820.450
|
| Concept/Terms |
IMP Dehydrogenase- IMP Dehydrogenase
- Dehydrogenase, IMP
- Inosinic Acid Dehydrogenase
- Acid Dehydrogenase, Inosinic
- Dehydrogenase, Inosinic Acid
- Inosine-5-Monophosphate Dehydrogenase
- Dehydrogenase, Inosine-5-Monophosphate
- Inosine 5 Monophosphate Dehydrogenase
|
Below are MeSH descriptors whose meaning is more general than "IMP Dehydrogenase".
Below are MeSH descriptors whose meaning is more specific than "IMP Dehydrogenase".
This graph shows the total number of publications written about "IMP Dehydrogenase" by people in this website by year, and whether "IMP Dehydrogenase" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2012 | 3 | 0 | 3 |
| 2013 | 2 | 1 | 3 |
| 2014 | 1 | 0 | 1 |
| 2015 | 2 | 0 | 2 |
| 2017 | 3 | 0 | 3 |
| 2018 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 1 | 2 |
| 2021 | 1 | 1 | 2 |
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Below are the most recent publications written about "IMP Dehydrogenase" by people in Profiles.
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A highly conserved zebrafish IMPDH retinal isoform produces the majority of guanine and forms dynamic protein filaments in photoreceptor cells. J Biol Chem. 2022 01; 298(1):101441.
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The Enzymatic Activity of Inosine 5'-Monophosphate Dehydrogenase May Not Be a Vulnerable Target for Staphylococcus aureus Infections. ACS Infect Dis. 2021 11 12; 7(11):3062-3076.
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Mycophenolic anilides as broad specificity inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors. Bioorg Med Chem Lett. 2020 12 15; 30(24):127543.
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Results of a Phase 1/2a dose-escalation study of FF-10501-01, an IMPDH inhibitor, in patients with acute myeloid leukemia or myelodysplastic syndromes. Leuk Lymphoma. 2020 08; 61(8):1943-1953.
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Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell. Proc Natl Acad Sci U S A. 2019 10 15; 116(42):21160-21165.
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Expanding Benzoxazole-Based Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents. J Med Chem. 2018 06 14; 61(11):4739-4756.
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Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia. Nature. 2018 01 25; 553(7689):511-514.
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Benzoxazoles, Phthalazinones, and Arylurea-Based Compounds with IMP Dehydrogenase-Independent Antibacterial Activity against Francisella tularensis. Antimicrob Agents Chemother. 2017 10; 61(10).
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Preclinical activity of FF-10501-01, a novel inosine-5'-monophosphate dehydrogenase inhibitor, in acute myeloid leukemia. Leuk Res. 2017 08; 59:85-92.
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Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016). Expert Opin Ther Pat. 2017 Jun; 27(6):677-690.