"Aldo-Keto Reductases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of NADPH-dependent oxidoreductases that reduce carbonyl substrates including sugar-aldehydes, KETOSTEROIDS; keto-prostaglandins, and QUINONES. They are monomers of approximately 37 KDa and are characterized by a parallel beta-8 (BETA SHEET)-alpha 8 (ALPHA HELICES)-barrel structure that contains the NADP binding site. This conformation favors aromatic and apolar substrates.
| Descriptor ID |
D000074408
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| MeSH Number(s) |
D08.811.682.047.150.700.156 D08.811.682.047.820.284
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| Concept/Terms |
Aldo-Keto Reductases- Aldo-Keto Reductases
- Aldo Keto Reductases
- Reductases, Aldo-Keto
- Aldo-Keto Reductase Superfamily
- Aldo Keto Reductase Superfamily
- Aldo-Keto Reductase Family
- Aldo Keto Reductase Family
|
Below are MeSH descriptors whose meaning is more general than "Aldo-Keto Reductases".
Below are MeSH descriptors whose meaning is more specific than "Aldo-Keto Reductases".
This graph shows the total number of publications written about "Aldo-Keto Reductases" by people in this website by year, and whether "Aldo-Keto Reductases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
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Below are the most recent publications written about "Aldo-Keto Reductases" by people in Profiles.
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Aldose reductase promotes diet-induced obesity via induction of senescence in subcutaneous adipose tissue. Obesity (Silver Spring). 2022 08; 30(8):1647-1658.
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Modulation of voltage-dependent Shaker family potassium channels by an aldo-keto reductase. J Biol Chem. 2006 Jun 02; 281(22):15194-200.
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A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13. J Lipid Res. 2003 Mar; 44(3):503-11.
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Characterization of a novel murine aldo-keto reductase. Adv Exp Med Biol. 1997; 414:455-64.
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1.7 A structure of FR-1, a fibroblast growth factor-induced member of the aldo-keto reductase family, complexed with coenzyme and inhibitor. Biochemistry. 1995 Nov 07; 34(44):14323-30.
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Expression, crystallization and preliminary crystallographic analysis of human carbonyl reductase. J Mol Biol. 1994 Dec 16; 244(5):659-64.
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Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein. J Biol Chem. 1988 Nov 05; 263(31):16185-8.