"L-Lactate Dehydrogenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.
| Descriptor ID |
D007770
|
| MeSH Number(s) |
D08.811.682.047.551.400 D08.811.682.047.820.493
|
| Concept/Terms |
L-Lactate Dehydrogenase- L-Lactate Dehydrogenase
- Dehydrogenase, L-Lactate
- L Lactate Dehydrogenase
- Lactate Dehydrogenase
- Dehydrogenase, Lactate
|
Below are MeSH descriptors whose meaning is more general than "L-Lactate Dehydrogenase".
Below are MeSH descriptors whose meaning is more specific than "L-Lactate Dehydrogenase".
This graph shows the total number of publications written about "L-Lactate Dehydrogenase" by people in this website by year, and whether "L-Lactate Dehydrogenase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 |
| 1999 | 0 | 1 | 1 |
| 2000 | 2 | 4 | 6 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 1 | 2 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 2 | 2 |
| 2008 | 1 | 1 | 2 |
| 2010 | 2 | 0 | 2 |
| 2011 | 0 | 2 | 2 |
| 2012 | 1 | 0 | 1 |
| 2014 | 2 | 1 | 3 |
| 2015 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2020 | 1 | 2 | 3 |
| 2021 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2024 | 1 | 2 | 3 |
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Below are the most recent publications written about "L-Lactate Dehydrogenase" by people in Profiles.
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Divergent responses of human intestinal organoid monolayers using commercial in vitro cytotoxicity assays. PLoS One. 2024; 19(6):e0304526.
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Simplified Risk Stratification Model for Patients With Waldenstr?m Macroglobulinemia. J Clin Oncol. 2024 Jul 20; 42(21):2527-2536.
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Mechanisms of gelofusine protection in an in vitro model of polymyxin B-associated renal injury. Am J Physiol Renal Physiol. 2024 Jul 01; 327(1):F137-F145.
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Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase. Science. 2023 03 10; 379(6636):996-1003.
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Diagnostic value of lactate dehydrogenase in COVID-19: A systematic review and meta-analysis. Cardiol J. 2022; 29(5):751-758.
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Excess exogenous pyruvate inhibits lactate dehydrogenase activity in live cells in an MCT1-dependent manner. J Biol Chem. 2021 07; 297(1):100775.
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Breast and Lung Effusion Survival Score Models: Improving Survival Prediction in Patients With Malignant Pleural Effusion and Metastasis. Chest. 2021 09; 160(3):1075-1094.
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Development of a rational strategy for integration of lactate dehydrogenase A suppression into therapeutic algorithms for head and neck cancer. Br J Cancer. 2021 05; 124(10):1670-1679.
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The efficacy of anti-programmed cell death protein 1 therapy among patients with metastatic acral and metastatic mucosal melanoma. Cancer Med. 2021 04; 10(7):2293-2299.
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Lactate dehydrogenase level as a COVID-19 severity marker. Am J Emerg Med. 2021 07; 45:638-639.