Structure-Activity Relationship
"Structure-Activity Relationship" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
| Descriptor ID |
D013329
|
| MeSH Number(s) |
G02.111.830 G07.690.773.997
|
| Concept/Terms |
Structure-Activity Relationship- Structure-Activity Relationship
- Relationship, Structure-Activity
- Relationships, Structure-Activity
- Structure Activity Relationship
- Structure-Activity Relationships
|
Below are MeSH descriptors whose meaning is more general than "Structure-Activity Relationship".
Below are MeSH descriptors whose meaning is more specific than "Structure-Activity Relationship".
This graph shows the total number of publications written about "Structure-Activity Relationship" by people in this website by year, and whether "Structure-Activity Relationship" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 30 | 30 |
| 1995 | 0 | 21 | 21 |
| 1996 | 0 | 26 | 26 |
| 1997 | 0 | 14 | 14 |
| 1998 | 0 | 15 | 15 |
| 1999 | 0 | 12 | 12 |
| 2000 | 0 | 20 | 20 |
| 2001 | 0 | 16 | 16 |
| 2002 | 1 | 21 | 22 |
| 2003 | 1 | 23 | 24 |
| 2004 | 0 | 17 | 17 |
| 2005 | 0 | 20 | 20 |
| 2006 | 1 | 28 | 29 |
| 2007 | 0 | 21 | 21 |
| 2008 | 0 | 19 | 19 |
| 2009 | 0 | 27 | 27 |
| 2010 | 0 | 21 | 21 |
| 2011 | 0 | 20 | 20 |
| 2012 | 0 | 29 | 29 |
| 2013 | 0 | 20 | 20 |
| 2014 | 0 | 21 | 21 |
| 2015 | 0 | 27 | 27 |
| 2016 | 0 | 13 | 13 |
| 2017 | 0 | 18 | 18 |
| 2018 | 0 | 17 | 17 |
| 2019 | 0 | 12 | 12 |
| 2020 | 0 | 17 | 17 |
| 2021 | 0 | 23 | 23 |
| 2022 | 0 | 4 | 4 |
| 2023 | 0 | 4 | 4 |
| 2024 | 0 | 7 | 7 |
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click here.
Below are the most recent publications written about "Structure-Activity Relationship" by people in Profiles.
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Novel benzothiazole/benzothiazole thiazolidine-2,4-dione derivatives as potential FOXM1 inhibitors: In silico, synthesis, and in vitro studies. Arch Pharm (Weinheim). 2024 Dec; 357(12):e2400504.
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Exploration of the tunability of BRD4 degradation by DCAF16 trans-labelling covalent glues. Eur J Med Chem. 2024 Dec 05; 279:116904.
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Functional and Structural Characterization of Clinical-Stage Janus Kinase 2 Inhibitors Identifies Determinants for Drug Selectivity. J Med Chem. 2024 Jun 27; 67(12):10012-10024.
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Reversible male contraception by targeted inhibition of serine/threonine kinase 33. Science. 2024 May 24; 384(6698):885-890.
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Chemical screening by time-resolved X-ray scattering to discover allosteric probes. Nat Chem Biol. 2024 Sep; 20(9):1199-1209.
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Lead Compound Development of SRC-3 Inhibitors with Improved Pharmacokinetic Properties and Anticancer Efficacy. J Med Chem. 2024 Apr 11; 67(7):5333-5350.
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Protein-folding chaperones predict structure-function relationships and cancer risk in BRCA1 mutation carriers. Cell Rep. 2024 Feb 27; 43(2):113803.
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Quinazolinone Compounds Have Potent Antiviral Activity against Zika and Dengue Virus. J Med Chem. 2023 08 10; 66(15):10746-10760.
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First-in-Class Dual Targeting Compounds for the Management of Seizures in Glucose Transporter Type 1 Deficiency Syndrome. J Med Chem. 2023 07 27; 66(14):10010-10026.
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A new horizon in the phosphorylated sites of AGA: the structural impact of C163S mutation in aspartylglucosaminuria through molecular dynamics simulation. J Biomol Struct Dyn. 2024 May; 42(8):4313-4324.