Structure-Activity Relationship
"Structure-Activity Relationship" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
| Descriptor ID |
D013329
|
| MeSH Number(s) |
G02.111.830 G07.690.773.997
|
| Concept/Terms |
Structure-Activity Relationship- Structure-Activity Relationship
- Relationship, Structure-Activity
- Relationships, Structure-Activity
- Structure Activity Relationship
- Structure-Activity Relationships
|
Below are MeSH descriptors whose meaning is more general than "Structure-Activity Relationship".
Below are MeSH descriptors whose meaning is more specific than "Structure-Activity Relationship".
This graph shows the total number of publications written about "Structure-Activity Relationship" by people in this website by year, and whether "Structure-Activity Relationship" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 9 | 9 |
| 1996 | 0 | 7 | 7 |
| 1997 | 0 | 6 | 6 |
| 1998 | 0 | 8 | 8 |
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 10 | 10 |
| 2001 | 0 | 12 | 12 |
| 2002 | 1 | 11 | 12 |
| 2003 | 1 | 13 | 14 |
| 2004 | 0 | 13 | 13 |
| 2005 | 0 | 12 | 12 |
| 2006 | 0 | 17 | 17 |
| 2007 | 0 | 13 | 13 |
| 2008 | 0 | 11 | 11 |
| 2009 | 0 | 15 | 15 |
| 2010 | 0 | 16 | 16 |
| 2011 | 0 | 12 | 12 |
| 2012 | 0 | 24 | 24 |
| 2013 | 0 | 18 | 18 |
| 2014 | 0 | 13 | 13 |
| 2015 | 0 | 23 | 23 |
| 2016 | 0 | 11 | 11 |
| 2017 | 0 | 15 | 15 |
| 2018 | 0 | 15 | 15 |
| 2019 | 0 | 11 | 11 |
| 2020 | 0 | 13 | 13 |
| 2021 | 0 | 16 | 16 |
| 2022 | 0 | 4 | 4 |
| 2023 | 0 | 4 | 4 |
| 2024 | 0 | 4 | 4 |
| 2025 | 0 | 3 | 3 |
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Below are the most recent publications written about "Structure-Activity Relationship" by people in Profiles.
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Synthesis, Structure-Activity Relationships, and Antitumor Activities of Quinoxiline-Containing Inhibitors of the Protein-Protein Interactions between Transcription Coactivator AF9/ENL and DOT1L/AF4. J Med Chem. 2025 Sep 25; 68(18):19396-19414.
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Design and Synthesis of Potent and Selective Urea-linked Benzenesulfonamide Analogs as Carbonic Anhydrase II Inhibitors. Eur J Pharm Sci. 2025 Oct 01; 213:107233.
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Development of carbazole-based molecules for inhibition of mutant hSOD1 protein aggregation in Amyotrophic Lateral Sclerosis. Bioorg Med Chem. 2025 Apr 01; 120:118091.
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Structurally diverse chromane meroterpenoids from Rhododendron capitatum with multifunctional neuroprotective effects. Eur J Med Chem. 2025 Feb 05; 283:117188.
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Quinoline-based compounds can inhibit diverse enzymes that act on DNA. Cell Chem Biol. 2024 Dec 19; 31(12):2112-2127.e6.
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Structure-activity optimization of ryanodine receptor modulators for the treatment of catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm. 2025 Jul; 22(7):e192-e204.
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Exploration of the tunability of BRD4 degradation by DCAF16 trans-labelling covalent glues. Eur J Med Chem. 2024 Dec 05; 279:116904.
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Novel benzothiazole/benzothiazole thiazolidine-2,4-dione derivatives as potential FOXM1 inhibitors: In silico, synthesis, and in vitro studies. Arch Pharm (Weinheim). 2024 Dec; 357(12):e2400504.
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Functional and Structural Characterization of Clinical-Stage Janus Kinase 2 Inhibitors Identifies Determinants for Drug Selectivity. J Med Chem. 2024 06 27; 67(12):10012-10024.
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Reversible male contraception by targeted inhibition of serine/threonine kinase 33. Science. 2024 05 24; 384(6698):885-890.