"Down-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
| Descriptor ID |
D015536
|
| MeSH Number(s) |
G02.111.240 G05.308.200 G07.690.773.937
|
| Concept/Terms |
Down-Regulation- Down-Regulation
- Down Regulation
- Downregulation
- Down-Regulation (Physiology)
|
Below are MeSH descriptors whose meaning is more general than "Down-Regulation".
Below are MeSH descriptors whose meaning is more specific than "Down-Regulation".
This graph shows the total number of publications written about "Down-Regulation" by people in this website by year, and whether "Down-Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 2 | 5 | 7 |
| 2000 | 3 | 6 | 9 |
| 2001 | 1 | 4 | 5 |
| 2002 | 4 | 13 | 17 |
| 2003 | 1 | 13 | 14 |
| 2004 | 3 | 21 | 24 |
| 2005 | 2 | 28 | 30 |
| 2006 | 3 | 21 | 24 |
| 2007 | 4 | 14 | 18 |
| 2008 | 5 | 17 | 22 |
| 2009 | 4 | 21 | 25 |
| 2010 | 5 | 27 | 32 |
| 2011 | 5 | 33 | 38 |
| 2012 | 0 | 22 | 22 |
| 2013 | 1 | 24 | 25 |
| 2014 | 5 | 24 | 29 |
| 2015 | 2 | 18 | 20 |
| 2016 | 0 | 21 | 21 |
| 2017 | 6 | 18 | 24 |
| 2018 | 1 | 18 | 19 |
| 2019 | 2 | 20 | 22 |
| 2020 | 0 | 17 | 17 |
| 2021 | 1 | 6 | 7 |
| 2022 | 0 | 2 | 2 |
| 2023 | 0 | 3 | 3 |
| 2024 | 1 | 3 | 4 |
| 2025 | 0 | 3 | 3 |
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Below are the most recent publications written about "Down-Regulation" by people in Profiles.
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Catalpol Protects Against Retinal Ischemia Through Antioxidation, Anti-Ischemia, Downregulation of ?-Catenin, VEGF, and Angiopoietin-2: In Vitro and In Vivo Studies. Int J Mol Sci. 2025 Apr 24; 26(9).
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Anti-Mullerian hormone (AMH) protects ovarian follicle loss by downregulating granulosa cell function in in vitro and in vivo models. J Assist Reprod Genet. 2025 Jun; 42(6):2029-2037.
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Helicobacter pylori virulence factor CagA promotes Snail-mediated epithelial-mesenchymal transition and invasive behavior by downregulating Semaphorin 5A in gastric epithelial cells. Biochem Biophys Res Commun. 2025 03 01; 750:151421.
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Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3. Oncol Res. 2025; 33(1):103-121.
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Age-related TFEB downregulation in proximal tubules causes systemic metabolic disorders and occasional apolipoprotein A4-related amyloidosis. JCI Insight. 2024 Dec 19; 10(3).
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MARK2 variants cause autism spectrum disorder via the downregulation of WNT/?-catenin signaling pathway. Am J Hum Genet. 2024 Nov 07; 111(11):2392-2410.
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Downregulation of UBA1 expression in myelodysplastic neoplasm. Leukemia. 2024 Oct; 38(10):2284-2288.
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Downregulation of Protease Cathepsin D and Upregulation of Pathologic a-Synuclein Mediate Paucity of DNAJC6-Induced Degeneration of Dopaminergic Neurons. Int J Mol Sci. 2024 Jun 18; 25(12).
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REST-dependent downregulation of von Hippel-Lindau tumor suppressor promotes autophagy in SHH-medulloblastoma. Sci Rep. 2024 06 12; 14(1):13596.
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Downregulation of Mirlet7 miRNA family promotes Tc17 differentiation and emphysema via de-repression of ROR?t. Elife. 2024 May 09; 13.