"Down-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
| Descriptor ID |
D015536
|
| MeSH Number(s) |
G02.111.240 G05.308.200 G07.690.773.937
|
| Concept/Terms |
Down-Regulation- Down-Regulation
- Down Regulation
- Downregulation
- Down-Regulation (Physiology)
|
Below are MeSH descriptors whose meaning is more general than "Down-Regulation".
Below are MeSH descriptors whose meaning is more specific than "Down-Regulation".
This graph shows the total number of publications written about "Down-Regulation" by people in this website by year, and whether "Down-Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 2 | 5 | 7 |
| 2000 | 3 | 6 | 9 |
| 2001 | 1 | 5 | 6 |
| 2002 | 3 | 13 | 16 |
| 2003 | 0 | 12 | 12 |
| 2004 | 1 | 19 | 20 |
| 2005 | 2 | 24 | 26 |
| 2006 | 3 | 19 | 22 |
| 2007 | 4 | 13 | 17 |
| 2008 | 4 | 16 | 20 |
| 2009 | 3 | 20 | 23 |
| 2010 | 4 | 22 | 26 |
| 2011 | 4 | 32 | 36 |
| 2012 | 0 | 20 | 20 |
| 2013 | 1 | 19 | 20 |
| 2014 | 5 | 20 | 25 |
| 2015 | 2 | 19 | 21 |
| 2016 | 0 | 21 | 21 |
| 2017 | 6 | 18 | 24 |
| 2018 | 0 | 19 | 19 |
| 2019 | 2 | 19 | 21 |
| 2020 | 0 | 16 | 16 |
| 2021 | 1 | 6 | 7 |
| 2022 | 0 | 2 | 2 |
| 2023 | 0 | 3 | 3 |
| 2024 | 1 | 2 | 3 |
| 2025 | 0 | 4 | 4 |
To return to the timeline,
click here.
Below are the most recent publications written about "Down-Regulation" by people in Profiles.
-
Downregulation of the Tumor Suppressor P53 Gene associated with the Progression of Clinical Staging and the Incidence of Distant Metastasis in Indonesian Colorectal Cancer. Korean J Gastroenterol. 2025 10 25; 85(4):527-536.
-
Catalpol Protects Against Retinal Ischemia Through Antioxidation, Anti-Ischemia, Downregulation of ?-Catenin, VEGF, and Angiopoietin-2: In Vitro and In Vivo Studies. Int J Mol Sci. 2025 Apr 24; 26(9).
-
Anti-Mullerian hormone (AMH) protects ovarian follicle loss by downregulating granulosa cell function in in vitro and in vivo models. J Assist Reprod Genet. 2025 Jun; 42(6):2029-2037.
-
Helicobacter pylori virulence factor CagA promotes Snail-mediated epithelial-mesenchymal transition and invasive behavior by downregulating Semaphorin 5A in gastric epithelial cells. Biochem Biophys Res Commun. 2025 03 01; 750:151421.
-
Age-related TFEB downregulation in proximal tubules causes systemic metabolic disorders and occasional apolipoprotein A4-related amyloidosis. JCI Insight. 2024 Dec 19; 10(3).
-
MARK2 variants cause autism spectrum disorder via the downregulation of WNT/?-catenin signaling pathway. Am J Hum Genet. 2024 Nov 07; 111(11):2392-2410.
-
Downregulation of Mirlet7 miRNA family promotes Tc17 differentiation and emphysema via de-repression of ROR?t. Elife. 2024 May 09; 13.
-
Dominant negative variants in KIF5B cause osteogenesis imperfecta via down regulation of mTOR signaling. PLoS Genet. 2023 11; 19(11):e1011005.
-
Toll-like receptor 2 selectively modulates Ras isoforms expression in Leishmania major infection. Cytokine. 2023 09; 169:156301.
-
Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis. Circ Res. 2023 06 23; 133(1):e1-e16.