"Down-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
| Descriptor ID |
D015536
|
| MeSH Number(s) |
G02.111.240 G05.308.200 G07.690.773.937
|
| Concept/Terms |
Down-Regulation- Down-Regulation
- Down Regulation
- Downregulation
- Down-Regulation (Physiology)
|
Below are MeSH descriptors whose meaning is more general than "Down-Regulation".
Below are MeSH descriptors whose meaning is more specific than "Down-Regulation".
This graph shows the total number of publications written about "Down-Regulation" by people in this website by year, and whether "Down-Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 2 | 5 | 7 |
| 2000 | 4 | 6 | 10 |
| 2001 | 1 | 4 | 5 |
| 2002 | 4 | 13 | 17 |
| 2003 | 1 | 13 | 14 |
| 2004 | 3 | 20 | 23 |
| 2005 | 2 | 28 | 30 |
| 2006 | 5 | 23 | 28 |
| 2007 | 4 | 14 | 18 |
| 2008 | 5 | 17 | 22 |
| 2009 | 3 | 20 | 23 |
| 2010 | 4 | 26 | 30 |
| 2011 | 5 | 32 | 37 |
| 2012 | 0 | 19 | 19 |
| 2013 | 1 | 22 | 23 |
| 2014 | 5 | 19 | 24 |
| 2015 | 2 | 17 | 19 |
| 2016 | 0 | 20 | 20 |
| 2017 | 5 | 16 | 21 |
| 2018 | 1 | 15 | 16 |
| 2019 | 2 | 19 | 21 |
| 2020 | 0 | 13 | 13 |
| 2021 | 1 | 4 | 5 |
| 2022 | 0 | 2 | 2 |
| 2023 | 0 | 3 | 3 |
| 2024 | 1 | 1 | 2 |
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Below are the most recent publications written about "Down-Regulation" by people in Profiles.
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Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3. Oncol Res. 2025; 33(1):103-121.
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MARK2 variants cause autism spectrum disorder via the downregulation of WNT/?-catenin signaling pathway. Am J Hum Genet. 2024 Nov 07; 111(11):2392-2410.
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Downregulation of UBA1 expression in myelodysplastic neoplasm. Leukemia. 2024 Oct; 38(10):2284-2288.
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REST-dependent downregulation of von Hippel-Lindau tumor suppressor promotes autophagy in SHH-medulloblastoma. Sci Rep. 2024 06 12; 14(1):13596.
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Downregulation of Mirlet7 miRNA family promotes Tc17 differentiation and emphysema via de-repression of ROR?t. Elife. 2024 May 09; 13.
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Dominant negative variants in KIF5B cause osteogenesis imperfecta via down regulation of mTOR signaling. PLoS Genet. 2023 Nov; 19(11):e1011005.
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Potentiation of apoptosis in drug-resistant mantle cell lymphoma cells by MCL-1 inhibitor involves downregulation of inhibitor of apoptosis proteins. Cell Death Dis. 2023 11 02; 14(11):714.
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The synergy of the XPO1 inhibitors combined with the BET inhibitor INCB057643 in high-grade B-cell lymphoma via downregulation of MYC expression. Sci Rep. 2023 10 29; 13(1):18554.
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Neutrophil extracellular traps enhance S. aureus skin colonization by oxidative stress induction and downregulation of epidermal barrier genes. Cell Rep. 2023 10 31; 42(10):113148.
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Toll-like receptor 2 selectively modulates Ras isoforms expression in Leishmania major infection. Cytokine. 2023 09; 169:156301.