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ANTONY RODRIGUEZ

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
AddressOne Baylor Plaza
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    Collapse Biography 
    Collapse awards and honors
    Ruth L. Kirschstein Postdoctoral National Research Award , National Institutes of Health
    Junior Faculty Seed Award, Gillson Longebaugh Foundation
    National Scientist Development Award, American Heart Association

    Collapse Overview 
    Collapse overview
    Over the last 10 years, we have focused our research on the identification of microRNAs with important roles in mammalian immunity and cardiopulmonary disease. Our approach is multipronged as we work with genetically modified mice and human samples. During the course of our work, we have identified novel miRNAs involved in adaptive and innate immunity (i.e. miR-155), heart failure (i.e. miR-22), and emphysema (i.e. miR-22). We are currently characterizing the pathophysiology of let-7 miRNA during emphysema/COPD with novel mouse models in collaboration with Drs. Corry and Kheradmand.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Seasock MJ, Shafiquzzaman M, Ruiz-Echartea ME, Kanchi RS, Tran BT, Simon LM, Meyer MD, Erice PA, Lotlikar SL, Wenlock SC, Ochsner SA, Enright A, Carisey AF, Romero F, Rosas IO, King KY, McKenna NJ, Coarfa C, Rodriguez A. Let-7 restrains an oncogenic epigenetic circuit in AT2 cells to prevent ectopic formation of fibrogenic transitional cell intermediates and pulmonary fibrosis. bioRxiv. 2024 May 27. PMID: 38826218; PMCID: PMC11142151.
      Citations:    
    2. Erice PA, Huang X, Seasock MJ, Robertson MJ, Tung HY, Perez-Negron MA, Lotlikar SL, Corry DB, Kheradmand F, Rodriguez A. Downregulation of Mirlet7 miRNA family promotes Tc17 differentiation and emphysema via de-repression of ROR?t. Elife. 2024 May 09; 13. PMID: 38722677; PMCID: PMC11081633.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    3. Erice PA, Huang X, Seasock MJ, Robertson MJ, Tung HY, Perez-Negron MA, Lotlikar SL, Corry DB, Kheradmand F, Rodriguez A. Downregulation of Let-7 miRNA promotes Tc17 differentiation and emphysema via de-repression of ROR?t. bioRxiv. 2024 Mar 04. PMID: 37905101; PMCID: PMC10614797.
      Citations:    
    4. Li E, Rodriguez A, Luong AU, Allen D, Knight JM, Kheradmand F, Corry DB. The immune response to airway mycosis. Curr Opin Microbiol. 2021 08; 62:45-50. PMID: 34052540; PMCID: PMC8286351.
      Citations: 1     Fields:    Translation:Humans
    5. Li E, Knight JM, Wu Y, Luong A, Rodriguez A, Kheradmand F, Corry DB. Airway mycosis in allergic airway disease. Adv Immunol. 2019; 142:85-140. PMID: 31296304.
      Citations: 16     Fields:    Translation:HumansAnimals
    6. Gu BH, Choi JC, Shen YH, Song LZ, Luong A, Rodriguez A, Woodruff P, Koth L, Corry DB, Kheradmand F, LeMaire SA, Scheurer ME. Elastin-Specific Autoimmunity in Smokers With Thoracic Aortic Aneurysm and Dissection is Independent of Chronic Obstructive Pulmonary Disease. J Am Heart Assoc. 2019 04 16; 8(8):e011671. PMID: 30957625; PMCID: PMC6507218.
      Citations: 7     Fields:    Translation:HumansCells
    7. Landers CT, Tung HY, Knight JM, Madison MC, Wu Y, Zeng Z, Porter PC, Rodriguez A, Flick MJ, Kheradmand F, Corry DB. Selective cleavage of fibrinogen by diverse proteinases initiates innate allergic and antifungal immunity through CD11b. J Biol Chem. 2019 05 31; 294(22):8834-8847. PMID: 30992366; PMCID: PMC6552423.
      Citations: 13     Fields:    Translation:AnimalsCells
    8. Robinton DA, Lummertz da Rocha E, Han A, Yermalovich AV, Oginuma M, Schlaeger TM, Sousa P, Rodriguez A, Urbach A, Daley GQ, Chal J, Pourqui? O. The Lin28/let-7 Pathway Regulates the Mammalian Caudal Body Axis Elongation Program. Dev Cell. 2019 02 11; 48(3):396-405.e3. PMID: 30661985.
      Citations: 16     Fields:    Translation:Animals
    9. Li E, Landers CT, Tung HY, Knight JM, Marshall Z, Luong AU, Rodriguez A, Kheradmand F, Corry DB. Fungi in Mucoobstructive Airway Diseases. Ann Am Thorac Soc. 2018 11; 15(Suppl 3):S198-S204. PMID: 30431347; PMCID: PMC6322025.
      Citations: 4     Fields:    Translation:Humans
    10. Kadmon CS, Landers CT, Li HS, Watowich SS, Rodriguez A, King KY. MicroRNA-22 controls interferon alpha production and erythroid maturation in response to infectious stress in mice. Exp Hematol. 2017 12; 56:7-15. PMID: 28911907; PMCID: PMC5696003.
      Citations: 10     Fields:    Translation:AnimalsCells
    11. Rowe RG, Wang LD, Coma S, Han A, Mathieu R, Pearson DS, Ross S, Sousa P, Nguyen PT, Rodriguez A, Wagers AJ, Daley GQ. Developmental regulation of myeloerythroid progenitor function by the Lin28b-let-7-Hmga2 axis. J Exp Med. 2016 07 25; 213(8):1497-512. PMID: 27401346; PMCID: PMC4986532.
      Citations: 31     Fields:    Translation:AnimalsCells
    12. Lu W, You R, Yuan X, Yang T, Samuel EL, Marcano DC, Sikkema WK, Tour JM, Rodriguez A, Kheradmand F, Corry DB. The microRNA miR-22 inhibits the histone deacetylase HDAC4 to promote T(H)17 cell-dependent emphysema. Nat Immunol. 2015 Nov; 16(11):1185-94. PMID: 26437241; PMCID: PMC4597310.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    13. Nam JW, Rissland OS, Koppstein D, Jan CH, Agarwal V, Yildirim MA, Rodriguez A, Bartel DP, Abreu-Goodger C. Global analyses of the effect of different cellular contexts on microRNA targeting. Mol Cell. 2014 Mar 20; 53(6):1031-1043. PMID: 24631284; PMCID: PMC4062300.
      Citations: 147     Fields:    Translation:HumansCells
    14. Long J, Badal SS, Wang Y, Chang BH, Rodriguez A, Danesh FR. MicroRNA-22 is a master regulator of bone morphogenetic protein-7/6 homeostasis in the kidney. J Biol Chem. 2013 Dec 20; 288(51):36202-14. PMID: 24163368; PMCID: PMC3868735.
      Citations: 18     Fields:    Translation:AnimalsCells
    15. Gurha P, Wang T, Larimore AH, Sassi Y, Abreu-Goodger C, Ramirez MO, Reddy AK, Engelhardt S, Taffet GE, Wehrens XH, Entman ML, Rodriguez A. microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription. PLoS One. 2013; 8(9):e75882. PMID: 24086656; PMCID: PMC3785418.
      Citations: 31     Fields:    Translation:AnimalsCells
    16. Harper AR, Mayosi BM, Rodriguez A, Rahman T, Hall D, Mamasoula C, Avery PJ, Keavney BD. Common variation neighbouring micro-RNA 22 is associated with increased left ventricular mass. PLoS One. 2013; 8(1):e55061. PMID: 23372812; PMCID: PMC3555935.
      Citations: 4     Fields:    Translation:Humans
    17. Gurha P, Abreu-Goodger C, Wang T, Ramirez MO, Drumond AL, van Dongen S, Chen Y, Bartonicek N, Enright AJ, Lee B, Kelm RJ, Reddy AK, Taffet GE, Bradley A, Wehrens XH, Entman ML, Rodriguez A. Targeted deletion of microRNA-22 promotes stress-induced cardiac dilation and contractile dysfunction. Circulation. 2012 Jun 05; 125(22):2751-61. PMID: 22570371; PMCID: PMC3503489.
      Citations: 80     Fields:    Translation:AnimalsCells
    18. Vigorito E, Perks KL, Abreu-Goodger C, Bunting S, Xiang Z, Kohlhaas S, Das PP, Miska EA, Rodriguez A, Bradley A, Smith KG, Rada C, Enright AJ, Toellner KM, Maclennan IC, Turner M. microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. Immunity. 2007 Dec; 27(6):847-59. PMID: 18055230; PMCID: PMC4135426.
      Citations: 374     Fields:    Translation:AnimalsCells
    19. Peterson JS, Bass BP, Jue D, Rodriguez A, Abrams JM, McCall K. Noncanonical cell death pathways act during Drosophila oogenesis. Genesis. 2007 Jun; 45(6):396-404. PMID: 17506088.
      Citations: 18     Fields:    Translation:AnimalsCells
    20. Rodriguez A, Vigorito E, Clare S, Warren MV, Couttet P, Soond DR, van Dongen S, Grocock RJ, Das PP, Miska EA, Vetrie D, Okkenhaug K, Enright AJ, Dougan G, Turner M, Bradley A. Requirement of bic/microRNA-155 for normal immune function. Science. 2007 Apr 27; 316(5824):608-11. PMID: 17463290; PMCID: PMC2610435.
      Citations: 892     Fields:    Translation:AnimalsCellsPHPublic Health
    21. Akdemir F, Farkas R, Chen P, Juhasz G, Sass M, Wang L, Wang X, Chittaranjan S, Gorski SM, Rodriguez A, Abrams JM, Medved'ov? L. Autophagy occurs upstream or parallel to the apoptosome during histolytic cell death. Development. 2006 Apr; 133(8):1457-65. PMID: 16540507.
      Citations: 57     Fields:    Translation:AnimalsCells
    22. Sang TK, Li C, Liu W, Rodriguez A, Abrams JM, Zipursky SL, Jackson GR. Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis. Hum Mol Genet. 2005 Feb 01; 14(3):357-72. PMID: 15590702.
      Citations: 27     Fields:    Translation:HumansAnimals
    23. Chew SK, Akdemir F, Chen P, Lu WJ, Mills K, Daish T, Kumar S, Rodriguez A, Abrams JM. The apical caspase dronc governs programmed and unprogrammed cell death in Drosophila. Dev Cell. 2004 Dec; 7(6):897-907. PMID: 15572131.
      Citations: 68     Fields:    Translation:AnimalsCells
    24. Rodriguez A, Griffiths-Jones S, Ashurst JL, Bradley A. Identification of mammalian microRNA host genes and transcription units. Genome Res. 2004 Oct; 14(10A):1902-10. PMID: 15364901; PMCID: PMC524413.
      Citations: 822     Fields:    Translation:Cells
    25. Rodriguez A, Chen P, Oliver H, Abrams JM. Unrestrained caspase-dependent cell death caused by loss of Diap1 function requires the Drosophila Apaf-1 homolog, Dark. EMBO J. 2002 May 01; 21(9):2189-97. PMID: 11980716; PMCID: PMC125994.
      Citations: 35     Fields:    Translation:Animals
    26. Zhou Z, Rodriguez A, Wu CY, Kimbrell DA. Drosophila cellular immune system: Dorothy encodes a UDP glycosyltransferase. Adv Exp Med Biol. 2001; 484:251-63. PMID: 11418991.
      Citations: 2     Fields:    Translation:AnimalsCells
    27. Rodriguez A, Khush RS, Abrams JM, Lemaitre B, Leulier F. The Drosophila caspase Dredd is required to resist gram-negative bacterial infection. EMBO Rep. 2000 Oct; 1(4):353-8. PMID: 11269502; PMCID: PMC1083747.
      Citations: 144     Fields:    Translation:AnimalsCells
    28. Rodriguez A, Oliver H, Zou H, Chen P, Wang X, Abrams JM. Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway. Nat Cell Biol. 1999 Sep; 1(5):272-9. PMID: 10559939.
      Citations: 119     Fields:    Translation:AnimalsCells
    29. Chen P, Rodriguez A, Erskine R, Thach T, Abrams JM. Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila. Dev Biol. 1998 Sep 15; 201(2):202-16. PMID: 9740659.
      Citations: 57     Fields:    Translation:AnimalsCells
    30. Rodriguez A, Chen P, Abrams JM. Molecular prophets of death in the fly. Am J Hum Genet. 1998 Mar; 62(3):514-9. PMID: 9497272; PMCID: PMC1376969.
      Citations: 5     Fields:    Translation:Animals
    31. Williams MJ, Rodriguez A, Kimbrell DA, Eldon ED. The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense. EMBO J. 1997 Oct 15; 16(20):6120-30. PMID: 9321392; PMCID: PMC1326296.
      Citations: 50     Fields:    Translation:Animals
    32. Rodriguez A, Zhou Z, Tang ML, Meller S, Chen J, Bellen H, Kimbrell DA. Identification of immune system and response genes, and novel mutations causing melanotic tumor formation in Drosophila melanogaster. Genetics. 1996 Jun; 143(2):929-40. PMID: 8725239; PMCID: PMC1207349.
      Citations: 37     Fields:    Translation:Animals
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