Pre-B-Cell Leukemia Transcription Factor 1
"Pre-B-Cell Leukemia Transcription Factor 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A TALE-type homeodomain protein and transcription factor that binds the DNA sequence 5'-ATCAATCAA-3'. It forms a heterodimer with MEIS1 TRANSCRIPTION FACTOR and functions as a transcriptional activator of HOMEOBOX PROTEIN NKX-2.5 and ELONGIN A, and as a transcriptional repressor of CDKN2B PROTEIN, in the regulation of developmental and morphogenetic processes such as spleen and limb development. Chromosome translocations involving the PBX1 and TCF3 genes occur in cases of pre-B-cell ACUTE LYMPHOID LEUKEMIA.
| Descriptor ID |
D000075062
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| MeSH Number(s) |
D12.776.260.400.836 D12.776.624.664.700.163 D12.776.930.712
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| Concept/Terms |
Pre-B-Cell Leukemia Transcription Factor 1- Pre-B-Cell Leukemia Transcription Factor 1
- Pre B Cell Leukemia Transcription Factor 1
- PBX1 Homeobox Protein
- Homeobox Protein, PBX1
- Pre-B-Cell Leukemia Homeobox 1 Protein
- Pre B Cell Leukemia Homeobox 1 Protein
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Below are MeSH descriptors whose meaning is more general than "Pre-B-Cell Leukemia Transcription Factor 1".
Below are MeSH descriptors whose meaning is more specific than "Pre-B-Cell Leukemia Transcription Factor 1".
This graph shows the total number of publications written about "Pre-B-Cell Leukemia Transcription Factor 1" by people in this website by year, and whether "Pre-B-Cell Leukemia Transcription Factor 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pre-B-Cell Leukemia Transcription Factor 1" by people in Profiles.
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PBX-WNT-P63-IRF6 pathway in nonsyndromic cleft lip and palate. Birth Defects Res. 2020 02 01; 112(3):234-244.
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Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia. Cancer Cell. 2015 Mar 09; 27(3):409-25.
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A tumorigenic factor interactome connected through tumor suppressor microRNA-198 in human pancreatic cancer. Clin Cancer Res. 2013 Nov 01; 19(21):5901-13.
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Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress. Blood. 2012 Dec 13; 120(25):4973-81.
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Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart disease. Circ Res. 2008 Sep 26; 103(7):702-9.
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FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell. 2007 Jan 26; 128(2):309-23.
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Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins. Mol Cell Biol. 1997 Oct; 17(10):5679-87.
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Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias. Nat Genet. 1996 Feb; 12(2):149-53.