"raf Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of closely-related serine-threonine kinases that were originally identified as the cellular homologs of the retrovirus-derived V-RAF KINASES. They are MAP kinase kinase kinases that play important roles in SIGNAL TRANSDUCTION.
| Descriptor ID |
D048490
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.559.842 D12.644.360.400.842 D12.776.476.400.842 D12.776.624.664.700.204
|
| Concept/Terms |
raf Kinases- raf Kinases
- Kinases, raf
- raf Proto-Oncogene Proteins
- Proto-Oncogene Proteins, raf
- raf Proto Oncogene Proteins
- raf MAP Kinase Kinase Kinases
- raf Serine-Theonine Protein Kinases
- raf Serine Theonine Protein Kinases
- Proto-Oncogene Proteins raf
- Proteins raf, Proto-Oncogene
- Proto Oncogene Proteins raf
mil-raf Protein Kinases- mil-raf Protein Kinases
- Kinases, mil-raf Protein
- Protein Kinases, mil-raf
- mil raf Protein Kinases
- MIL-RAF Proteins
- MIL RAF Proteins
|
Below are MeSH descriptors whose meaning is more general than "raf Kinases".
Below are MeSH descriptors whose meaning is more specific than "raf Kinases".
This graph shows the total number of publications written about "raf Kinases" by people in this website by year, and whether "raf Kinases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 2 | 2 |
| 2015 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "raf Kinases" by people in Profiles.
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DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters. Cell Rep. 2019 12 10; 29(11):3448-3459.e6.
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Oncogenesis driven by the Ras/Raf pathway requires the SUMO E2 ligase Ubc9. Proc Natl Acad Sci U S A. 2015 Apr 07; 112(14):E1724-33.
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PAF-mediated MAPK signaling hyperactivation via LAMTOR3 induces pancreatic tumorigenesis. Cell Rep. 2013 Oct 31; 5(2):314-22.
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Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo. Blood. 2013 Jun 13; 121(24):4884-93.
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Inhibition of the Ras/Raf/MEK/ERK and RET kinase pathways with the combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in medullary and differentiated thyroid malignancies. J Clin Endocrinol Metab. 2011 Apr; 96(4):997-1005.
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Calcineurin sets the bandwidth for discrimination of signals during thymocyte development. Nature. 2007 Nov 29; 450(7170):731-5.
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Regulation of mucin gene expression by CREB via a nonclassical retinoic acid signaling pathway. Mol Cell Biol. 2007 Oct; 27(19):6933-47.
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Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma. Cancer Res. 2007 Feb 15; 67(4):1502-12.
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Novel combinations based on epidermal growth factor receptor inhibition. Clin Cancer Res. 2006 Jul 15; 12(14 Pt 2):4446s-4450s.
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Balance between polyoma enhancing activator 3 and activator protein 1 regulates Helicobacter pylori-stimulated matrix metalloproteinase 1 expression. Cancer Res. 2006 May 15; 66(10):5111-20.